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961.
FANGJianwu HUANGSiluo LIUHuisheng M.Crepin XUTao LIUJianfeng 《科学通报(英文版)》2003,48(15):1539-1547
Fibroblast growth factor-2 (FGF-2) is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types. It has been proved that FGF-2 stimulates the growth and development of new blood vessels (angiogenesis) that contribute to the pathogenesis of several diseases (i.e. cancer, atherosclerosis). However, many of the biological activities of FGF-2 have been found to depend on its receptor抯 intrinsic tyrosine kinase activity and second messengers such as the mitogen activated protein kinases. This review will focus on the mechanism of FGF-2/FGFR induced signaling pathway in tumor and human breast cancer. 相似文献
962.
LEI Ming YAO Baoli CHEN Yi HAN Yong WANG Yingli MENKE Neimule ZHENG Yuan WANG Congmin FAN Meigong & CHEN Guofu . State Key Laboratory of Transient Optics Technology Xi抋n Institute of Optics Precision Mechanics Chinese Academy of Sciences Xi抋n China . Technical Institute of Physics Chemistry Chinese Academy of Sciences Beijing China Correspondence should be addressed to Yao Baoli 《科学通报(英文版)》2003,48(15):1548-1550
The optical storage characteristics of a new kind of organic photochromic material棗pyrrylfulgide were experimentally investigated in the established parallel optical data storage system. Using the pyrrylfulgide/PMMA film as a photon-mode recording medium, micro-images and encoded binary digital data were recorded, readout and erased in this parallel system. The storage density currently reaches 3?107 bit/cm2. The recorded information on the film can be kept for years in darkness at room temperature. 相似文献
963.
SHISuhua DUYaqing D.E.Boufford GONGXun HUANGYelin HEHanghang ZHONGYang 《科学通报(英文版)》2003,48(15):1576-1580
The chloroplast gene matK and the internal transcribed spacers (ITS) of the nuclear ribosomal DNA from Schnabelia, a genus endemic to China, and 6 genera of Verbenaceae and 13 genera of Lamiaceae were sequenced. The phylogenetic signal and validity outgroups were measured and evaluated by means of the relatively apparent synapomorphy analysis (RASA). Independent and combined phylogenetic analyses for the matK and ITS sequences were performed using the maximum parsimony (MP), neighbor-joining (NJ) and maximum likelihood (ML) methods, indicating that Schnabelia oligophylla and Caryopteris terniflora form a sister-group relationship. The Caryopteris complex is not shown to be a monophyly because Trichostema, C. paniculata and C. forrestii are paraphyletic to the clade containing the remaining members of the complex. A monophyly of Ajugoideae proposed by Cantino et al., including 8 genera in this study, is strongly supported and the closest relatives of Schnabelia are in the Ajugoideae (Lamiaceae), especially near Caryopteris terniflora. The polygenetic analyses also showed that the genera of Lamiaceae and Verbenaceae sampled in this tudy are phylogenetically mixed and the genus Avicennia is distant to other genera of Verbenaceae. RASA and combined analysis can be used as effective approaches to determining the relationships among phylogenetically complex groups. 相似文献
964.
Involvement of nitric oxide in the signal transduction of salicylic acid regulating stomatal movement 总被引:6,自引:0,他引:6
LIUXin ZHANGShuqiu LOUChenghou 《科学通报(英文版)》2003,48(5):449-452
The effects and the relationship between sali-cylic acid(SA)and nitric oxide(NO) on Vicia faba L.stomatal movement were studied.The results here showed that exogenous SA and NO induced stomatal closure,100μmol/L SA induced a rapid and striking NO increase in the cytosol of guard cells.This phenomenon was largely prevented by 2000μmol/L 2-phenyl-4,4,5,5-tetramethylimidazoline-l-oxyl-3-oxide(PTIO),a specific NO scavenger,and 25μmol/L N^G-nitro-L-Arg-methyl eater (L-NAME),an inhibitor of NO synthase(NOS) in mammalian cells that also inhibits plant NOS.In addition,SA-induced stomatal closure was largely prevented by PTIO and L-NAME.These results provide evidence that guard cells generate NO in response to SA via NOS-like activity,and that such NO production is required for full stomatal closure in response to SA.H-(1,2,4)-oxadiazole-[4,3-α]quinoxalin-l-one(ODQ),an inhibitor of guanylate cyclase,and nicotinamide,an antagonist of cADPR production,inhibited the effects of SA-and NO-induced stomatal closure.It suggests that both cGMP and cADPR might mediate the signal transduction of SA and NO-induced stomatal closure. 相似文献
965.
