RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease

Receptor for AGE (RAGE) is a member of the immunoglobulin superfamily that engages distinct classes of ligands. The biology of RAGE is driven by the settings in which these ligands accumulate, such as diabetes, inflammation, neurodegenerative disorders and tumors. In this review, we discuss the context of each of these classes of ligands, including advance glycation end-products, amyloid beta peptide and the family of beta sheet fibrils, S100/calgranulins and amphoterin. Implications for the role of these ligands interacting with RAGE in homeostasis and disease will be considered.     

融多媒体教学于传统教学,提升教学质量

多媒体教学是一种新型的现代化教学方式,在激发学生兴趣、提高教学质量上有着传统教学无法比拟的优势。作为其应用之一的多媒体课件,其制作质量直接影响课堂效果。文中以电子科技大学通信学院的《通信原理》课程为例,以多媒体课件的制作理念为主题,从面对学生的问卷调查入手,阐述了运用多媒体教学的必要性和迫切性,提出针对本课程的多媒体课件制作原则和相应的评价标准,旨在和各位教师探讨提高教学质量的措施和方法。     

Effect of Mg substitution for La on microstructure, hydrogen storage and electrochemical properties of La1−xMgxNi3.5 (x=0.20, 0.23, 0.25 at%) alloys

The effect of Mg substitution for La on microstructure, hydrogen storage and electrochemical properties of the annealed La_(1-x) Mg_x Ni_3.5(x=0.20, 0.23, 0.25 at%) alloys have been studied. All the samples were mainly composed of(LaMg)_2Ni_7,(LaMg)Ni_3, and LaNi_5 phases. Mg substitution for La changed the phase abundance, but did not change the constitution of all phases, which is con fi rmed by the results of backscattered SEM images and EDS analysis. The P–C isotherms indicated that the La_(1-x) Mg_x Ni_3.5alloys reversibly absorbed and desorbed hydrogen smoothly at 298 K. The hydrogen absorption cyclic stabilities of La_(1-x) Mg_x Ni_3.5alloy after 5 hydrogen absorption/desorption cycles reached the maximum values of91.9% and 96.0% at 298 K and 323 K, respectively. The hydrogen desorption capacity and plateau pressure for the La_(1-x) Mg_x Ni_3.5alloy reached the maximum values of 1.055 H/M and 0.074 MPa, respectively. The desorption capacities of La_(1-x) Mg_x Ni_3.5reached 0.193 H/M and 0.565 H/M in the fi rst minute at 298 K and 323 K, respectively. Electrochemical property measurement indicated that La_(1-x) Mg_x Ni_3.5(x=0.20,0.23, 0.25 at%) alloys possessed excellent activation capability and were completely activated within3 cycles. Discharge capacities of La_(1-x) Mg_x Ni_3.5alloys reached 378.2 m A h/g(x = 0.20 at%), 342.7 m A h/g(x = 0.23 at%), and 369.6 m A h/g(x = 0.25 at%), respectively. Moreover, energy density of La_(1-x) Mg_x Ni_3.5alloy was much larger than that of La_0.80Mg_0.20Ni_3.5 alloy and nearly approaches the maximum value of La0.75Mg0.25Ni3.5. Thus, the La_(1-x) Mg_x Ni_3.5alloy exhibits optimum comprehensive properties of hydrogen storage and electrochemistry.     

An ERP study for the degrees of the difficulty in visual search

The present study mainly probed the relationships between ERP components and the degrees of difficulty in visual search. Three experimental and one controlled conditions were randomly selected. Results showed that the P1, N1, and P2 amplitudes and latencies had no significant differences among the three experimental and one controlled conditions, and the ERP waveforms of low perceptual load of visual search were different from that of high perceptual load. These results might indicate that the latencies and amplitudes of initial P1, N1 and P2 in high and low perceptual load conditions were almost the same. The ERP waveforms of parallel search were very different from that of serial search, and the ERP waveforms of serial search were very similar. The P3 amplitudes increased as the degrees of the difficulty in visual search decreased.     

断氧,再给氧对萌发绿豆超弱发光的影响

无论是用氮气法还是用水浸法造成萌发绿豆断绝氧气时其超弱发光(PE)都会大幅度下降,接近本底.当重新给氧时.萌发绿豆的PE立即上升,超过正常时的PE强度,随后才逐渐下降,最后接近正常时的发光水平,形成PE峰.PE峰值随着断氧时间的增加而增大,断氧半小时,已出现明显的峰值;断氧20小时后,PE峰值不再增大、出现饱合.     

孤东油田上第三系馆陶组上段微量元素的分布特征及沉积环境分析

通过对孤东油田馆上段四日进109块岩样中的Ca,Mg,Sr,Cr.Cu,Fe,Mn,V,Ni等九种元素的分析,得出了孤东油田馆陶组上段微量元素含量及其比值与氧化还原、湖盆盐度、古气候等沉积条件的关系,从而提供了利用微量元素及其比值的变化分析沉积环境,划分微相类型及判断古盐度高低的一种新方法.     

调频步进雷达回波实时数字生成的一种新方法

突破宽带信号数字生成方法的框架 ,提出了基于波形存储和实时计算相结合的调频步进雷达回波高速实时数字生成新方法。基于某调频步进雷达系统的研究 ,提出的解决方案摆脱了传统的波形存储直读法和直接数字合成法的局限性 ,即不适应于变换参数的情况 (比如运动目标 ) ,成功地实现了运动多散射点目标回波的实时产生 ,证明方案可行。还对算法的数值稳定性进行了分析。     

基于旋翼微动雷达特征的空中目标识别

详细分析了直升机目标回波信号的多普勒谱的构成,针对直升机目标和固定翼飞机目标多普勒谱的差别,提取了两种微多普勒特征用于识别直升机目标和固定翼飞机目标,其中一种利用了直升机回波信号正负多普勒频谱能量的不对称性,另外一种利用了机身回波信号能量与旋翼回波信号能量的对比,使用仿真数据和试验测试录制的数据计算结果表明,该方法具有很好的识别效果。     

多CPU微机接口实验装置

介绍一种适用于高校微机教学的微机接口实验装置，该装置采用多ＣＰＵ设计，可完成不同ＣＰＵ控制下的１６位及８位微机接口实验。     

基于大脑情感学习的转台逆模型补偿控制

针对传统控制方法难以克服飞行仿真转台伺服系统中存在的摩擦等非线性干扰力矩问题,提出了一种基于大脑情感学习(brain emotional learning, BEL)模型的转台伺服系统复合控制方法. 在传统PI反馈控制器的基础上,设计了基于BEL模型的同结构系统逆模型辨识器和前馈补偿控制器. 通过在线辨识系统逆模型来学习BEL模型的节点权值. 理想转台模型的数值仿真和实际转台伺服系统的实验结果都表明：BEL模型学习能力强,能满足实时控制要求,基于BEL模型的复合控制策略能有效抑制摩擦力矩的影响,提高转台系统的跟踪性能.