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排序方式: 共有135条查询结果,搜索用时 15 毫秒
111.
112.
Fibronectins--adhesive glycoproteins of cell surface and blood. 总被引:79,自引:0,他引:79
A recently characterised class of adhesive, high molecular weight glycoproteins is present on the surfaces of cells, in connective tissue matrices, and in extracellular fluids. These proteins may have important roles in cellular adhesion, malignant transformation, reticuloendothelial system function, and embryonic differentiation. 相似文献
113.
Zusammenfassung Mit Hilfe von radioaktiv markiertem Leucin wird gezeigt, dass das Mesoderm seine Induktionswirkung auf das Ectoderm ausübt, bevor histogenetische Differenzierung einsetzt.
This research was supported by the U.S. Atomic Energy Commission under contract with the Union Carbide Corporation.S. K. Brahma was a Damon Runyon Memorial Fund fellow. 相似文献
This research was supported by the U.S. Atomic Energy Commission under contract with the Union Carbide Corporation.S. K. Brahma was a Damon Runyon Memorial Fund fellow. 相似文献
114.
Electron microscopic examination of the developing ovary of 15-20-day chick embryos revealed that the interstital cells well innervated. Nerve fibres and nerve endings were observed in close contact with steroid-producing cells. 相似文献
115.
The effects of adrenalectomy or nephrectomy, carried out one hour previously, on the levels of endogenous digitalis-like factors were determined in rat plasma. Factors were assayed by digoxin-like immunoreactivity and direct Na+,K(+)-ATPase inhibitory activity. Digoxin-like immunoreactivity significantly decreased one hour after bilateral ablation of adrenals, while Na+,K(+)-ATPase inhibitory activity remained unaltered. There were no changes in either activity one hour after bilateral nephrectomy. These results suggest that digoxin-like immunoreactivity may be derived from the adrenal gland or under adrenal control and the major substances detected by digoxin-like immunoreactivity and direct Na+,K(+)-ATPase inhibitory activity may be different. 相似文献
116.
117.
Avian flu: isolation of drug-resistant H5N1 virus 总被引:1,自引:0,他引:1
Le QM Kiso M Someya K Sakai YT Nguyen TH Nguyen KH Pham ND Ngyen HH Yamada S Muramoto Y Horimoto T Takada A Goto H Suzuki T Suzuki Y Kawaoka Y 《Nature》2005,437(7062):1108
The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug. 相似文献
118.
Chen YH Li MH Zhang Y He LL Yamada Y Fitzmaurice A Shen Y Zhang H Tong L Yang J 《Nature》2004,429(6992):675-680
High-voltage-activated Ca2+ channels are essential for diverse biological processes. They are composed of four or five subunits, including alpha1, alpha2-delta, beta and gamma (ref. 1). Their expression and function are critically dependent on the beta-subunit, which transports alpha1 to the surface membrane and regulates diverse channel properties. It is believed that the beta-subunit interacts with alpha1 primarily through the beta-interaction domain (BID), which binds directly to the alpha-interaction domain (AID) of alpha1; however, the molecular mechanism of the alpha1-beta interaction is largely unclear. Here we report the crystal structures of the conserved core region of beta3, alone and in complex with AID, and of beta4 alone. The structures show that the beta-subunit core contains two interacting domains: a Src homology 3 (SH3) domain and a guanylate kinase (GK) domain. The AID binds to a hydrophobic groove in the GK domain through extensive interactions, conferring extremely high affinity between alpha1 and beta-subunits. The BID is essential both for the structural integrity of and for bridging the SH3 and GK domains, but it does not participate directly in binding alpha1. The presence of multiple protein-interacting modules in the beta-subunit opens a new dimension to its function as a multi-functional protein. 相似文献
119.
A previously unidentified MECP2 open reading frame defines a new protein isoform relevant to Rett syndrome 总被引:17,自引:0,他引:17
Mnatzakanian GN Lohi H Munteanu I Alfred SE Yamada T MacLeod PJ Jones JR Scherer SW Schanen NC Friez MJ Vincent JB Minassian BA 《Nature genetics》2004,36(4):339-341
Rett syndrome is caused by mutations in the gene MECP2 in approximately 80% of affected individuals. We describe a previously unknown MeCP2 isoform. Mutations unique to this isoform and the absence, until now, of identified mutations specific to the previously recognized protein indicate an important role for the newly discovered molecule in the pathogenesis of Rett syndrome. 相似文献
120.
Yamada K Andrews C Chan WM McKeown CA Magli A de Berardinis T Loewenstein A Lazar M O'Keefe M Letson R London A Ruttum M Matsumoto N Saito N Morris L Del Monte M Johnson RH Uyama E Houtman WA de Vries B Carlow TJ Hart BL Krawiecki N Shoffner J Vogel MC Katowitz J Goldstein SM Levin AV Sener EC Ozturk BT Akarsu AN Brodsky MC Hanisch F Cruse RP Zubcov AA Robb RM Roggenkäemper P Gottlob I Kowal L Battu R Traboulsi EI Franceschini P Newlin A Demer JL Engle EC 《Nature genetics》2003,35(4):318-321
Congenital fibrosis of the extraocular muscles type 1 (CFEOM1; OMIM #135700) is an autosomal dominant strabismus disorder associated with defects of the oculomotor nerve. We show that individuals with CFEOM1 harbor heterozygous missense mutations in a kinesin motor protein encoded by KIF21A. We identified six different mutations in 44 of 45 probands. The primary mutational hotspots are in the stalk domain, highlighting an important new role for KIF21A and its stalk in the formation of the oculomotor axis. 相似文献