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排序方式: 共有157条查询结果,搜索用时 31 毫秒
111.
刘忠 张玉虎 马英君 Y.Sasaki K.Yamada H.Oshima H.Yokose M.Ishizuka T.Komatsubara K.Furuno 《中国科学(G辑)》2003,33(1):27-33
利用在束γ谱学方法, 通过124Sn (7Li, α2n)反应研究了125Sb的激发态, 首次建立了125Sb的高自旋能级纲图, 其中包括21条新 γ 跃迁和14个新能级. 发现1970, 2110和2470 keV 3个能级为同质异能态, 基于延迟符合测量确定了它们的寿命范围, 并确定其自旋、宇称分别为15/2-, 19/2-和23/2+. 根据粒子-核芯耦合图像和经验壳模型计算解释了125Sb的能级结构, 3个同质异能态的组态分别被指定为πg7/2 Äv(h11/2s1/2)5- , πg7/2 Ä v(h11/2d3/2)7-, 和πg7/2 Äv(h211/2)10+ 相似文献
112.
H. Matsuoka K. Yamada K. Atarashi M. Takagi T. Sugimoto 《Cellular and molecular life sciences : CMLS》1990,46(7):726-728
Summary To investigate the roles of adenosine A1 and A2 receptors in the regulation of aldosterone production, we examined the effects of adenosine and adenosine agonists (N6-cyclohexyl adenosine; selective adenosine A1 receptor agonist and 5-N-ethylcarboxamine adenosine; selective adenosine A2 receptor agonist) on aldosterone and cyclic AMP production in rat adrenal capsular cells. Neither adenosine nor 5-N-ethylcarboxamine adenosine caused significant effects on basal aldosterone or cyclic AMP production. Also, adenosine (10–3M) showed no consistent effects on aldosterone and cyclic AMP production induced by ACTH. On the other hand, N6-cyclohexyl adenosine exhibited a significant inhibition of basal aldosterone and cyclic AMP production at doses of 10–4 M and 10–3 M; furthermore, 10–3 M N6-cyclohexyl adenosine inhibited aldosterone and cyclic AMP production stimulated by ACTH. These results suggest that adenosine A1 receptors are coupled to and inhibit adenylate cyclase and may be involved in the inhibition of aldosterone production. 相似文献
113.
Synthesis and some characteristics of [13C]-specially enriched tetragastrin and the related compound
S. Yamada M. Sakagami N. Yanaihara H. Nishikawa H. Watari 《Cellular and molecular life sciences : CMLS》1977,33(12):1566-1567
Summary [13C]-enriched tetragastrin and the related compound were synthesized in solution. Conversion of S-[13C]-methylated tetragastrin to the enriched tetragastrin gave 10.5 ppm upfield chemical shift of C resonance. The potency of the synthetic tetragastrin to stimulate gastric acid secretion was virtually identical with that of pentagastrin (ICI).Acknowledgment. A part of this research was supported by scientific research funds (No. 944059, 048253) from the Japanese Ministry of Education. 相似文献
114.
C Masutani R Kusumoto A Yamada N Dohmae M Yokoi M Yuasa M Araki S Iwai K Takio F Hanaoka 《Nature》1999,399(6737):700-704
Xeroderma pigmentosum variant (XP-V) is an inherited disorder which is associated with increased incidence of sunlight-induced skin cancers. Unlike other xeroderma pigmentosum cells (belonging to groups XP-A to XP-G), XP-V cells carry out normal nucleotide-excision repair processes but are defective in their replication of ultraviolet-damaged DNA. It has been suspected for some time that the XPV gene encodes a protein that is involved in trans-lesion DNA synthesis, but the gene product has never been isolated. Using an improved cell-free assay for trans-lesion DNA synthesis, we have recently isolated a DNA polymerase from HeLa cells that continues replication on damaged DNA by bypassing ultraviolet-induced thymine dimers in XP-V cell extracts. Here we show that this polymerase is a human homologue of the yeast Rad30 protein, recently identified as DNA polymerase eta. This polymerase and yeast Rad30 are members of a family of damage-bypass replication proteins which comprises the Escherichia coli proteins UmuC and DinB and the yeast Rev1 protein. We found that all XP-V cells examined carry mutations in their DNA polymerase eta gene. Recombinant human DNA polymerase eta corrects the inability of XP-V cell extracts to carry out DNA replication by bypassing thymine dimers on damaged DNA. Together, these results indicate that DNA polymerase eta could be the XPV gene product. 相似文献
115.
通过剖析傣族孔雀舞的事例来研究中国政府的文艺政策是以何种形式与少数民族的文化传统相结合,并在社会主义体制下如何参与展示民族形象的。认为中国共产党为了使统一的多民族的国家形象化,所以想通过民族舞蹈改变人们对少数民族既存的形象和想象,并期待民族舞蹈对展示的"想象的共同体"发挥积极的作用。 相似文献
116.
Resistance to viomycin conferred by RNA of either ribosomal subunit. 总被引:15,自引:0,他引:15
117.
