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961.
Comparison of the localization of several muscle proteins in relaxed and contracted myofibrils. 总被引:1,自引:0,他引:1
The localization of several muscle proteins in relaxed and contracted myofibrils is compared. The morphology of the myofibrils and the behavior of these proteins was also investigated under extraction conditions. 相似文献
962.
963.
964.
965.
966.
Adenosine-induced slow ionic currents in the Xenopus oocyte 总被引:11,自引:0,他引:11
Adenosine and its 5'-phosphorylated congeners evoke specific membrane-mediated responses in excitable tissues. Available data suggest that inhibition of the target cell occurs due to hyperpolarization, and in some preparations a compound effect of ATP (excitation and inhibition) has been found. However, the ionic mechanism of the purinergic-mediated response has not been studied by standard intracellular voltage-clamping techniques. Recently, we have discovered purinergic receptors in the Xenopus oocyte, a well defined giant cell amenable to rigorous electrophysiological and biochemical studies. We report here that in these cells, adenosine-induced slow membrane responses consisted of an early depolarizing (D) transient current carried by Cl ions, followed by a steady hyperpolarizing (H) current involving K+ ions. The relative potency sequence for the D current was ATP congruent to ADP greater than AMP congruent to adenosine; this order was reversed for the H current. 相似文献
967.
Summary Selection of a strain of house flies with the pyrethroid bioresmethrin has resulted in a wide range of cross resistance to 15 other pyrethroid insecticides. 相似文献
968.
The mechanism by which insulin regulates cellular metabolism remains unknown although indirect evidence suggests that alterations in intracellular calcium are important. More specifically, it has been proposed that insulin triggers an increase in intracellular calcium which is responsible for the subsequent modification of metabolic activities. The cell maintains a large electrochemical gradient for ionised calcium between the cytoplasm (less than 10(-6) M, as determined for muscle and nerve) and the extracellular environment (less than 10(-3) M). The plasma membrane may, therefore, be important in the regulation of calcium homeostasis, as a slight alteration in the processes maintaining this gradient could result in marked changes in cytoplasmic calcium. One such process is the active extrusion of calcium from the cell by a high affinity calcium-stimulated ATPase (Ca2+-ATPase). Such a mechanism has been well established in red cells and is postulated in nerve, liver and muscle. We have identified a high affinity Ca2+-ATPase in a plasma membrane-enriched subcellular fraction isolated from rat adipocytes which may provide the enzymatic basis for a calcium extrusion pump. We demonstrate here that the Ca2+-ATPase is specifically inhibited by the direct addition of physiological concentrations of insulin to the direct addition of physiological concentrations of insulin to the isolated plasma membranes. This effect suggests that direct regulation of calcium homeostasis may represent an important event in the mechanism of action of insulin. 相似文献
969.
The control of contraction activation by the membrane potential 总被引:2,自引:0,他引:2
C. Caputo G. Gottschalk H. -Ch. Lüttgau 《Cellular and molecular life sciences : CMLS》1981,37(6):580-581
Summary Force measurements under voltage-clamp control were performed in short toe muscles of the frog. The results show a) that the activation of force development and its repriming process can at least qualitatively be correlated to charge movement kinetics; b) that caffeine improves EC coupling by potentiating the potential dependent activation process.This work was supported by DFG (SFB 114 Bionach) and DAAD. 相似文献
970.
Glucose-phosphorylating enzyme with high Km in human brain 总被引:1,自引:0,他引:1
H S Bachelard 《Nature》1967,215(5104):959-960