Overexpression of N-cadherin is correlated with metastasis and worse survival in colorectal cancer patients

N-cadherin is related to the progression and metastases of several solid carcinomas. However, it was still unclear whether N-cadherin is overexpressed in colorectal malignant tumors that have stronger malignant tendency. In this study, we used immunohistochemistry to detect the expression patterns of N-cadherin in both the primary tumors and their normal mucosa tissues of 120 patients with colorectal cancer. We revealed that N-cadherin was expressed in 78.3% (94/120) of colorectal tumor tissues and in only 9.2% (11/120) of paired distant normal mucosa tissues with a significant difference (P=0.000). The low, moderate, and high expression of N-cadherin protein was 42.5%, 30.8%, and 26.7%, respectively. N-cadherin overexpression was associated with advanced TNM stage, lymph nodes metastasis and distant metastasis (P<0.05). Patients with N-cadherin overexpressed showed the obvious lower overall survival rate than those with moderate and low expression, and patients with low expression had a better survival rate than those with moderate and high expression (P<0.05). In conclusion, high N-cadherin expression may lead to tumor aggressiveness and metastatic potential in colorectal cancer, and may prove to be a possible prognostic factor.     

基于代理重加密的云数据共享机制的研究与实现

为了使得云端数据能灵活安全地进行共享,该文对基于代理重加密的共享机制进行了研究。该文利用代理重加密实现代理授权,设计了一种云端数据授权共享方案。代理重加密算法使用了双线性对,其安全性基于判定双线性Diffie-Hellman(Decisional bilinear Diffie-Hellman,DBDH)假设。在该方案基础上,实现了一个基于Hadoop云存储平台的云端数据共享原型系统,对其进行了测试和分析。该系统的数据共享具有高效性和安全性。该文工作对代理重加密在云端数据共享中的应用具有借鉴价值。     

脂质体转移因子的制备及其活性研究

以转移因子为包裹对象,探讨提高脂质体肽类药物的包封率和减缓渗漏率的方法和条件,以及制备过程对活性的影响。采用逆相蒸发法制备、以正交试验设计筛选最佳配方组合,制备负电荷脂质体转移因子。通过巨噬细胞吞噬试验和E-玫瑰花结试验比较不同剂型、不同给药途径对小鼠免疫功能的影响。结果表明：负电荷脂质体转移因子包封率和稳定性均比其他文献报道的有较大的提高,包封率5次平均达43%,30d渗漏率12%,具有一定的稳定性;E-玫瑰花结试验显示：制备过程对转移因子活性无显著影响;巨噬细胞吞噬试验表明：不论注射或口服脂质体转移因子,均有提高机体免疫功能的作用,脂质体转移因子的药效优于游离转移因子。     

具有三个公共值的亚纯函数的唯一性

本文研究了具有三个公共值的亚纯函数的唯一性问题，改进了Ueda,仪洪勋和本文作者的有关定理 。     

一种频域RS-LT级联码在短波通信中的应用研究

针对短波通信中同时存在误码和丢包的特点,提出了一种频域RS码与数字喷泉码串行级联的纠错纠删编码算法,并在FPGA芯片及短波电台终端上予以实现。频域RS码作为外码,LT码作为内码,使RS码和LT码互相促进,同时实现纠删和纠错,这是单独采用两种编码方法都无法达到的。仿真表明RS-LT级联编码可提高LT码译码成功概率。同时短波信道实测结果表明,编码模块的应用可有效提高短波电台正确接收概率。     

基于分层马尔可夫决策过程的AUV全局路径规划研究

自主路径规划是自治式水下机器人(AUV)自主能力的重要体现,是保障AUV在大范围复杂海洋环境中自主完成使命作业的关键技术之一。提出了基于马尔可夫决策过程的路径规划方法;并建立了基本的马尔可夫决策模型和结合状态聚类的分层马尔可夫决策模型,同时给出了两种规划的仿真实验及结果分析。实验证明,此类方法能够很好地求解大范围复杂环境内AUV的二维路径规划问题。     

登陆舰装载输送过程视景仿真系统的研究

基于仿真的船舶设计方法可以离线模拟船舶作业流程,对改进船舶设计方案具有重要的指导意义.然而作业流程的复杂性和实体的多样性增加了仿真模拟的难度.在分析和描述登陆舰装载输送过程的基础上,设计了由物理仿真层、动作指令层和剧本描述层组成的面向复杂仿真过程的系统结构框架:解决了实体物理行为的关键算法、仿真实体类的设计和特效的模块化设计等系统关键技术,利用Creator,Vega和VC 开发工具实现了某型登陆舰装载输送过程视景仿真系统,取得了较好的模拟效果,为设计人员评价舰船设计方案和研究输转方法提供了决策手段和分析工具.     

Adaptive SPC monitoring scheme for DOE-based APC

Automatic process control （APC） based on design of experiment （DOE） is a cost-efficient approach for variation reduction. The process changes both in mean and variance owing to online parameter adjustment make it hard to apply traditional SPC charts in such DOE-based APC applied process. An adaptive SPC scheme is developed, which can better track the process transitions and achieve the possible SPC run cost reduction when the process is stable. The control law of SPC parameters is designed by fully utilizing the estimation properties of the process model instead of traditionally using the data collected from the production line. An example is provided to illustrate the proposed adaptive SPC design approach.     

基于活动轮廓模型的人脸特征提取方法的研究

根据活动轮廓模型理论 ,提出了提取人脸面部特征的系列算法 ,特征是精确的轮廓描述而非简单的数字表达.