利用最小二乘法估算Shooman模型中的参数及其程序实现

本文给出Shooman模型中参数的一种有效的估算方法，能使整体性能最优的最小二乘法。并给出其具体的程序实现。     

溴化(对乙氧羰基苯基)亚甲基三苯鉮的制备

本文报道了一种制备砷■ittig试剂的简便方法并已成功的应用于乙烯衍生物和环丙烷衍生物的合成。     

可持续发展与人力资本的再创造

从可持续发展的涵义和人力资本的动态性，我们不难看出，人力资本的再创造和可持续发展之间有看密不可分的关系，人力资本的再创造既是可持续发展的前提，又是可持续发展的保障。为了使经济社会可持续发展，我们必须采取各种有效措施来实现人力资本的再创造。     

从现代竞走技术发展谈我省竞走裁判队伍的建设

随着竞走技术水平的不断发展和提高,竞走比赛愈加紧张激烈,这就增加了裁判员工作的难度.现代竞走运动对裁判员的能力提出了更高的要求,因为运动员在比赛中能否正常发挥附合规则的技术,这和裁判员的工作有直接关系,所以,建设一支高水平的裁判员队伍,是加速我省竞走运动发展的关键所在。     

几种常见回转曲面短程线的几何分析及其计算机绘制

本文在微分几何理论基础上，通过非线性方程求根与数值积发相结合的方法给出了回转抛物面、回转椭球面、单叶回转双曲面、圆环面等常见回转曲面上短程线的计算方法及其计算机绘制。计算机绘制短程线，在工程实际及数学、物理、力学理论中都是很重要的。     

从佛郎国献天马事看蒙古人的尚马情结

意大利罗马教皇委派佛罗伦萨教士马黎诺里向元顺帝妥欢帖睦尔进呈教皇信件和一匹佛郎国（令法国）异马，引起元廷震动，谓之天马。顺帝在朝中举行盛会，令文人学士和画家著诗文、作画来记述这一盛事，《元史》亦有记载。蒙古族作为马背民族，对于马寄有深厚的感情。此时的域外贡马之事，引起朝中蒙古族上层对自己民族往事的回顾与追忆。他们在马身上寄托和传承着美好的理想和追求。同时，也表现出元末中国与其他国家之间接触频繁，其文化交流处在良性循环的状态之中。     

BE—8347—14固定液对水中痕量酚的分离性能的研究

本文用BE—8341—14固定液对松花江水中痕量酚的测定,并对其在气相色谱中的分离性能以模式水样进行了研究。其结果表明,该固定液为实际水样中痕量酚的测定提供了新的参考方法。     

β－环糊精包结中的乙酸苯酯的固相Fries重排反应

研究了β－环糊精包结中的乙酸酯前的固相Ｆｒｉｅｓ重排反应，发现生成邻位产物的选择性很高，产率达１００％．     

Dysregulation of the TSC-mTOR pathway in human disease

The mammalian target of rapamycin (mTOR) has a central role in the regulation of cell growth. mTOR receives input from multiple signaling pathways, including growth factors and nutrients, to stimulate protein synthesis by phosphorylating key translation regulators such as ribosomal S6 kinase and eukaryote initiation factor 4E binding protein 1. High levels of dysregulated mTOR activity are associated with several hamartoma syndromes, including tuberous sclerosis complex, the PTEN-related hamartoma syndromes and Peutz-Jeghers syndrome. These disorders are all caused by mutations in tumor-suppressor genes that negatively regulate mTOR. Here we discuss the emerging evidence for a functional relationship between the mTOR signaling pathway and several genetic diseases, and we present evidence supporting a model in which dysregulation of mTOR may be a common molecular basis, not only for hamartoma syndromes, but also for other cellular hypertrophic disorders.     

Genomic alterations in cultured human embryonic stem cells

Cultured human embryonic stem cell (hESC) lines are an invaluable resource because they provide a uniform and stable genetic system for functional analyses and therapeutic applications. Nevertheless, these dividing cells, like other cells, probably undergo spontaneous mutation at a rate of 10(-9) per nucleotide. Because each mutant has only a few progeny, the overall biological properties of the cell culture are not altered unless a mutation provides a survival or growth advantage. Clonal evolution that leads to emergence of a dominant mutant genotype may potentially affect cellular phenotype as well. We assessed the genomic fidelity of paired early- and late-passage hESC lines in the course of tissue culture. Relative to early-passage lines, eight of nine late-passage hESC lines had one or more genomic alterations commonly observed in human cancers, including aberrations in copy number (45%), mitochondrial DNA sequence (22%) and gene promoter methylation (90%), although the latter was essentially restricted to 2 of 14 promoters examined. The observation that hESC lines maintained in vitro develop genetic and epigenetic alterations implies that periodic monitoring of these lines will be required before they are used in in vivo applications and that some late-passage hESC lines may be unusable for therapeutic purposes.