面向产品市场周期的配件需求预测与供应策略

针对机电产品市场周期中配件需求预测与供应问题,应用系统工程方法,基于机电产品及其易损耗零部件的失效时间分布密度函数,发展面向机电产品市场周期的机电产品配件需求预测模型,继而提出机电产品配件生产与供应策略.以机电产品及零件的寿命分布满足正态分布函数为例,通过数值仿真,分析探讨了产品及零件失效时间分布密度函数的参数和生产批量对零件替换率和配件需求量的影响;提出了基于机电产品及零件寿命正态分布的配件生产供应方案,与常规方法对比分析表明了所提出方法的优越性.这对于有效地组织配件生产和指导配件库存管理,提高机电产品维修和售后服务水平具有重要意义.     

Single-cell discrimination based on optical tweezers Raman spectroscopy

The ability to discriminate between single cells in a label-free and noninvasive fashion is important for the classification of cells, and for the identification of similar cells from different origins. In this paper, we present the Raman spectroscopy-based identifi- cation of different types of single cells in aqueous media, and discrimination between the same types of cells from different donors using a novel Laser Tweezers Raman Spectroscopy (LTRS) technique, which combines laser trapping and micro-Raman spectroscopy. First, we measured the spectra of individual living human erythrocytes, i.e. red blood cells, and leucocytes (U937 cancer cells). High-quality Raman spectra with low fluorescence were obtained using a home-LTRS apparatus and 20 cells were measured for each cell type. The smoothing, baseline subtraction, and normalization of the data were followed by a principal components analysis (PCA). The PCA loading plots showed that the two different types of cells could be completely separated based only on the first component (PC1) (i.e. the peaks at 1300 cm1 ); the discrimination accuracy could therefore reach 100%. More than 50 spectra were taken for each erythrocyte obtained from the four healthy volunteers. The average discrimination accuracy was 84.5% for two random individuals taken from the four volunteers, according to the first and second PCs. This work demonstrates that LTRS is a powerful tool for the accurate identification and discrimination of single cells, and it has the potential to be applied for the highly sensitive identification of cells in clinical diagnosis and medical jurisprudence.     

一种改进的个人综合素质模糊评价方法

提出了一种改进的个人综合素质模糊评价方法。针对传统的模糊综合评价方法中最大隶属度准则在很多情况下给出的评价结果不能客观、准确地反映一个学生的个人综合素质 ,本文找到了最大隶属度准则的不适用情况 ,并应用新的准则———置信度准则 ,有效地解决了问题 ,从而提高了模糊评价方法的评价精度 ,扩大了它的适用范围。     

Cadmium is a mutagen that acts by inhibiting mismatch repair

Most errors that arise during DNA replication can be corrected by DNA polymerase proofreading or by post-replication mismatch repair (MMR). Inactivation of both mutation-avoidance systems results in extremely high mutability that can lead to error catastrophe. High mutability and the likelihood of cancer can be caused by mutations and epigenetic changes that reduce MMR. Hypermutability can also be caused by external factors that directly inhibit MMR. Identifying such factors has important implications for understanding the role of the environment in genome stability. We found that chronic exposure of yeast to environmentally relevant concentrations of cadmium, a known human carcinogen, can result in extreme hypermutability. The mutation specificity along with responses in proofreading-deficient and MMR-deficient mutants indicate that cadmium reduces the capacity for MMR of small misalignments and base-base mismatches. In extracts of human cells, cadmium inhibited at least one step leading to mismatch removal. Together, our data show that a high level of genetic instability can result from environmental impediment of a mutation-avoidance system.     

