暗挖车站洞内地下连续墙施工导洞环境效应分析

随着城市地铁建设的迅猛发展,地铁工程建设中车站开挖大面积抽降水作业与国家保护地下水资源政策的矛盾日益突出,亟需寻求适用于地铁车站开挖的非降水止水方式。以北京地铁16号线在施暗挖车站——看丹站为依托,对其采用的洞内地下连续墙止水措施导致的环境效应开展了深入探讨。由于地下连续墙在暗挖车站局促空间内的施作尚属首例尝试,因此重点聚焦于揭示地下连续墙施工引起的导洞拱顶沉降、水平净空收敛和应力分布的变化规律。数值模拟结果表明:地下连续墙施工主要引起导洞拱顶沉降的变化,导洞水平净空收敛较为稳定;地下连续墙施工前,导洞初期支护拉应力主要在导洞拱顶处和侧壁底角处。地下连续墙施工完成后,拉应力分布范围扩大,左右边导洞初期支护底板处扩大最为明显,向地下连续墙处大致呈条带状延伸。     

固定化脂肪酶PSL/CS-MCM-48的制备及其催化性能

用壳聚糖（CS）修饰介孔分子筛MCM-48制备了复合载体CS-MCM-48,在异辛烷中制备了固定化假单胞菌脂肪酶PSL／CS-MCM-48,研究了固定化酶的制备条件对其催化性质的影响．结果表明,固定化酶PSL／CS-MCM-48适宜的制备条件为复合载体中m（CS）：m（MCM-48）=1：10,m（酶）：m（载体）=1：10,磷酸盐缓冲溶液（PBS）的pH值为6．5,V（PBS）：y（异辛烷）=1：100．固定化酶PSL／CS-MCM-48催化水解橄榄油的活性达633u／g,活力回收为55．2％,其催化活性约是PSL／MCM-48催化活性的3倍．同时考察了反应温度和反应体系的pH值对PSL／CS-MCM-48催化活性的影响规律。     

HSPF模型及其在非点源污染研究中的应用

HSPF（Hydrological SimulationProgram-Fortran）模型是将数学方法应用于水文计算和预报形成的流域水文模型,可对陆地表面、亚表面和地下水的水文路线以及污染物的输移进行模拟,广泛应用于不同尺度流域的非点源污染模拟研究,为流域管理措施的制定和实施提供有力的依据．本文总结了HSPF模型的发展过程、模型的结构特点,分析了该模型在国内外应用实例中的可靠性以及存在的问题．最后根据该模型的限制因素,指出了应用中的改进方向．     

Towards a Cost-Efcient MapReduce: Mitigating Power Peaks for HadoopClusters简

Distributed data processing system is becoming one of the most important components for data-intensive computational tasks in the enterprise software infrastructure. Deploying and operating such systems require large amount of costs, including hardware costs to build clusters and energy costs to run clusters. To make these systems sustainable and scalable, power management has been an important research problem. In this paper, we take Hadoop as an example to illustrate the power peak problem which causes power inefficiency and provides in-depth analysis to explain issues with existing system designs. We propose a novel power capping module in the Hadoop scheduler to mitigate power peaks. Extensive simulation studies show that our proposed solution can effectively smooth the power consumption curve and mitigate temporary power peaks for Hadoop clusters.     

人工培植冬虫夏草水提物抗人巨细胞病毒的研究

研究人工培植冬虫夏草水提物对人类巨细胞病毒(HCMV)的抑制作用,并对其抑制机制进行初步研究.通过细胞病变法(CPE)检测虫草水提物的细胞毒性及抗病毒活性,同时采用免疫印迹实验(Western Blotting)初步探究虫草水提物抗HCMV的作用靶点.结果表明虫草水提物浓度在0.3 g·L-1以上时能有效抑制HCMV在...     

Ⅰ－Ⅱ复合型裂纹亚临界扩展研究

对两种工程材料ＬＹ１２－ＣＺ铝合金和１６Ｍｎ钢的薄板斜拉伸试件进行了裂纹扩展试验研究。提出了用当量裂纹法预测Ⅰ－Ⅱ复合型裂纹亚临界扩展寿命的方法。实验结果表明，当量裂纹法预测复合型裂纹疲劳寿命的方法简单可行。     

矿用圆环链的初步应力分析

推导出了圆环链在受拉载荷作用下接触处的接触应力计算公式，并利用有限元法计算了结构的应力分布。     

鸟粪石法同步回收发酵液中高质量浓度氮磷

以剩余污泥碱性发酵液为研究对象,考察鸟粪石沉淀法(MAP法)同时回收氮磷的最佳条件及对发酵液中有机物的影响.正交试验结果表明,分别以氨氮(NH4+—N)和正磷酸盐(PO43-—P)回收率为考察标准,四个环境因素的显著性分别依次为:nP∶nN>pH>反应时间>nMg∶nP、pH>nMg∶nP>nP∶nN>反应时间.各个环境因素的优化分析结果表明,最佳的回收条件为:pH=10.0、nMg∶nP=1.8、nP∶nN=1.6、反应时间为5 min,此时NH4+—N和的PO43-—P回收率分别为62.3%和94.1%,同时发酵液中的有机物随着鸟粪石沉淀的析出也略有减少.     

多模式驱动的机器人关节控制器设计及实验

建立了基于直流电机的系统模型,提出了基于PID的闭环反馈控制策略和基于时间或电流的切换控制方法.然后,借助Matlab/Simulink软件分别进行了位置控制、力矩控制及二者切换的仿真,并进行了关节驱动控制系统的软硬件设计.最后,通过实验对所提方法进行了验证与分析.仿真和实验结果表明:所设计的关节控制器,能够实现位置控制、力矩控制功能.在位置控制模式下,影响其响应速度的因素主要是驱动系统硬件.在力矩控制模式下,影响其响应速度的因素主要是PID参数,且当PID参数Kp,Ki,Kd分别为0.2,0.325,3.0时,系统具有较好的响应特性.位置控制与力矩控制2种模式间可基于时间和电流进行稳定的切换.该关节控制器能够应用于机器人关节驱动系统,实现关节的驱动与灵活的控制.     

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Although cancer arises from a combination of mutations in oncogenes and tumour suppressor genes, the extent to which tumour suppressor gene loss is required for maintaining established tumours is poorly understood. p53 is an important tumour suppressor that acts to restrict proliferation in response to DNA damage or deregulation of mitogenic oncogenes, by leading to the induction of various cell cycle checkpoints, apoptosis or cellular senescence. Consequently, p53 mutations increase cell proliferation and survival, and in some settings promote genomic instability and resistance to certain chemotherapies. To determine the consequences of reactivating the p53 pathway in tumours, we used RNA interference (RNAi) to conditionally regulate endogenous p53 expression in a mosaic mouse model of liver carcinoma. We show that even brief reactivation of endogenous p53 in p53-deficient tumours can produce complete tumour regressions. The primary response to p53 was not apoptosis, but instead involved the induction of a cellular senescence program that was associated with differentiation and the upregulation of inflammatory cytokines. This program, although producing only cell cycle arrest in vitro, also triggered an innate immune response that targeted the tumour cells in vivo, thereby contributing to tumour clearance. Our study indicates that p53 loss can be required for the maintenance of aggressive carcinomas, and illustrates how the cellular senescence program can act together with the innate immune system to potently limit tumour growth.