异烟肼-柚皮素共晶的表征及其性能研究

以抗结核药异烟肼和黄酮类天然产物柚皮素为原料,采用混悬法制得异烟肼-柚皮素的药物-药物共晶。通过XRPD、DSC、FTIR、SSNMR和LNMR等分析技术对共晶产物进行了表征,分析了共晶分子间的氢键作用,确定了共晶中异烟肼和柚皮素的比例;对异烟肼、柚皮素和共晶在模拟生理液中的表观平衡溶解度进行了比较研究。结果表明,异烟肼的酰肼基和吡啶氮与柚皮素上的3个羟基在共晶中形成了新的氢键,共晶产物中异烟肼与柚皮素的摩尔比为1∶1;共晶能大幅降低异烟肼的表观平衡溶解度,提高柚皮素的表观平衡溶解度,说明所得共晶能够在保留异烟肼抗结核药效的同时,减弱肝损伤,药理作用明显。     

一种基于微蜂窝小区用户比例公平的改进资源分配算法

在微蜂窝小区用户速率比例公平约束条件下,以最大化系统和速率为目标,提出了一种改进资源分配算法,并用拉格朗日法求解优化功率.结果表明:相比于传统的最低比例速率的资源分配算法,本算法在频率和总功率固定的条件下,能减少计算复杂度,且系统速率提高了约2%.     

既有大跨空间钢结构安全性评定方法

从构件角度对既有大跨度空间钢结构的安全性评定方法进行研究,根据<建筑结构可靠度设计统一标准>(GB 50068-2001)规定的结构构件承载能力极限状态的可靠度指标,提出既有钢结构构件的安全性等级应划分为安全与不安全两等级.基于荷载模型和抗力模型,确定了作用于既有大跨空间钢结构的各类荷载标准值.以分项系数确定的抗力与可靠度指标确定的抗力相对误差最小为原则编写可靠度程序,得到适合既有大跨空间钢结构评定的γG=1.2,γQ=1.3,以及各类构件的最优抗力分项系数.在综合考虑构件权重的基础上,提出了以整体性、承载安全性和整体稳定性的最低等级作为结构安全性等级的安全性评定方法.     

SHRIMP U-Pb zircon age of tuff at the bottom of the Lower Cambrian Niutitang Formation,Zunyi, South China

A SHRIMP U-Pb zircon geochronology study of the tuff at the bottom of the Lower Cambrian Niutitang Formation at Songlin, Zunyi, South China yielded a mean ^206Pb/^238U age of 518±5 Ma. It is significantly younger than the Re-Os ages of 537--542 Ma for the overlying polymetallic Ni-Mo-PGE-rich layer in the basal Niutitang Formation at Songlin, suggesting that the Re-Os ages might represent that of the original magma chamber for the Ni-Mo-PGE-rich layer rather than the formation age of the strata. The intra-basinal stratigraphic correlation also implies that the absolute age of the Chengjiang biota should be younger than 518±5 Ma. Our new result, together with the SHRIMP U-Pb zircon age for the K-bentonite in the Zhongyicun member of the Zhujiaqing Formation at the Meishucun section, Yunnan Province, provides a temporal constraint for the Lower Cambrian of the Yangtze Platform in South China.     

Transmission of oxygen isotope signals of precipitation-soil water-drip water and its implications in Liangfeng Cave of Guizhou,China

According to systemically monitoring results of oxygen （hydrogen） isotope compositions of precipitation, soil waters, soil CO2, cave drip waters and their corresponding speleothems in Liangfeng Cave （LFC） in Guizhou Province, Southwest China, it is found that local precipitation is the main source of soil waters and drip waters, and that the amplitudes of those δ18O values of three waters （precipitation, soil water and drip water） decrease in turn in the observed year, which are 0‰ to -10‰, -2‰ to -9‰ and -6‰ to -8‰, respectively. Moreover, the δ18O values for three waters show a roughly simultaneous variation, namely, that those values are lighter in the rainy seasons, weightier in the dry seasons, and that the average δ18O value of drip waters is about 0.3‰ weightier than that of precipitation, which is modified by surface evaporation processes. We also find that oxygen isotope equilibrium is reached or neared in the formation processes of speleothems in LFC system, and that it is feasible to reconstruct paleotemperature and paleoprecipitation by using δ18O values of speleothems. However, it should be noted that surface evaporation would affect the oxygen isotope values in the study area.     

Biosynthesis of selenosubtilisin: A novel way to target selenium into the active site of subtilisin

Glutathione peroxidase （GPx, EC1.11.1.9）, an important anti-oxidative selenoenzyme, can catalyze the reduction of harmful hydroperoxides with concomitant glutathione, thereby protecting cells and other biological issues against oxidative damage. It captures considerable interest in redesign of its function for either the mechanism study or the pharmacological development as an antioxidant. In order to develop a general strategy for specifically targeting and operating selenium in active sites of enzymes, the catalytically essential residue selenocysteine （Sec） was first successfully bioincorporated into the catalytic center of subtilisin by using an auxotrophic expression system. The studies of the catalytic activity and the steady-state kinetics demonstrated that selenosubtilisin is an excellent GPx-like biocatalyst. In comparison with the chemically modified method, biosynthesis exhibits obvious advantages： Sec could be site-directly incorporated into active sites of enzymes to overcome the non-specificity generated by chemical modification. This study provides an important strategy for specifically targeting and operating selenium in the active site of an enzyme.     

文化语境在语言交际中的应用

文章从文化习俗和社会规范两个方面研究了文化语境在语言交际中的应用.     

矩形钢管混凝土大跨度带悬挑桁架的试验研究

矩形钢管混凝土桁架能充分发挥钢管混凝土的受力性能,是适用于大跨度结构的结构形式。本文通过对2个大尺寸的大跨带悬挑矩形钢管混凝土桁架和矩形钢管桁架模型对比试验,考察了该桁架结构的破坏形态、变形特点和承载性能。试验结果表明,填充混凝土的钢管混凝土桁架试件的刚度提高、变形减小,极限承载力也有所提高,填充混凝土可以有效防止受压钢管壁的局部屈曲,试件破坏受材料的强度控制;采用直接焊接节点连接的钢管桁架和钢管混凝土桁架中腹杆和弦杆在节点处的杆端弯距较大,其对节点承载力的影响不可忽略,在设计中应加以考虑。     

ZnCr_2O_4陶瓷湿度检测新方法应用研究

根据ZnCr2 O4陶瓷的吸湿动力学方程G =Ka×P(H2 O)×t和脱湿动力学方程ln(G) =-Kd×t×exp(Ea/RT)制备一种湿度检测器 ,这种检测器克服了以往应用电阻型湿敏陶瓷来检测湿度时存在的诸多局限 ,确定了湿敏陶瓷在大范围温区湿度的定量检测 ,用这种检测器来考察土壤的吸、脱水功能 ,能较为简便地识别该土壤的保水抗旱能力 ,确定其是否适合于农作物的生长 .制备的这种湿度检测器还为解决粮食的防湿保质问题提供了一条切实可行的途径 .