Fabrication of solenoid-type microinductor with different magnetic core schemes by MEMS technique

0 IntroductionThere has been a great demand on micro DC/DCconverter for the applications of the portable electronicproducts such as mobile communication product CDMA(Code Division Multiple Access) ,portable notebookcom-puter ,microprocessor ,digital camcorder andso on.Mag-netic components such as inductors and transformers arethe essential components in constructingthe power supplytransformer ,filter , oscillator , amplifier and micro DC/DCconverter ,andthe miniaturization of inductor an…     

A buffer insertion and simultaneous sizing timing optimization algorithm

A path-based timing optimization algorithm for buffer insertion and simultaneous sizing is proposed. Firstly, candidate buffer insertion location and buffer size for each branch in a given routing path were obtained via localized timing optimization. Then, through evaluating each potential insertion against design objectives, potential optimal buffer insertion locations and sizes for the whole routing tree were determined. At last, by removing redundant buffer insertion operations which do not maximize S （ so ）, given timing requirements are finally fulfilled through minimum number of buffers.     

定西市地下水开采引起的环境地质问题及对策

定西市城市供水主要依赖于西部的内官-香泉盆地地下水。本文从定西市城市供水水源地水文地质特征和地下水动态分析入手,指出由于长期的超量开采导致地下水位急剧下降,定西市城市供水水源地已面临地下水资源枯竭等环境地质问题。如何有效的利用地下水资源,以满足定西市城市经济的可持续发展已成为十分紧迫问题。除了采取节水措施,提高水资源的利用率外,跨流域调水是中远期解决定西城市供水的有效对策。     

Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus

Coats plus is a highly pleiotropic disorder particularly affecting the eye, brain, bone and gastrointestinal tract. Here, we show that Coats plus results from mutations in CTC1, encoding conserved telomere maintenance component 1, a member of the mammalian homolog of the yeast heterotrimeric CST telomeric capping complex. Consistent with the observation of shortened telomeres in an Arabidopsis CTC1 mutant and the phenotypic overlap of Coats plus with the telomeric maintenance disorders comprising dyskeratosis congenita, we observed shortened telomeres in three individuals with Coats plus and an increase in spontaneous γH2AX-positive cells in cell lines derived from two affected individuals. CTC1 is also a subunit of the α-accessory factor (AAF) complex, stimulating the activity of DNA polymerase-α primase, the only enzyme known to initiate DNA replication in eukaryotic cells. Thus, CTC1 may have a function in DNA metabolism that is necessary for but not specific to telomeric integrity.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation

Canalization, also known as developmental robustness, describes an organism's ability to produce the same phenotype despite genotypic variations and environmental influences. In Drosophila, Hsp90, the trithorax-group proteins and transposon silencing have been previously implicated in canalization. Despite this, the molecular mechanism underlying canalization remains elusive. Here using a Drosophila eye-outgrowth assay sensitized by the dominant Kr(irregular facets-1)(Kr(If-1)) allele, we show that the Piwi-interacting RNA (piRNA) pathway, but not the short interfering RNA or micro RNA pathway, is involved in canalization. Furthermore, we isolated a protein complex composed of Hsp90, Piwi and Hop, the Hsp70/Hsp90 organizing protein homolog, and we demonstrated the function of this complex in canalization. Our data indicate that Hsp90 and Hop regulate the piRNA pathway through Piwi to mediate canalization. Moreover, they point to epigenetic silencing of the expression of existing genetic variants and the suppression of transposon-induced new genetic variation as two major mechanisms underlying piRNA pathway-mediated canalization.     

集聚效应对中国风电产业发展差异影响的实证研究

风电产业的发展是清洁能源发展的热点之一。本文从产业集聚效应的角度出发,深入研究了我国风电产业链的发展情况,利用地区集中度LQ指标对2009~2012年华北、东北、西北和江苏沿海风电产业集聚情况进行了实证研究,得出我国四大区域确实存在风电产业集聚现象。同时利用产业地区集中度cR指标测度各地的市场集中度,深入分析了我国典型地区的风电产业集聚特征,得出受集聚效应和各地经济资源禀赋不同的影响,我国风电产业发展存在差异且缺少地区间的产业联动发展,并提出相应的对策建议。