全文获取类型
收费全文 | 149篇 |
免费 | 0篇 |
专业分类
系统科学 | 1篇 |
现状及发展 | 52篇 |
研究方法 | 25篇 |
综合类 | 70篇 |
自然研究 | 1篇 |
出版年
2016年 | 1篇 |
2015年 | 1篇 |
2013年 | 1篇 |
2012年 | 8篇 |
2011年 | 7篇 |
2009年 | 1篇 |
2008年 | 6篇 |
2007年 | 9篇 |
2006年 | 16篇 |
2005年 | 3篇 |
2004年 | 5篇 |
2003年 | 9篇 |
2002年 | 3篇 |
2001年 | 6篇 |
2000年 | 6篇 |
1999年 | 4篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1995年 | 3篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1990年 | 8篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1985年 | 3篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1979年 | 2篇 |
1978年 | 5篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1971年 | 4篇 |
1970年 | 1篇 |
1969年 | 2篇 |
1968年 | 6篇 |
1967年 | 2篇 |
1965年 | 1篇 |
1964年 | 1篇 |
1963年 | 1篇 |
1958年 | 1篇 |
1955年 | 1篇 |
排序方式: 共有149条查询结果,搜索用时 171 毫秒
41.
A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities 总被引:11,自引:0,他引:11
Kochi Y Yamada R Suzuki A Harley JB Shirasawa S Sawada T Bae SC Tokuhiro S Chang X Sekine A Takahashi A Tsunoda T Ohnishi Y Kaufman KM Kang CP Kang C Otsubo S Yumura W Mimori A Koike T Nakamura Y Sasazuki T Yamamoto K 《Nature genetics》2005,37(5):478-485
Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis (odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-kappaB and regulates FCRL3 expression. We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease-susceptible genotype. We also found associations between the SNP and susceptibility to autoimmune thyroid disease and systemic lupus erythematosus. FCRL3 may therefore have a pivotal role in autoimmunity. 相似文献
42.
Vega H Waisfisz Q Gordillo M Sakai N Yanagihara I Yamada M van Gosliga D Kayserili H Xu C Ozono K Jabs EW Inui K Joenje H 《Nature genetics》2005,37(5):468-470
Roberts syndrome is an autosomal recessive disorder characterized by craniofacial anomalies, tetraphocomelia and loss of cohesion at heterochromatic regions of centromeres and the Y chromosome. We identified mutations in a new human gene, ESCO2, associated with Roberts syndrome in 15 kindreds. The ESCO2 protein product is a member of a conserved protein family that is required for the establishment of sister chromatid cohesion during S phase and has putative acetyltransferase activity. 相似文献
43.
Tabata S Kaneko T Nakamura Y Kotani H Kato T Asamizu E Miyajima N Sasamoto S Kimura T Hosouchi T Kawashima K Kohara M Matsumoto M Matsuno A Muraki A Nakayama S Nakazaki N Naruo K Okumura S Shinpo S Takeuchi C Wada T Watanabe A Yamada M Yasuda M Sato S de la Bastide M Huang E Spiegel L Gnoj L O'Shaughnessy A Preston R Habermann K Murray J Johnson D Rohlfing T Nelson J Stoneking T Pepin K Spieth J Sekhon M Armstrong J Becker M Belter E Cordum H Cordes M Courtney L Courtney W Dante M Du H 《Nature》2000,408(6814):823-826
The genome of the model plant Arabidopsis thaliana has been sequenced by an international collaboration, The Arabidopsis Genome Initiative. Here we report the complete sequence of chromosome 5. This chromosome is 26 megabases long; it is the second largest Arabidopsis chromosome and represents 21% of the sequenced regions of the genome. The sequence of chromosomes 2 and 4 have been reported previously and that of chromosomes 1 and 3, together with an analysis of the complete genome sequence, are reported in this issue. Analysis of the sequence of chromosome 5 yields further insights into centromere structure and the sequence determinants of heterochromatin condensation. The 5,874 genes encoded on chromosome 5 reveal several new functions in plants, and the patterns of gene organization provide insights into the mechanisms and extent of genome evolution in plants. 相似文献
44.
Maze-solving by an amoeboid organism 总被引:1,自引:0,他引:1
45.
46.
Summary Electron microscopic examination of the developing ovary of 15–20-day chick embryos revealed that the interstitial cells were well innervated. Nerve fibres and nerve endings were observed in close contact with steroid-producing cells. 相似文献
47.
48.
49.
Regot S Macia J Conde N Furukawa K Kjellén J Peeters T Hohmann S de Nadal E Posas F Solé R 《Nature》2011,469(7329):207-211
Ongoing efforts within synthetic and systems biology have been directed towards the building of artificial computational devices using engineered biological units as basic building blocks. Such efforts, inspired in the standard design of electronic circuits, are limited by the difficulties arising from wiring the basic computational units (logic gates) through the appropriate connections, each one to be implemented by a different molecule. Here, we show that there is a logically different form of implementing complex Boolean logic computations that reduces wiring constraints thanks to a redundant distribution of the desired output among engineered cells. A practical implementation is presented using a library of engineered yeast cells, which can be combined in multiple ways. Each construct defines a logic function and combining cells and their connections allow building more complex synthetic devices. As a proof of principle, we have implemented many logic functions by using just a few engineered cells. Of note, small modifications and combination of those cells allowed for implementing more complex circuits such as a multiplexer or a 1-bit adder with carry, showing the great potential for re-utilization of small parts of the circuit. Our results support the approach of using cellular consortia as an efficient way of engineering complex tasks not easily solvable using single-cell implementations. 相似文献
50.