Application of EEG multipole model in the diagnosis of Alzheimer''''s disease

In order to find the electroencephalogram （EEG） characteristic parameters typical of Alzheimer＇s disease （AD） and explore an effective diagnostic method, a new mobile current multipole model was proposed to simulate the AD patient＇s cortical dipole source activities. The indicators of goodness of fit （GOF） and DtononD （DD） were calculated from EEG samples to evaluate the performance of this model. Relevant results showed that this multipole model with higher GOFvalues and larger DD change well fitted the pathological electrical activities of cortical neurons aroused by AD＇s extended sulcus and gyrus in the cerebral cortex. Meanwhile, the products of DD mean ＆ standard variance were found in a clear linear correlation with the diagnostic data of mini-mental state examination （MMSE） used in AD clinics. Furthermore, by tracing this multipole model＇s indicators in typical patients and contrasting with the functional magnetic resonance image （fMRI） as AD progressed, we suggested that the DD index may be suitable for monitoring the AD developments as a new diagnostic parameter.     

中国城市公交网络冗余度分析

可靠和强韧的城市公交网络不仅关系到城市居民的出行便捷性,同时也对维持整个城市系统的正常运转起着关键性作用．复杂系统的可靠性和强韧性的一个重要指标就是冗余度,即同一功能组件在一个系统中的重复备份．然而,对于城市公交网络的冗余程度的认识依然比较模糊．文章基于复杂网络的连通性理论和遗传优化算法,利用两种公交网络的冗余度的度量指标,即全局冗余度和局域冗余度,对8个具有城市化梯度的中国城市公交网络进行全面的冗余度分析．结果显示,公交网络的全局冗余度明显高于局域冗余度,同时城市中的局域冗余连通块呈现明显的异质分布特征．研究结果对于未来公交线路优化和设计具有一定的参考价值．     

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

Epigenetic silencing in cancer cells is mediated by at least two distinct histone modifications, polycomb-based histone H3 lysine 27 trimethylation (H3K27triM) and H3K9 dimethylation. The relationship between DNA hypermethylation and these histone modifications is not completely understood. Using chromatin immunoprecipitation microarrays (ChIP-chip) in prostate cancer cells compared to normal prostate, we found that up to 5% of promoters (16% CpG islands and 84% non-CpG islands) were enriched with H3K27triM. These genes were silenced specifically in prostate cancer, and those CpG islands affected showed low levels of DNA methylation. Downregulation of the EZH2 histone methyltransferase restored expression of the H3K27triM target genes alone or in synergy with histone deacetylase inhibition, without affecting promoter DNA methylation, and with no effect on the expression of genes silenced by DNA hypermethylation. These data establish EZH2-mediated H3K27triM as a mechanism of tumor-suppressor gene silencing in cancer that is potentially independent of promoter DNA methylation.     

晶体电子的特性探讨

在量子理论的基础上，对周期场中运动的电子的特性进行了探讨，并将晶体电子与索末菲自由电子的特性进行了详细比较。     

社会主义市场经济理论与教学实践

社会主义市场经济理论要成为大学生在今后社会实践中的思想武器,需在预科教学实践中结合社会经济现实,针对预科生的实际,联系他们感兴趣的社会经济问题,如高校扩招、收益分配等,以加深他们对社会主义市场经济理论的理解,从而达到学以致用的目的。     

小型英文软件的汉字化

本文阐述了小型英文软件由个人汉字化的捷径与方法,特别指出了汉字DE BUG在英文软件汉字化的作用。     

均质、非均质地层伤害评价通式和现代试井分析模式

地层伤害有许多描述方法,但其数学关系不明确,没有统一标准。其基本评价方法是不稳定试井,对普通油层Horner和由线拟合法很方便,但对复杂均质油层尤其非均质油层,前法很少凑效,后者唯一性较差。本文提出表皮系数同其它各种地层伤害参数间的关系通式和统一标准;系统介绍了均质、非均质油层求地层伤害的现代试井程序,包括分析基础、目的、关键和可靠性等人工智能的初步模式。     

高韧性易燃特厚煤层巷道自燃监测预报技术

针对磁窑堡二矿自然发火期短且为高韧性特厚易自燃煤层,且综放面回风顺槽与多个旧巷贯通或相邻,使得巷道掘进及回采期间自燃危险性增大的特点,对巷道掘进期间实施了有效的防灭火措施方案,保障综放面安全顺利开采。     

大学毕业生频繁跳槽的成因及其治理

大学毕业生频繁跳槽,其背后有着深层次的政治、经济、文化和社会等多方面的原因。社会各界必须对这一现象引起足够重视,综合治理好大学毕业生跳槽问题。重建高校诚信声誉,端正大学生择业观念,加强大学生思想素质教育,提高大学生的就业心理承受能力,帮助大学生进行职业生涯规划,进一步规范大学生的就业市场,完善用人单位的用人机制以及加快社会法制建设等都是解决大学毕业生频繁跳槽问题的有效措施。     

形如1/2(a2n+1)的孤立数

设a是正整数,13≤a≤31,证明了1/2(a2n+1)(2(|)a)都是孤立数,这里n是任意的正整数.