纳米银在小鼠体内的组织分布

将分散在生理盐水中的纳米银以尾静脉注射的方式注入小鼠体内,采用电感耦合等离子质谱(ICP-MS)法检测其在小鼠体内的组织分布情况,并利用DAS药物动力学软件分析其在血液中的动力学参数.实验结果显示:纳米银经尾静脉注射进入小鼠体内后,血液中的w(Ag)在染毒1 h内呈快速下降趋势,其后的24 h内w(Ag)处于平稳状态;纳米银在体内的消除半衰期为22.8 h,分布容积为26.8 L/kg;进入体内的纳米银可随血液循环快速分布到全身各脏器,6 h后即可在小鼠的多个主要脏器中检测到银的存在,其中脾脏中的w(Ag)约为203μg/g;滞留在体内的银主要分布在肝脏和脾脏中.由此可见,纳米银具有较高的组织亲和力,肝脏和脾脏可能是纳米银的主要蓄积作用靶器官.     

面向钢铁制造流程的合同计划组合优化

从钢厂整体流程的层次上研究了合同计划优化问题.首先在分析某钢厂生产流程特点的基础上讨论了铁钢界面、精炼设备和铸轧界面的生产组织,研究了铁水供求节奏的协调.提出了表征铁钢界面铁水供求节奏协调程度的δ因子,并讨论了δ不同取值范围与铁水包备包和等待数目的关系.之后,建立了面向钢铁制造流程的合同计划优化数学模型,并采用禁忌搜索算法对模型进行求解.最后,从钢厂中随机选取3组不同规模的实际生产合同,并对其进行合同计划优化仿真实验.实验结果表明,所建立的合同计划优化模型和求解算法能够较好地解决面向钢铁制造流程的合同计划优化问题.     

采用Petri网的业务性能分析方法

在业务管理系统中,针对业务性能分析过程缺乏自动化的问题,提出一种采用Petri网的业务性能分析方法.该方法通过改进传统Petri网模型,提出业务性能分析Petri网模型;基于该模型设计业务性能计算公式进行自动业务性能计算;采用特定样本训练业务性能分析Petri网模型参数,提高模型参数的准确性.实例分析结果表明,该方法能够建立有效的业务性能分析模型,实现业务性能自动计算和业务性能瓶颈自动发现,且能够通过样本训练提高模型参数的准确性.     

基于消极空间改造的商业步行街景观要素分析——以广州市上下九步行街为例

介绍关于商业步行街景观要素空间理论相关知识,从形成商业步行街消极空间的景观要素入手,探讨如何将消极因素改造为积极要素并防止形成消极空间.结合广州市上下九步行街进行实地考察,并提出针对性改造措施,希望通过该案例的改造建议对我国商业步行街景观空间改造与建设提供有益的参考.     

一种低噪声高PSRR的LDO线性稳压器

介绍了 LDO线性稳压器的系统组成原理,分析了系统的电源电压抑制比(PSRR)以及噪声与电路结构的关系,在此基础上,对LDO的核心电路模块进行了设计,并基于0.5μm标准CMOS工艺,运用Cadence平台进行了模拟仿真和验证.测试结果表明:该LDO的PSRR最低约为-45 dB@1 MHz,最高约为-75 dB@217 Hz;输出电压噪声在10 Hz频率以下约为0.78 μV(P-P),在10 Hz至l00 kHz频率范围内约为0.1 μV(RMS),能满足低噪声和高PSRR应用的要求.     

正弦波脉冲MIG焊铝的正弦振幅参数调控

基于正弦波形的永恒周期性和无限阶导数连续性,结合铝合金类轻质材料焊接时仅需要较低焊接能量等特点,建立了正弦波调制脉冲MIG焊铝正弦振幅参数的简化关系式,通过试验验证了所建立的参数简化关系式的正确性和实用性,应用时易于稳定获得理想的鱼鳞纹焊缝.该简化关系式中振幅系数κ的数值范围在[15.0%,23.1%]时,正弦波调制脉冲焊接具有参数值匹配区间宽、要求低,稳定工作点区域大,受外部环境干扰小等优点.所建立的简化关系式为脉冲MIG焊铝过程中各焊接参数的优化匹配奠定了理论和试验基础.     