E-cadherin plays an essential role in collective directional migration of large epithelial sheets 总被引:1,自引:1,他引:0
Li L Hartley R Reiss B Sun Y Pu J Wu D Lin F Hoang T Yamada S Jiang J Zhao M 《Cellular and molecular life sciences : CMLS》2012,69(16):2779-2789
In wound healing and development, large epithelial sheets migrate collectively, in defined directions, and maintain tight cell-cell adhesion. This type of movement ensures an essential function of epithelia, a barrier, which is lost when cells lose connection and move in isolation. Unless wounded, epithelial sheets in cultures normally do not have overall directional migration. Cell migration is mostly studied when cells are in isolation and in the absence of mature cell-cell adhesion; the mechanisms of the migration of epithelial sheets are less well understood. We used small electric fields (EFs) as a directional cue to instigate and guide migration of epithelial sheets. Significantly, cells in monolayer migrated far more efficiently and directionally than cells in isolation or smaller cell clusters. We demonstrated for the first time the group size-dependent directional migratory response in several types of epithelial cells. Gap junctions made a minimal contribution to the directional collective migration. Breaking down calcium-dependent cell-cell adhesion significantly reduced directional sheet migration. Furthermore, E-cadherin blocking antibodies abolished migration of cell sheets. Traction force analysis revealed an important role of forces that cells in the leading rows exert on the substratum. With EF, the traction forces of the leading edge cells coordinated in directional re-orientation. Our study thus identifies a novel mechanism--E-cadherin dependence and coordinated traction forces of leading cells in collective directional migration of large epithelial sheets. 相似文献
118.
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population 总被引:1,自引:0,他引:1
Okada Y Terao C Ikari K Kochi Y Ohmura K Suzuki A Kawaguchi T Stahl EA Kurreeman FA Nishida N Ohmiya H Myouzen K Takahashi M Sawada T Nishioka Y Yukioka M Matsubara T Wakitani S Teshima R Tohma S Takasugi K Shimada K Murasawa A Honjo S Matsuo K Tanaka H Tajima K Suzuki T Iwamoto T Kawamura Y Tanii H Okazaki Y Sasaki T Gregersen PK Padyukov L Worthington J Siminovitch KA Lathrop M Taniguchi A Takahashi A Tokunaga K Kubo M Nakamura Y Kamatani N Mimori T Plenge RM Yamanaka H Momohara S Yamada R 《Nature genetics》2012,44(5):511-516
Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation. We report a meta-analysis of genome-wide association studies (GWAS) in a Japanese population including 4,074 individuals with rheumatoid arthritis (cases) and 16,891 controls, followed by a replication in 5,277 rheumatoid arthritis cases and 21,684 controls. Our study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10(-8), including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2. ANXA3 was also associated with susceptibility to systemic lupus erythematosus (P = 0.0040), and B3GNT2 and ARID5B were associated with Graves' disease (P = 3.5 × 10(-4) and 2.9 × 10(-4), respectively). We conducted a multi-ancestry comparative analysis with a previous meta-analysis in individuals of European descent (5,539 rheumatoid arthritis cases and 20,169 controls). This provided evidence of shared genetic risks of rheumatoid arthritis between the populations. 相似文献
119.
Obesity is a multifactorial and heterogeneous condition that results from alterations of various genes, each having a partial
and additive effect. The inheritance pattern of obesity is thus complex, and environmental factors play an important role
in promoting or delaying its development. The identification of susceptibility genes and genetic variants for obesity requires
various methodological approaches. Obesity is classified into three main categories on the basis of genetic etiology: monogenic,
syndromic, and polygenic obesity. Here we review monogenic and syndromic obesity. We also review the linkage analysis studies
followed by the candidate gene approaches and genome-wide association studies. Identification of the underlying genetic causes
of obesity will likely provide a basis both for the development of new therapeutic agents and for the personalized prevention
of this condition.
Received 2 October 2007; received after revision 15 November 2007; accepted 19 November 2007 相似文献
120.
Yasuda K Miyake K Horikawa Y Hara K Osawa H Furuta H Hirota Y Mori H Jonsson A Sato Y Yamagata K Hinokio Y Wang HY Tanahashi T Nakamura N Oka Y Iwasaki N Iwamoto Y Yamada Y Seino Y Maegawa H Kashiwagi A Takeda J Maeda E Shin HD Cho YM Park KS Lee HK Ng MC Ma RC So WY Chan JC Lyssenko V Tuomi T Nilsson P Groop L Kamatani N Sekine A Nakamura Y Yamamoto K Yoshida T Tokunaga K Itakura M Makino H Nanjo K Kadowaki T Kasuga M 《Nature genetics》2008,40(9):1092-1097
We carried out a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The most significant association was obtained with SNPs in KCNQ1, and dense mapping within the gene revealed that rs2237892 in intron 15 showed the lowest Pvalue (6.7 x 10(-13), odds ratio (OR) = 1.49). The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations, and meta-analysis with a total of 19,930 individuals (9,569 cases and 10,361 controls) yielded a P value of 1.7 x 10(-42) (OR = 1.40; 95% CI = 1.34-1.47) for rs2237892. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion according to the homeostasis model assessment of beta-cell function or the corrected insulin response. Our data thus implicate KCNQ1 as a diabetes susceptibility gene in groups of different ancestries. 相似文献