分布式公路交通量数据服务中心的设计与实现

所探讨的分布式交通量数据服务中心由3个数据库和4个独立子系统组成.分析了数据服务中心的需求特点、总体功能和系统构成,介绍了数据库表的结构和子系统的功能,描述了基于.NET的多线程、异步Socket及其资源释放、Web服务及Excel报表制作等实现技术.实际运行表明,该分布式系统有较好的稳定性与健壮性,满足了公路管理部门的需求.     

多维光纤通信系统性能监测技术

目前光纤通信系统正朝着超高速、大容量、动态化方向快速发展,新的维度和复用方式以及更加复杂的体系架构对光纤传送网安全可靠运行提出了巨大的挑战.多维光纤通信系统中的性能监测技术能对系统所受损伤进行监测与预警,为自适应补偿、传输质量评估和网络资源优化等提供信息来源和管理依据,对提升光纤传送网运行和管理水平具有重要的科学意义和社会意义.该文首先重点介绍色散参量监测、非线性参量监测、调制格式参量监测等多个参量监测的研究现状,随后讨论并分析了多维光纤通信系统性能监测技术的发展趋势.未来性能监测技术将朝着精细化、一体化、智能化、多参量同步监测等方向发展.     

钢筋混凝土桥墩抗震耗能试验及震害破坏等级的分析研究

通过3种不同配箍率的钢筋混凝土桥墩模型在低周反复水平加载作用下的试验,分析了试件的破坏形式、整体变形的特征及滞回曲线、耗能系数等抗震性能,并由Park-Ang损伤模型所得出的试件损伤指数标定了试件的破坏等级。     

浅谈监理工作的规范化

由于我国监理工作起步较晚,因此其中存在许多问题与不足。如何能使监理工作健康发展,对其进行规范化显得尤为重要。结合我国国情,针对当前建设监理工作中的现状以及面临的问题,分析其成因,提出了几点改进建议,以期促进我国监理水平的提高,对于规范监理工作也具有一定的参考价值。     

加快推进高技术建筑的中国化

加快推进高技术建筑的中国化是极为迫切的,同时也需要做出更为艰巨的努力。为此首先要正确理解高技术建筑地域化的本质,它要求建筑师将建筑所处基地的地域元素贯穿于建筑设计之中。其次,应继承与发扬中国传统文化,在建筑实践中继承与发展中国的传统文化。此外,还应进一步加强对中国传统建筑技术的挖掘与现代化运用,传统技术的现代化能促进地方特色、传统文脉的有机生长,使高技术建筑在中国能发展为一个新的充满生机活力的有机体。     

微波等离子体法制备纳米钼粉

阐述用微波等离子法制备纳米金属钼粉的原理,探讨了此法制备纳米钼粉颗粒的工艺与影响因素,并以羰基钼为原料制得纳米级钼粉,平均粒径小于５０ｎｍ,还研究了钼粉在空气中的热稳定性。     

MPTP慢性帕金森病小鼠海马内氧化应激与细胞凋亡蛋白的表达

目的 观察 MPTP慢性帕金森病小鼠海马氧化应激指标及细胞凋亡相关蛋白的表达.方法 应用MPTP制备慢性帕金森病模型,观察行为学改变,Morris水迷宫实验,检测模型组和对照组小鼠海马内超氧化物歧化酶（SOD）、还原型谷胱甘肽（GSH）及丙二醛（MDA）舍量变化,以及免疫组织化学方法、RT-PCR方法、Western blot方法检测海马Bax和Bel-2蛋白表达.结果 慢性帕金森病模型小鼠行为学特点为震颤、活动减少;水迷宫实验结果提示认知功能降低;与对照组海马比较：模型组海马SOD、GSH含量均下降,而MDA含量升高（P〈0.05）;模型组海马Bax蛋白表达增高,而Bel-2蛋白表达下降（P〈0.05）.结论 氧化应激在慢性帕全森病认知功能障碍发病机制中起重要作用,而Bax和Bcl-2蛋白参与了氧化应激诱导海马神经元凋亡的调控过程.     

Genome-wide association studies of 14 agronomic traits in rice landraces

Uncovering the genetic basis of agronomic traits in crop landraces that have adapted to various agro-climatic conditions is important to world food security. Here we have identified ～ 3.6 million SNPs by sequencing 517 rice landraces and constructed a high-density haplotype map of the rice genome using a novel data-imputation method. We performed genome-wide association studies (GWAS) for 14 agronomic traits in the population of Oryza sativa indica subspecies. The loci identified through GWAS explained ～ 36% of the phenotypic variance, on average. The peak signals at six loci were tied closely to previously identified genes. This study provides a fundamental resource for rice genetics research and breeding, and demonstrates that an approach integrating second-generation genome sequencing and GWAS can be used as a powerful complementary strategy to classical biparental cross-mapping for dissecting complex traits in rice.     

Protein intrinsic disorder as a flexible armor and a weapon of HIV-1

Many proteins and protein regions are disordered in their native, biologically active states. These proteins/regions are abundant in different organisms and carry out important biological functions that complement the functional repertoire of ordered proteins. Viruses, with their highly compact genomes, small proteomes, and high adaptability for fast change in their biological and physical environment utilize many of the advantages of intrinsic disorder. In fact, viral proteins are generally rich in intrinsic disorder, and intrinsically disordered regions are commonly used by viruses to invade the host organisms, to hijack various host systems, and to help viruses in accommodation to their hostile habitats and to manage their economic usage of genetic material. In this review, we focus on the structural peculiarities of HIV-1 proteins, on the abundance of intrinsic disorder in viral proteins, and on the role of intrinsic disorder in their functions.