This report presents experimental observations of dramatic variations in STM images of bis [1,3-DI(p-n-tetradecyloxyphenyl)propane-1,3-dionato]copper( Ⅱ) (abbreviated to C14O-Cu)physisorbed on HOPG as the bias voltage is changed .Several representative image patterns were obtained for the rich changes of the internal contrast of the molecule .Submolecular features of the molecular cores and the interdigitated alkyl parts are clearly visible. 相似文献
966.
Hydrogen storage of aligned multi-walled carbon nanotubes (a-MWNTs),non-aligned MWNTs(n-MWNTs) and graphite electrodes are studied by the electro-chemical measurements .The electrodes are prepared by mixing carbon nanotubes (CNTs) copper powder and ptfe binder in a weight ratio of 1:5:3 and compressing the mixture into porous nickel collector,The results show that the electrochemical hydrogen storage capacity of the a-MWNT electrode is up to 1625 mAh/g corresponding to a high hydrogen storage of 5.7 wt% ,which is 10 times that of graphite electrode and is 13 times that of n-MWNT electrode, suggesting that a-MWNTs are promising materials for electrochemical hydrogen storage. 相似文献
967.
Pitfalls in the analysis of ancient human mtDNA 总被引:3,自引:0,他引:3
YAOYonggang ZHANGYaping 《科学通报(英文版)》2003,48(8):826-830
The retrieval of DNA from ancient human specimens is not always successful owing to DNA deterioration and contamination although it is vital to provide new insights into the genetic structure of ancient people and to reconstruct the past history. Normally, only short DNA fragments can be retrieved from the ancient specimens. How to identify the authenticity of DNA obtained and to uncover the information it contained are difficult. We employed the ancient mtDNAs reported from Central Asia (including Xinjiang, China) as an example to discern potentially extraneous DNA contamination based on the updated mtDNA phylogeny derived from mtDNA control region, coding region, as well as complete sequence information. Our results demonstrated that many mtDNAs reported are more or less problematic.Startim, from a reliable mtDNA phylogeney and combining the available modern data into analysis, one can ascertain the authenticity of the ancient DNA, distinguish the potential errors in a data set, and efficiently decipher the meager information it harbored. The reappraisal of the mtDNAs with the age of more than 2000 years from Central Asia gave support to the suggestion of extensively (pre)historical gene admixture in this region. 相似文献
968.
GAO Lin WANG Dongyan LI Yang BU Dingfang CHANG Lin PANG Yongzheng QI Yongfen & TANG Chaoshu . Institute of Cardiovascular Disease Research Peking University First Hospital Beijing China . Department of Physiology Peking University Health Science Center Beijing China 《科学通报(英文版)》2003,48(10):983-987
Homocysteine (Hcy), a highly reactive sulfur- containing amino acid, is an intermediate product of methionine metabolism. Elevation of plasma Hcy has been widely studied as an independent risk factor for many cardiovascular diseases such as atherosclerosis, thrombosis, etc.[1]. Inherited hyperhomocysteinemia cases usually suffer from occlusion or thrombosis in arteries and large veins before the age of 20. Hyperhomocysteinemia significantly reduces the survival rate[2] and dilatation functi… 相似文献
969.
Difference in metapopulation structure and dynamics of two species of coexistent melitaeine butterflies 总被引:3,自引:0,他引:3
WANG Yifei CHEN Jiejun WANG Rongjiang LEI Guangchun & XU Rumei . Ministry of Education Key Laboratory for Biodiversity Science Ecological Engineering Beijing Normal University Beijing China . College of Life Sciences Peking University Beijing China Correspondence should be addressed to Xu Rumei 《科学通报(英文版)》2003,48(12):1239-1246
Habitat fragmentation has been considered to be the most important cause of the extinction and the loss of bio-diversity[1,2]. With the increase of human activities in re-cent years, natural habitat decreased rapidly and patches became smaller and more isolated[3,4]. This leads to an obvious change of population structure and dynamics of many species. However, some species may persist as metapopulations in seriously fragmented landscapes[5]. Metapopulation theory and methodology is estab-lish… 相似文献
970.
GU Zhaoyan LIU Qiang XU Bing HAN Jiamao YANG Shiling DING Zhongli & LIU Tungsheng Institute of Geology Geophysics Chinese Academy of Sciences Beijing China Correspondence should be addressed to Gu Zhaoyan 《科学通报(英文版)》2003,48(12):1271-1276
Two modes of photosynthesis predominate in terres-REPORTS trial plants: the C3 and C4 modes[1]. The C3 mode is used by all of trees, bushes, and cold season grasses. The C4 mode is used by the most of tropical and warm season grasses. They are disadvantaged relative to C3 plants at high CO2/O2 ratios because of the additional energy ex-pense needed to concentrate CO2 in the bundle-sheath cells. At low CO2/O2, however, C4 plants can achieve a relatively high quantum yield by suppressin… 相似文献