De Casteljau Algorithm and Degree Elevation of Toric Surface Patches

De Casteljau algorithm and degree elevation of Bézier and NURBS curves/surfaces are two important techniques in computer aided geometric design. This paper presents the de Casteljau algorithm and degree elevation of toric surface patches, which include tensor product and triangular rational Bézier surfaces as special cases. Some representative examples of toric surface patches with common shapes are illustrated to verify these two algorithms. Moreover, the authors also apply the degree elevation of toric surface patches to isogeometric analysis. And two more examples show the effectiveness of proposed method.     

基于X语言的起飞场景民机协同设计与仿真一体化方法

针对大型复杂产品,传统基于模型的系统工程(model-based system engineering, MBSE)方法存在系统设计和仿真验证的多语言、多平台集成实现,难以保证高效、准确地反馈系统设计的缺陷,无法达到快速优化设计目的等问题,提出采用基于面向复杂系统支持MBSE的新一代一体化建模仿真语言—X语言实现面向起飞场景的民机跨域子系统的一体化建模仿真。从民机起飞过程需求分析出发,建立了起飞场景的系统级模型和物理级模型,并在X语言的建模仿真软件—XLab进行统一的建模仿真验证,给出了基于X语言面向复杂产品协同设计与仿真一体化方法,为不同领域的设计人员实现复杂产品设计的协同与优化提供了全新的理论与方法参考。     

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

欧美关于数字图书馆的纷争与启示

近年来欧美国家关于数字图书馆的一系列纷争,从一贯的知识产权焦点深化至本国文化地位等多层视角,给中国的数字图书馆建设带来诸多启示与借鉴。     

合成生物学与人工生命体

计算机出问题不能工作了,通常我们会选择重装操作系统,而类似的想法在活的细胞中也能够实现.这是怎么回事呢?2007年10月6日,基因组研究先锋美国克雷格·文特尔研究所(J.Craig Venter Institute)已成功地合成了生殖支原体(Mycoplasma genitalium)的基因组.     

从霸权文化看我国文化产业发展所面临的机遇与挑战

今天的西方霸权主义者,正在试图用他们的文化政策去侵略其他国家.他们企图用这种方式控制别国人民的思想和行为,这样的国际形势使我国的文化产业面临相应的机遇与挑战,我们应当抓住机遇,发挥我国的优势,大力的发展自己的文化产业,使我国的文化产业得到长足的进步.     

Proteome changes in the plasma of Papilio xuthus (Lepidoptera: Papilionidae): effect of parasitization by the endoparasitic wasp Pteromalus puparum (Hymenoptera: Pteromalidae)

Although the biochemical dissection of parasitoid-host interactions is becoming well characterized, the molecular knowledge concerning them is minimal. In order to understand the molecular bases of the host immune response to parasitoid attack, we explored the response of Papilio xuthus parasitized by the endoparasitic wasp Pteromalus puparum using proteomic approach. By examining the differential expression of plasma proteins in the parasitized and unparasitized host pupae by two-dimensional (2D) electrophoresis, 16 proteins were found to vary in relation to parasitization compared with unparasitized control samples. All of them were submitted to identification by mass spectrometry coupled with a database search. The modulated proteins were found to fall into the following functional groups: humoral or cellular immunity, detoxification, energy metabolism, and others. This study contributes insights into the molecular mechanism of the relationships between parasitoids and their host insects.     

关于中学图书馆开设阅读课的思考

文章指出图书馆开设阅读课应结合本校的实际情况，有选择地学习、利用各地的先进经验，因地制宜、创造性地构建适合自己学校的图书馆阅读课的形式。