微分干涉相衬层析显微镜的相干传递函数

通过系统在低相干光源照明情况下对生物组织成像机理的分析,探讨了系统具有很强纵深分辨能力的原因,在此基础上,利用信息光学的理论和方法研究了图像的形成和传递过程,推导了系统的相干传递函数．结果表明系统的横向成像具有低通特性,纵向成像具有带通特性．本研究工作为全视场层析探测提供了理论依据．     

基于WebGIS 的汉江水环境管理信息系统

依据互联网地理信息系统（WebGIS）的实现技术及特点,分析了ArcIMS的体系结构及其运行机制,通过基于ArcIMS9平台并结合JS,JSP等技术,提出一种新的具有多层结构的WebGIS解决方案,并结合具体实例阐述了其在水环境管理信息系统的实现．结合水环境管理信息系统的需求,给出了基于WebGIS的水环境管理信息系统的功能体系结构．采用Apache＋Tomcat作为网络服务器、ArcIMS作为地图服务器完成了系统功能设计,实现了网上数字地图的处理、传送,以及基于地图的水环境信息查询、评估、统计、分析,和排放污染总量与污染源的控制决策．     

基于无线个域网的新型语音通信系统

分析了基于W PAN的语音通信系统(VoW PAN)的优点,设计并研制了应用在石油井场的VoW PAN系统.该系统包括音频网关和语音终端2部分,能够提供音频网关到语音终端之间点到点、点到多点的无线语音通信.通过采用高密度封装的蓝牙模块和集成化的设计,减小了系统的尺寸.针对语音终端待机时间短的问题,采用休眠模式、减小扫描窗长度、增大扫描间隔、关闭主机接口等措施,降低了功耗.通过分离音频网关的主机和射频前端,简化了天线的设计难度,降低了成本,克服了某些场合的屏蔽效应.采用规范的蓝牙通信协议,可以与普通的蓝牙产品兼容.经测试,系统的通信距离可达100m.该系统已成功应用于国内许多油田的井场控制.     

二乙二醇甲醚浓度对飞机油箱抗静电涂层的影响

将飞机油箱专用抗静电涂层与不同质量分数二乙二醇甲醚溶液进行浸泡,分析检验涂层在浸泡后的颜色、铅笔硬度、附着力、冲击强度、柔韧性和表面电阻等关键指标的变化情况,用红外光谱、扫描电镜和能谱仪分别检测涂层分子结构、表面形态和元素组成的变化.实验表明:随着二乙二醇甲醚质量分数的不断增加,涂层的力学性能和导静电性能都有不同程度下...     

复杂仿真系统重用模型可信度评估方法

在资源高度共享的今天,模型重用可增强仿真应用的灵活性和可扩展性,是复杂仿真系统构建的必然选择。然而,评估多模型组合仿真下的可信性是模型能否实现有效重用的基本问题。针对面向实物和面向数值解算两个不同应用环境的仿真模型重用,提出基于偏差传播的仿真重用模型可信度评估方法,详细介绍了各自建模方式及评估方法。以无人机复杂仿真系统为例,通过与经典可信度评估方法对比,说明了该方法可降低在重用模型可信度方面的评估难度,验证了方法的可行性。     

De Casteljau Algorithm and Degree Elevation of Toric Surface Patches

De Casteljau algorithm and degree elevation of Bézier and NURBS curves/surfaces are two important techniques in computer aided geometric design. This paper presents the de Casteljau algorithm and degree elevation of toric surface patches, which include tensor product and triangular rational Bézier surfaces as special cases. Some representative examples of toric surface patches with common shapes are illustrated to verify these two algorithms. Moreover, the authors also apply the degree elevation of toric surface patches to isogeometric analysis. And two more examples show the effectiveness of proposed method.     

某大跨度变截面连续箱梁桥时程分析

基于通用有限元程序软件对某桥进行了时程分析,并把理论分析计算结果与实测值进行比较分析,分析结果有助于了解该桥的结构受力性能。     

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.