不同温度热解酸化蔗糖制备低聚焦糖

为拓展热解酸化蔗糖制备低聚焦糖的应用领域,分别考察了不同温度下干法与湿法制备的低聚焦糖的pH值、特征吸收、褐变程度、糖含量、抗氧化性,并分析了低聚焦糖的主要成分和热稳定性.结果表明:随着温度升高,干法工艺制备的低聚焦糖的pH值先升高后缓慢降低,湿法工艺制备的则逐渐降低;干法工艺制备的低聚焦糖的特征吸收及褐变程度均上升,湿法工艺制备时则在160℃达到最强,分别为3.151和2.128;两种工艺制备的低聚焦糖的总糖含量逐渐减少,还原糖含量先上升后下降,抗氧化性增强;低聚焦糖主要成分为蔗糖、蔗果三糖等低聚糖,以及少量的葡萄糖、果糖等;低聚焦糖的热裂解产物主要有呋喃、呋喃酮、吡唑、吡咯烷、醛、烯和酸酐类.     

Ionic liquids containing the urea moiety for recognition of halides and complex anions

A series of novel imidazolium based ionic liquids containing the urea moiety were designed and synthesized for anion recognition. 1-Ethylurea-3-methylimidazolium acetate ([Eumim]OAc) was used as the receptor for the halides and complex anions (BF4-, PF6-, BPh4-). 1H NMR spectra showed that the urea protons and imidazolium C(2) proton of the receptor ([Eumim]OAc) moved upfield on addition of various anions. A Job plot showed that the [Eumim]OAc receptor formed a 1:1 complex with BPh4-. X-ray diffraction analysis and the molecular modeling study revealed that the conformations of [Eumim]OAc and [Eumim]BPh4 were different. The conformational change of the cation was caused by anion exchange, and may provide an alternative to current methods for recognition of anions.     

Preparation and cytocompatibility of polylactic acid/hydroxyapatite/graphene oxide nanocomposite fibrous membrane

A series of polylactic acid (PLA) based nanocomposite fibrous membranes,including neat PLA,PLA/hydroxyapatite (HA) and PLA/HA/graphene oxide (GO),were fabricated via electrospinning method.The morphology and composition were investigated by scanning electron microscopy (SEM),X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) respectively.The thermal stability was determined by thermogravimetric analysis (TGA).To estimate the cytocompatibility of asprepared PLA/HA/GO fibrous membrane,MC3T3-E1 cells were cultured,and the corresponding cell adhesion and differentiation capability were investigated by fluorescence microscopy,SEM and MTT test.The electrospun ternary PLA/HA/GO membrane exhibited three-dimensional fibrous structure with relatively rough surface morphology,which made itself ideal for cell attachment and proliferation in bone tissue regeneration.The fluorescence microscopy,SEM and MTT test confirmed that the PLA/HA/GO nanocomposite fibrous membrane created a proper environment for the seeding and proliferation of MC3T3-E1 cells.     

Deposition of bio-mimicking graphene sheets with lotus leaf-like and cell-like structures on the nickel substrate

Bio-mimicking graphene films,deposited on textured nickel substrates,were synthesized by the following method:replicating the surface textures of the lotus leaf by polymer duplication,fabricating textured nickel substrates by electroplating on the polymer coated with a Au film,preparing bio-mimicking graphene oxide films on the nickel substrates by vacuum filtration,and electrochemical reduction.By controlling the vacuum filtration,this replica method can not only replicate the lotus leaf structure by a graphene film,but also can achieve a novel cell-like graphene film.