Apolipoprotein CIII hyperactivates β cell CaV1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src

Apolipoprotein CIII (ApoCIII) not only serves as an inhibitor of triglyceride hydrolysis but also participates in diabetes-related pathological events such as hyperactivation of voltage-gated Ca²⁺ (Ca_V) channels in the pancreatic β cell. However, nothing is known about the molecular mechanisms whereby ApoCIII hyperactivates β cell Ca_V channels. We now demonstrate that ApoCIII increased Ca_V1 channel open probability and density. ApoCIII enhanced whole-cell Ca²⁺ currents and the Ca_V1 channel blocker nimodipine completely abrogated this enhancement. The effect of ApoCIII was not influenced by individual inhibition of PKA, PKC, or Src. However, combined inhibition of PKA, PKC, and Src counteracted the effect of ApoCIII, similar results obtained by coinhibition of PKA and Src. Moreover, knockdown of β1 integrin or scavenger receptor class B type I (SR-BI) prevented ApoCIII from hyperactivating β cell Ca_V channels. These data reveal that ApoCIII hyperactivates β cell Ca_V1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src.     

试析如何深化发展高校图书馆学科馆员服务

随着现代科学技术的迅猛发展及数字信息资源的迅速增长,学科馆员服务也需要进一步深化。从服务理念、服务模式、服务内容3方面描述了学科馆员服务的正确定位,并对深化发展高校图书馆学科馆员服务提出了几点对策。     

基于系统动力学的生鲜农产品国际冷链物流运作风险控制研究——以云南省生鲜蔬菜国际冷链物流为例

以云南省生鲜蔬菜国际冷链物流为例,从系统的角度对国际冷链物流运作风险进行分析,找出主要风险因素,明确风险系统的内部结构及反馈机制,构建生鲜农产品国际冷链物流运作风险的系统动力学模型.模拟仿真结果显示:国际冷链物流运作前6天成本风险和时间风险较高.10天后品质风险较高;风险控制策略具有一定的滞后性,通常在2天以后才生效;当风险控制策略实施有效且风险控制成本占物流运作费用的比例在15％左右时,国际冷链物流运作绩效最高.降低风险的对策措施是:企业间加强协调合作,注重果蔬预冷环节;提前进行合理的风险评估,做好风险防治;综合考虑风险控制成本、运作风险、运作绩效三方面的均衡.     

吉林省新材料产业的发展思考

世界各国越来越重视以科技为导向的新兴技术产业的发展。而在新兴产业中,新材料产业占有非常重要的地位。本文以SWOT分析的形式对吉林省新材料产业的发展现状进行梳理,并提出相关建议。希望本文的研究对加快吉林省新材料产业的发展产生一定的现实借鉴意义。     

Glutenin macropolymer particles size distribution of six wheat varieties in eastern China

Size distribution of glutenin macropolymer(GMP) particles significantly affects the quality of final products in wheat. Six wheat varieties in eastern China were used for investigating the GMP content, particle size distribution and their relation. The results showed that the particle diameter of GMP changed from 0.38 μm to 269 μm. A typical bimodal curve of volume distribution of particles with peak values ranged from 4.44 μm to 5.36 μm and from 45.76 μm to 116.30 μm, respectively. Number distribution of particles showed the typical population with peak values in the range of 0.57-1.00 μm. Proportions of granules 12 μm, 12-80 μm and 80 μm were in the range of 17.1%-47.8%, 32.1%-50.3% and 10.2%-38.1% of total volume, respectively. The content of GMP was negatively correlated with the volume of GMP particles 12 μm, but positively correlated with the volume of particles 80 μm. The results suggested that the greater percentage of larger GMP particles is, the more GMP content there is in wheat grain.     

藏族风格二胡作品演奏相关的技术和风格分析——以内地作曲家创作的四部二胡独奏曲为例

文章对藏族风格二胡独奏曲《金珠玛米赞》、《洁白的哈达》、《北京有个金太阳》和《洁白的哈达》四部作品的创作背景、风格特色、曲式结构、演奏技法等进行了分析,提出对与作品演奏相关的音乐意象、表情、情绪控制等的准确把握也是演奏成功的重要因素.     

基于基因算法的用于系统识别的测试信号的设计

详细介绍了如何用Matlab实现基因算法生成两个不同的具有最小峰值的测试信号,并且把这两个不同的测试信号输入到一个识别工具箱里,通过检验输出的结果来确定这两个测试信号是否适合用作特殊系统的识别.本文所用基因算法产生的测试信号如预期的一样具有最小峰值,但当把这两个测试信号输入到识别工具箱之后,估计系统的矩阵特征值与原始系统的矩阵特征值有很大的差距.产生这种差异的原因主要有两个,一个可能是产生这两个测试信号的长度不够,另一个可能是这两个测试信号非正交.     

浅析专利通知书打印发文流程中的问题及对策

介绍了专利通知书的打印发文流程,分析了专利通知书打印发文流程中存在的问题,探讨了提升专利通知书打印发文工作质量的对策。     

人影弹药安全存储报警装置研制

为解决基层人影作业点弹药安全存储问题,笔者开发研制了人影弹药安全存储报警装置,系统以三星ARM9 32位嵌入式RISC CPU S3C2410A处理器为硬件核心,根据报警装置需要实现的功能,添加适当的外围电路,主程序以嵌入式LINUX2.6.28作为操作系统而开发的具有远程报警、数据、监控画面上传等功能的报警系统。