SoC处理器的时钟生成器：电路和体系结构

本书涵盖了面向SoC（System　on　Chip，片上系统）处理器的集成综合器电路设计的论题，采取了一种更为全局的设计观念来考察电路级和体系结构级的设计空间。书中的论述十分广泛，而且包括电路理论和锁相环反馈控制理论的综述。在电路级方面，讨论包括深亚微米数字CMOS过程的低功耗模拟设计、供电噪声效应、设备噪声；在体系结构级方面的论述，涵盖了连续时间和离散时间模型的锁相环分析，以及锁相行为的细节分析。还有一些章节对特定的时钟生成器模块做了电路级和系统结构级的深入描述，其中包括高供电噪声屏蔽的锁相环电路、体系结构和数字锁相环体系结构，考察了为离散时间模拟部件产生低失真采样时钟的方法。这里所说的锁相环包括希格马．代尔塔N分锁相环、直接数字综合（DDS、Direct　Digital　Synthesis）技术和锁相环的非常规应用。本书讨论的面向测试的设计（Dvr、Design　for　Test），其中包括锁相环的精确测量滤波器方法和嵌人式测试（BIST、Built—in—self-test）技术。     

北祁连山榴辉岩锆石SHRIMP定年及其构造意义

应用阴极发光和离子探针技术, 对北祁连山高压变质带两个榴辉岩样品中的锆石进行了结构和形态学观察以及原位U-Pb定年. 所获得的年龄值分别为463 ± 6 和468 ± 13 Ma, 代表了本区榴辉岩相变质时代. 这是北祁连山加里东期高压变质作用的最早记录, 可能代表了大洋板块俯冲进入上地幔经受榴辉岩相变质的时间.     

Erratum to: Hesperomyces virescens (Fungi,Ascomycota, Laboulbeniales) attacking Harmonia axyridis (Coleoptera,Coccinellidae) in its native range

正Published online:14 March 2014óScience China Press and Springer-Verlag Berlin Heidelberg 2014Erratum to:Chin.Sci.Bull.(2014)59(5–6):528–532DOI 10.1007/s11434-013-0060-1In the original publication of this paper,the first name and the last name of the first author has been documented     

关于太平洋安全的中欧对话：展望太平洋：看得到合作的希望吗？

太平洋地区正呈现出紧张局势，这不仅体现在关键的中美关系上，而且也体现在中国与其东部和南中国海周边国家的关系上。正如白宫、美国外交部和五角大楼在2012年初正式宣布且具体实施的那样，美国注意力、行动和军力分配向太平洋地区的“再平衡”战略转移，及此战略背后的真实意图，都引起北京方面的关注。中国担心，美国从大西洋到太平洋的整体“战略转移”，     

分析系统动力学 建模与仿真

本书是结合分析力学和系统动力学发展起来的一种新的多学科动力学系统建模方法。这种新的建模技术基于拉格朗日能量法，依次生成一系列适合数值积分的微分代数方程。本书适用的建模方法是能建模和仿真的六连杆闭链机构或晶体管功率放大器等系统。     

基于OBB层次结构碰撞检测的改进算法

方向包围盒（Oriented bounding box：OBB）的构造以及包围盒的相交测试的计算量都比较大，严重影响了在模拟、仿真的应用，尤其是有变形物体的场景。引入近似凸包的思想提出一种快速构造方向包围盒算法，很大程度上减少了构造方向包围盒（0BB）层次结构的顶点数，改进后的算法在降低构造层次结构时间的同时，对方向包围盒的紧密性代价几乎没有影响，在有些时候还提高了包围盒的紧密性。在包围盒相交测试方面，提留了一种基于筒单羽以爱的相交须刿方击，该算法在检测过程中省去了大量包围盒的相交测试计算，提高了相交测试的速度。最后将两种改进算法联合的碰撞检测框架与常用的基于均值和协方差矩阵的包围盒构造和基于分裂轴的算法进行比较，证明了算法具有高效性。     

South-polar features on Venus similar to those near the north pole

Venus has no seasons, slow rotation and a very massive atmosphere, which is mainly carbon dioxide with clouds primarily of sulphuric acid droplets. Infrared observations by previous missions to Venus revealed a bright 'dipole' feature surrounded by a cold 'collar' at its north pole. The polar dipole is a 'double-eye' feature at the centre of a vast vortex that rotates around the pole, and is possibly associated with rapid downwelling. The polar cold collar is a wide, shallow river of cold air that circulates around the polar vortex. One outstanding question has been whether the global circulation was symmetric, such that a dipole feature existed at the south pole. Here we report observations of Venus' south-polar region, where we have seen clouds with morphology much like those around the north pole, but rotating somewhat faster than the northern dipole. The vortex may extend down to the lower cloud layers that lie at about 50 km height and perhaps deeper. The spectroscopic properties of the clouds around the south pole are compatible with a sulphuric acid composition.     

Structural basis for cofactor-independent dioxygenation in vancomycin biosynthesis

Enzyme-catalysed oxidations are some of the most common transformations in primary and secondary metabolism. The vancomycin biosynthetic enzyme DpgC belongs to a small class of oxygenation enzymes that are not dependent on an accessory cofactor or metal ion. The detailed mechanism of cofactor-independent oxygenases has not been established. Here we report the first structure of an enzyme of this oxygenase class in complex with a bound substrate mimic. The use of a designed, synthetic substrate analogue allows unique insights into the chemistry of oxygen activation. The structure confirms the absence of cofactors, and electron density consistent with molecular oxygen is present adjacent to the site of oxidation on the substrate. Molecular oxygen is bound in a small hydrophobic pocket and the substrate provides the reducing power to activate oxygen for downstream chemical steps. Our results resolve the unique and complex chemistry of DpgC, a key enzyme in the biosynthetic pathway of an important class of antibiotics. Furthermore, mechanistic parallels exist between DpgC and cofactor-dependent flavoenzymes, providing information regarding the general mechanism of enzymatic oxygen activation.     

The Rab8 GTPase regulates apical protein localization in intestinal cells

A number of proteins are known to be involved in apical/basolateral transport of proteins in polarized epithelial cells. The small GTP-binding protein Rab8 was thought to regulate basolateral transport in polarized kidney epithelial cells through the AP1B-complex-mediated pathway. However, the role of Rab8 (Rab8A) in cell polarity in vivo remains unknown. Here we show that Rab8 is responsible for the localization of apical proteins in intestinal epithelial cells. We found that apical peptidases and transporters localized to lysosomes in the small intestine of Rab8-deficient mice. Their mislocalization and degradation in lysosomes led to a marked reduction in the absorption rate of nutrients in the small intestine, and ultimately to death. Ultrastructurally, a shortening of apical microvilli, an increased number of enlarged lysosomes, and microvillus inclusions in the enterocytes were also observed. One microvillus inclusion disease patient who shows an identical phenotype to Rab8-deficient mice expresses a reduced amount of RAB8 (RAB8A; NM_005370). Our results demonstrate that Rab8 is necessary for the proper localization of apical proteins and the absorption and digestion of various nutrients in the small intestine.