上海市进一步推进海洋经济发展的若干战略思考

纵观人类社会发展的历史,一个明显的轨迹就是沿着流水的边线,从大江大河的中上游地区走向下游及河口地区,从河口走向海岸带,从海洋走向全球.随着经济的高速增长,陆域资源、能源、空间的压力日益加剧,人类已将经济发展的重心逐渐移向海洋世界.     

上海建设海上人工岛及长江口亚三角洲体系的战略意义

近代上海的崛起,依靠的是地处我国弓箭型江海格局关节点的独特区位优势.在上海发展的历史轨迹中,有三个重要的交汇点:即苏州河与黄浦江、黄浦江与长江、长江与东海的汇合处.在第一个交汇点上,形成了以外滩为标志的近代繁华;在第二个交汇点处,包括宝钢、外高桥以及浦东新区,带动了上海改革开放30年的蓬勃发展;而第三个交汇点,就是浩瀚的长江口.     

加强合同管理,增强索赔意识,提高经济效益

文章通过施工实践中的几个索赔事件的处理,介绍了合同管理对施工企业的重要性,施工过程中3个阶段的合同管理及索赔的步骤。     

地震人为灾害的危害性及其预防措施

地震灾害不仅仅是一种单纯的自然灾害,而是自然作用与人类行为共同引起的综合致灾过程,地震时人们错误的应变行为是引起非地震人员伤亡的主要因素.文章阐述了地震人为灾害的概念,通过丰富的震害资料说明人为灾害的危害性,分析了产生人为灾害的原因,并提出了相应的预防对策.     

基于B/S结构的流动地震前兆数据库查询系统的开发与实现

文章介绍了广泛应用于信息网络中B/S服务方式,应用于我中心的流动地震前兆数据库查询系统的开发过程,描述了该方式的应用过程。该系统借助Internet/Intranet网络,以Microsoft ASP为开发语言,用SQL-SERVER数据库建库,采用IIS6.0集成平台开发,使之具有系统加密、数据查询、数据备份、数据上传、数据格式转换和资料下载等功能。     

Genome sequence and analysis of the tuber crop potato

Potato (Solanum tuberosum L.) is the world's most important non-grain food crop and is central to global food security. It is clonally propagated, highly heterozygous, autotetraploid, and suffers acute inbreeding depression. Here we use a homozygous doubled-monoploid potato clone to sequence and assemble 86% of the 844-megabase genome. We predict 39,031 protein-coding genes and present evidence for at least two genome duplication events indicative of a palaeopolyploid origin. As the first genome sequence of an asterid, the potato genome reveals 2,642 genes specific to this large angiosperm clade. We also sequenced a heterozygous diploid clone and show that gene presence/absence variants and other potentially deleterious mutations occur frequently and are a likely cause of inbreeding depression. Gene family expansion, tissue-specific expression and recruitment of genes to new pathways contributed to the evolution of tuber development. The potato genome sequence provides a platform for genetic improvement of this vital crop.     

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

G protein coupled receptors (GPCRs) exhibit a spectrum of functional behaviours in response to natural and synthetic ligands. Recent crystal structures provide insights into inactive states of several GPCRs. Efforts to obtain an agonist-bound active-state GPCR structure have proven difficult due to the inherent instability of this state in the absence of a G protein. We generated a camelid antibody fragment (nanobody) to the human β(2) adrenergic receptor (β(2)AR) that exhibits G protein-like behaviour, and obtained an agonist-bound, active-state crystal structure of the receptor-nanobody complex. Comparison with the inactive β(2)AR structure reveals subtle changes in the binding pocket; however, these small changes are associated with an 11?? outward movement of the cytoplasmic end of transmembrane segment 6, and rearrangements of transmembrane segments 5 and 7 that are remarkably similar to those observed in opsin, an active form of rhodopsin. This structure provides insights into the process of agonist binding and activation.