集聚效应对中国风电产业发展差异影响的实证研究

风电产业的发展是清洁能源发展的热点之一。本文从产业集聚效应的角度出发,深入研究了我国风电产业链的发展情况,利用地区集中度LQ指标对2009~2012年华北、东北、西北和江苏沿海风电产业集聚情况进行了实证研究,得出我国四大区域确实存在风电产业集聚现象。同时利用产业地区集中度cR指标测度各地的市场集中度,深入分析了我国典型地区的风电产业集聚特征,得出受集聚效应和各地经济资源禀赋不同的影响,我国风电产业发展存在差异且缺少地区间的产业联动发展,并提出相应的对策建议。     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation

Canalization, also known as developmental robustness, describes an organism's ability to produce the same phenotype despite genotypic variations and environmental influences. In Drosophila, Hsp90, the trithorax-group proteins and transposon silencing have been previously implicated in canalization. Despite this, the molecular mechanism underlying canalization remains elusive. Here using a Drosophila eye-outgrowth assay sensitized by the dominant Kr(irregular facets-1)(Kr(If-1)) allele, we show that the Piwi-interacting RNA (piRNA) pathway, but not the short interfering RNA or micro RNA pathway, is involved in canalization. Furthermore, we isolated a protein complex composed of Hsp90, Piwi and Hop, the Hsp70/Hsp90 organizing protein homolog, and we demonstrated the function of this complex in canalization. Our data indicate that Hsp90 and Hop regulate the piRNA pathway through Piwi to mediate canalization. Moreover, they point to epigenetic silencing of the expression of existing genetic variants and the suppression of transposon-induced new genetic variation as two major mechanisms underlying piRNA pathway-mediated canalization.     

嵌入式系统上的图形界面输入引擎的研究

嵌入式系统上的图形用户界面（GUI）由于基于不同的软硬件平台,输入设备有很大差别,所以开发者在移植时要为不同的输入设备开发其与GUI之间的接口,以使得GUI能够正确响应用户的输入。GUI的输入引擎就是介于GUI处理核心和操作系统的输入设备驱动程序之间的一组抽象接口,它的功能是使不同的输入设备的驱动程序能够无缝地连接到GUI的消息处理程序中。因此,输入引擎可以改善GUI的可移植性。在基于at91rm9200微处理器和嵌入式Linux操作系统的软硬件平台上．讨论了开发GUI输入引擎的一般方法,并结合一个具体的GUI系统——MiniGUI,给出了一个输入引擎实例的开发过程。     

网络环境下高校图书馆服务工作的探讨

介绍了网络环境下深化图书馆建设的策略,包括提高图书馆员的综合素质与能力和运用现代化技术手段为读者服务。     

Experimental study of heat transfer of ultra-supercritical pressure water in vertical upward internally ribbed tube

Under ultra-supercritical pressure, the heat transfer characteristics of water in vertical upward 4-head internally ribbed tubes with a diameter of 28.65mm and thickness of 8mm were experimentally studied. The experiments were performed at P=25～34MPa, G=450～1800kg/(m2·s) and q=200～600kW/m2. The results show that the pressure has only a moderate effect on the heat transfer of ultra-supercritical water when the water temperature is below the pseudocritical point. Sharp rise of the wall temperature near the pesudocritical region occurs earlier at a higher pressure. Increasing the mass velocity improves the heat transfer with a much stronger effect below the pesudocritical point than that above the pesudocritical point. For given pressure and mass velocity, the inner wall heat flux also shows a significant effect on the inner wall temperature, with a higher inner wall heat flux leading to a higher inner wall temperature. Increasing of inner wall heat flux leads to an early occurrence of sharp rise of the wall temperature. Correlations of heat transfer coefficients are also presented for vertical upward internally ribbed tubes.     

关于牛顿“碑文”翻译的一个争论

诗人蒲柏曾给牛顿拟过一个碑文，后来虽未予采用，但该诗却流传甚广，很多关于牛顿的文章都引用过它。其后，另一个英国诗人J．C．斯奎尔，按同样的形式又续了一首诗。对于后一首诗准确的理解和翻译，曾经引起了一场很热烈的争论。