基于Profibus总线的薄膜生产线的设计

论文介绍了双向拉伸聚丙烯（BOPP）薄膜的生产方法及工艺流程,并根据控制要求设计了BOPP薄膜生产线控制系统.在上位机设计了基于WinCC的监控界面,便于系统调试和用户设定参数 在下位机以西门子CPU 414为控制器,应用Profibus总线控制其他功能模块（如变频器、ET200M等）,使得系统很好地满足生产线的自动控制要求.     

面向云-端融合的移动互联网应用运行平台

与传统的互联网应用相比,移动互联网应用尽管也运行于Web技术栈之上,但移动设备的便携性和多样性,带来了客户端设备计算能力相对有限、数据存储随需而变、显示屏幕大小不一、本地应用与Web应用和服务难以交互等技术挑战．为此,本文设计实现了一种面向云一端融合的移动互联网应用运行平台．首先,提出一种符合移动互联网应用体系结构的构件模型,将客户端应用划分为数据、计算、界面和服务四个部分;其次,设计了一种实现云一端资源融合的构件运行框架,支持应用数据的按需存储、计算任务的云端迁移、以及用户界面的动态切分;再次,设计了一种实现云一端服务融合的组装框架,支持客户端本地应用和传统Web应用的服务封装、和基于总线的服务即时组装;最后,基于Chrome浏览器实现了平台原型,支持基于HTML5和JavaScript的移动互联网应用,通过多个Web应用基准测试集和热点应用的实验,验证了平台的有效性和可行性．     

网格模型上的离散测地线

测地线是微分几何中的重要概念,用于描述曲面上两点之间的最短曲线,相当于平面上两点之间的直线段,它在计算机图形学、图像处理、计算几何、计算机视觉等学科中有着广泛的应用.自20世纪80年代以来,关于离散测地线已有广泛研究,众多学者提出了许多切实可行的算法.本文将在介绍光滑曲面上的测地线和离散网格上测地线概念的基础上,对网格模型上的离散最短测地线和最直测地线的定义、性质及相关算法进行归纳总结,重点讨论网格模型上离散最短测地线的相关算法,包括完整网格和有缺陷网格上最短测地线的精确算法和逼近算法,对各类算法进行深入研究,详细论述每个算法的基本思想与实现方法,从多个角度分析每个算法的优缺点,并对他们各自的时间复杂度、空间复杂度及适用范围等进行对比,最后对离散测地线的相关研究进行展望,有利于后续对测地线算法的深入研究.     

月地高速再入返回飞行器信息系统设计与实现

探月三期月地高速再入返回飞行器由服务舱和返回器2个舱段组成,信息系统复杂,首先对信息系统的任务进行了分析,在此基础上提出了2层拓扑总线的互联方案、器内多子网自识别路由设计方案、链路层分层方案,脉冲调制编码(PCM)数据体制与高级在轨系统(AOS)数据体制统一设计方案,实现了多信源、多舱段信息管理与融合,提高了上行带宽利用率、器内数据路由和下行遥测灵活性和易扩展性,满足了飞行任务复杂工作模式下的需求,在轨飞行结果表明信息系统满足需求.     

创业投资辛迪加网络中控制权的演化博弈分析

创业投资的高风险性和信息不对称性使创业投资中控制权分配问题逐渐成为关系到风险投资项目成败的关键。本文运用演化博弈方法,分析控制权在辛迪加网络中两类创业投资家之间分配的博弈过程,得出在不同控制权分配比例下相应的演化稳定策略。在此结果上表明即期博弈中,创业投资家的私人收益和项目产出分配值的对比关系与控制权的分配密切相关。     

Exome sequencing of liver fluke-associated cholangiocarcinoma

Opisthorchis viverrini-related cholangiocarcinoma (CCA), a fatal bile duct cancer, is a major public health concern in areas endemic for this parasite. We report here whole-exome sequencing of eight O. viverrini-related tumors and matched normal tissue. We identified and validated 206 somatic mutations in 187 genes using Sanger sequencing and selected 15 genes for mutation prevalence screening in an additional 46 individuals with CCA (cases). In addition to the known cancer-related genes TP53 (mutated in 44.4% of cases), KRAS (16.7%) and SMAD4 (16.7%), we identified somatic mutations in 10 newly implicated genes in 14.8-3.7% of cases. These included inactivating mutations in MLL3 (in 14.8% of cases), ROBO2 (9.3%), RNF43 (9.3%) and PEG3 (5.6%), and activating mutations in the GNAS oncogene (9.3%). These genes have functions that can be broadly grouped into three biological classes: (i) deactivation of histone modifiers, (ii) activation of G protein signaling and (iii) loss of genome stability. This study provides insight into the mutational landscape contributing to O. viverrini-related CCA.     

Common variants at 12q14 and 12q24 are associated with hippocampal volume

Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of <4.0 × 10(-7). In two additional samples (n = 2,318), associations were replicated at 12q14 within MSRB3-WIF1 (discovery and replication; rs17178006; P = 5.3 × 10(-11)) and at 12q24 near HRK-FBXW8 (rs7294919; P = 2.9 × 10(-11)). Remaining associations included one SNP at 2q24 within DPP4 (rs6741949; P = 2.9 × 10(-7)) and nine SNPs at 9p33 within ASTN2 (rs7852872; P = 1.0 × 10(-7)); along with the chromosome 12 associations, these loci were also associated with hippocampal volume (P < 0.05) in a third younger, more heterogeneous sample (n = 7,794). The SNP in ASTN2 also showed suggestive association with decline in cognition in a largely independent sample (n = 1,563). These associations implicate genes related to apoptosis (HRK), development (WIF1), oxidative stress (MSR3B), ubiquitination (FBXW8) and neuronal migration (ASTN2), as well as enzymes targeted by new diabetes medications (DPP4), indicating new genetic influences on hippocampal size and possibly the risk of cognitive decline and dementia.     

Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm

A high-density haplotype map recently enabled a genome-wide association study (GWAS) in a population of indica subspecies of Chinese rice landraces. Here we extend this methodology to a larger and more diverse sample of 950 worldwide rice varieties, including the Oryza sativa indica and Oryza sativa japonica subspecies, to perform an additional GWAS. We identified a total of 32 new loci associated with flowering time and with ten grain-related traits, indicating that the larger sample increased the power to detect trait-associated variants using GWAS. To characterize various alleles and complex genetic variation, we developed an analytical framework for haplotype-based de novo assembly of the low-coverage sequencing data in rice. We identified candidate genes for 18 associated loci through detailed annotation. This study shows that the integrated approach of sequence-based GWAS and functional genome annotation has the potential to match complex traits to their causal polymorphisms in rice.