基于PAD的个性化情感模型

基于情感计算和人工心理学理论定义了个性空间、心情空间和情感空间,并建立起了个性空间同心情空间的映射关系,提出基本情感强度的概念来描述情感空间在某一时刻所处的状态。根据心情空间中心情向量离基本情感点的距离远近关系来度量情感空间中某种情感出现的概率大小,建立起了心情空间与情感空间的映射关系,并建立了一个新的三层映射关系的个性化情感模型。通过仿真实验验证,该情感模型能较为准确地描述人类情感变化规律。     

基于Web的卫星云图信息系统研究

1　项目背景　　最近 ,我们为民航空管局开发了综合业务网络系统 .系统的基本构架是浏览器 /服务器 (Ｂ/Ｓ)模式 ,采用Ｓｕｎ公司的超级小型机作为Ｗｅｂ服务器和数据库服务器 ,操作系统为ＳｕｎＳｏｌａｒｉｓ 8;Ｗｅｂ服务器程序使用Ａ ｐａｃｈｅ ,开发语言使用ＰＨＰ和Ｊａｖａ ;数据库系统采用Ｏｒａｃｌｅ 8.1.6ＥｎｔｅｒｐｒｉｓｅＥｄｉｔｉｏｎ .综合业务网络系统的主要功能 ,是将空管局目前几个单独运行的业务系统信息综合起来 ,为空管局的日常工作以及航空公司和驻场单位等业务数据用户提供及时、准确、综合的信息 .其中一项重…     

竞技体育文化的几点内涵探析

竞技体育是一种特殊的体育文化现象,以竞技体育文化为内核的奥林匹克运动超越了一般体育文化的范畴,成为社会发展的主流文化,更说明了竞技体育文化的特殊性。随着现代社会的整体进步,竞技将更贴近人性,更能表现人类最原始、最本质的力量与价值,存在方式与独立尊严。此文从竞技体育的文化本质、竞技体育文化的民族精神、竞技体育文化的人本思想三个方面探讨了这种崭新并不断完善的文化体系,为更深入地分析竞技体育文化的内涵提供一些参考。     

具有不确定性输出的决策单元的相对效益评价

针对一类输出受干扰影响的多输入多输出社会经济系统的效益评价问题,研究了数据包络分析方法中决策单元的有效性、P-生产可能集以及原始性等概念,定义了一个可用于判断输出受随机因素影响的决策单元相对有效程度的指标,并在此基础上给出了一个新的随机DEA评价模型,分析了该模型的性质、求解方法以及与现有模型的一致性等,最后给出了一个评价案例.     

微毛诃子树皮醇提取液半数致死量的测定及对肠肌的作用

目的:研究微毛诃子树皮醇提取液对小鼠的半数致死量(LD50)以及在体肠肌的影响,并且观察其对豚鼠离体肠肌的影响。方法:按Bliss法设计实验,对小鼠灌胃给药,观察5 d内小鼠的毒性反应和死亡情况,以小鼠急性死亡率为指标,测定微毛诃子提取液对小鼠的LD50;采用炭末推进实验观察药物对在体肠肌的影响;以豚鼠离体肠肌收缩幅度、张力为指标,采用离体标本运动实验法观察微毛诃子树皮醇提液对豚鼠离体肠肌的影响及其作用机制。结果:微毛诃子树皮提取液小鼠灌胃给药的LD50为5.69 g/kg,LD50的95%的可信限为4.60~7.05 g/kg;微毛诃子树皮的醇提液对小鼠在体肠肌和豚鼠离体肠肌都具有明显的舒张作用,且组胺对微毛诃子树皮的醇提液的抑制作用具有拮抗作用。结论:微毛诃子树皮的醇提取液具有一定的毒性,同时微毛诃子树皮醇提液能在一定程度上抑制肠肌的收缩,且作用机制可能与阻断组织胺受体有关。     

2-取代芳基苯并咪唑-Cu(Ⅱ)络合物的研究

合成了3种2-取代芳基苯并咪唑- Cu(Ⅱ)络合物,通过苯并咪唑与Cu(Ⅱ)反应前后红外光谱解析,表明二者发生了络合反应;采用摩尔比法测定了该络合反应的配位数、X射线衍射测定了络合物的结构,确定了该络合物中心原子Cu(Ⅱ)和配体苯并咪唑分子的空间构型.