职前小学科学教师的专业发展

职前小学科学教师专业发展是教师终身专业发展的基础阶段。为了促进职前小学科学教师专业发展,提出改革与职前小学科学教师专业发展不适应的课程设置,培养职前小学科学教师自主专业发展意识,加强教育实践和教育研究,从而加速职前小学科学教师的成长和发展。     

浅谈变电站自动化系统调试

文章从变电站现场调试工作前的准备到设备投运的整个工作程序和调试方法及注意事项进行了详细介绍,并说明了细节问题应注意的事项。     

电梯安全钳检验及常见故障问题分析

文章在论述安全钳装置原理的基础上,探讨安全钳的检验检测重点,并就安全钳常见故障问题进行了分析,提出解决措施,最后结合实例,具体分析某电梯安全钳误动作故障及解决办法.     

GPON技术在网络中的应用

文章详细描述了GPON技术的组成、特点、应用模式及组网方案,并通过工程案例介绍了GPON在接入网中的应用。     

浅谈协同商务对会计信息化的影响

协同商务对会计信息化提出了新的挑战。文章探讨了协同商务的含义,并在此基础上归纳了协同商务对会计信息化的影响。     

Programming the magnitude and persistence of antibody responses with innate immunity

Many successful vaccines induce persistent antibody responses that can last a lifetime. The mechanisms by which they do so remain unclear, but emerging evidence indicates that they activate dendritic cells via Toll-like receptors (TLRs). For example, the yellow fever vaccine YF-17D, one of the most successful empiric vaccines ever developed, activates dendritic cells via multiple TLRs to stimulate proinflammatory cytokines. Triggering specific combinations of TLRs in dendritic cells can induce synergistic production of cytokines, which results in enhanced T-cell responses, but its impact on antibody responses remain unknown. Learning the critical parameters of innate immunity that program such antibody responses remains a major challenge in vaccinology. Here we demonstrate that immunization of mice with synthetic nanoparticles containing antigens plus ligands that signal through TLR4 and TLR7 induces synergistic increases in antigen-specific, neutralizing antibodies compared to immunization with nanoparticles containing antigens plus a single TLR ligand. Consistent with this there was enhanced persistence of germinal centres and of plasma-cell responses, which persisted in the lymph nodes for >1.5 years. Surprisingly, there was no enhancement of the early short-lived plasma-cell response relative to that observed with single TLR ligands. Molecular profiling of activated B cells, isolated 7 days after immunization, indicated that there was early programming towards B-cell memory. Antibody responses were dependent on direct triggering of both TLRs on B cells and dendritic cells, as well as on T-cell help. Immunization protected completely against lethal avian and swine influenza virus strains in mice, and induced robust immunity against pandemic H1N1 influenza in rhesus macaques.     

一种新的PDP低灰度级图像增强技术

针对常规PDP显示中的低灰度级轮廓问题,提出了一种新的PDP低灰度级图像增强算法．该算法根据PDP线性离散化的显示特点利用图像的表现率动态选择多种子场的编码,减少了图像伽马变化过程中灰度级的细节损失．针对PDP实际输出亮度相对于输入灰度级有反转的现象进行了理论分析和算法处理,消除了低灰度图像灰阶反转的现象．利用误差扩散算法最大限度地重现了图像的细节．实际结果表明该算法能够减少低灰度级轮廓,其显示效果明显优于传统方案．     

用siRNA抑制胃癌细胞AGS中COX-2表达及对AKT磷酸化的抑制

构建了可在真核细胞中表达针对COX-2基因的siRNA表达载体,并用胃腺癌细胞系AGS建立了COX-2 siRNA的稳定转染细胞系。用Western-Blot检测稳定转染细胞系中COX-2的表达以及AKT的磷酸化水平。结果表明稳定转染C0X-2 siRNA的细胞中COX-2的表达较转染空载体的细胞明显降低,且发现COX-2表达的降低可抑制AKT—Ser^473和Thr-^308的磷酸化水平。为进-步探索抑制COX-2对胃癌细胞生物学特性的影响,及其在肿瘤治疗中的作用奠定了基础。     

大型多媒体中央控制系统的原理及应用

多媒体中央控制系统以其强大的信号整合处理功能与对多媒体设备的集中控制管理功能为优势在生产调度中心、军事指挥中心得了广泛应用。本文以多媒体中央控制系统在军事作战指挥中心的实际工程应用为背景,详细描述了多媒体中央控制系统的工作原理以及其在实际工程中的应用。     

大跨度钢桁梁桥纵向附加力分析与研究

文章以桥上无缝线路梁轨相互作用原理为基础,建立以轨道、桥梁、支座、墩台和基础为整体结构的附加纵向力计算有限元模型,依据"对号入座"法则编制了计算钢桁梁桥上无缝线路的程序。讨论了伸缩调节器设置与否以及设置位置的不同对纵向附加力的影响。