Coilin levels and modifications influence artificial reporter splicing

Cajal bodies (CBs) and Gems are nuclear domains that contain factors responsible for spliceosomal small nuclear ribonucleoprotein (snRNP) biogenesis. The marker protein for CBs is coilin. In addition to snRNPs, coilin and other factors, canonical CBs contain the survivor of motor neuron protein (SMN). SMN can also localize to Gems. Considering the important role that coilin plays in the formation and composition of CBs, we tested the splicing efficiency of several cell lines that vary in regards to coilin level and modification using an artificial reporter substrate. We found that cells with both hypomethylated coilin and Gems are more efficient at reporter splicing compared to cells in which SMN localizes to CBs. In contrast, coilin reduction, which induces Gem formation, decreases cell proliferation and artificial reporter splicing. These findings demonstrate that coilin modifications or levels impact artificial reporter splicing, possibly by influencing snRNP biogenesis. Received 26 December 2007; received after revision 5 February 2008; accepted 7 February 2008     

Strong association of de novo copy number mutations with sporadic schizophrenia

Schizophrenia is an etiologically heterogeneous psychiatric disease, which exists in familial and nonfamilial (sporadic) forms. Here, we examine the possibility that rare de novo copy number (CN) mutations with relatively high penetrance contribute to the genetic component of schizophrenia. We carried out a whole-genome scan and implemented a number of steps for finding and confirming CN mutations. Confirmed de novo mutations were significantly associated with schizophrenia (P = 0.00078) and were collectively approximately 8 times more frequent in sporadic (but not familial) cases with schizophrenia than in unaffected controls. In comparison, rare inherited CN mutations were only modestly enriched in sporadic cases. Our results suggest that rare de novo germline mutations contribute to schizophrenia vulnerability in sporadic cases and that rare genetic lesions at many different loci can account, at least in part, for the genetic heterogeneity of this disease.     

求解电大目标散射问题的累进迭代方法

在矩量法(MOM)的基础上,采用混合场积分方程(CFIE)结合累进迭代的数值方法(PNM)研究了电大尺寸目标电磁散射问题。目标被分成一些小区域,因此缩小了所需要求逆的矩阵的大小并且减少了计算时间。数值模拟计算了理想导电的圆柱,矩形柱的表面电流分布。所得的结果和一般分域基矩量法的结果以及圆柱的理论计算结果吻合得很好ss,说明了本文方法的有效性。     

基于Multi-Agent系统的预测支持系统的结构

Agent技术是人工智能和计算机科学领域内新兴的研究热点,自治Agent和多Agent系统为复杂软件系统的分析、设计和实现提供了新的思路.给出一种基于Multi-Agent系统的预测支持系统的结构,将系统设计成由多个Agent组成的多Agent系统.各个Agent有自己的功能,可以独立自主地运行,还可以协同工作完成系统整体目标.     

一种脉冲压缩信号旁瓣抑制方法

给出了一种在脉冲压缩技术中实现低的压缩脉冲距离旁瓣的方法,由希望的压缩脉冲波形来设计加权滤波器。导出了可实现低的压缩脉冲距离旁瓣的条件。实验用声表面波(SAW)器件实现时,对线性调频信号,其压缩脉冲最大主旁瓣比为50dB。而用数字方法实现时,压缩脉冲最大旁瓣电平还受A/D及D/A变换器位数的限制。     

随机需求下基于库存责任期的装配系统准时供货模型

以装配系统为研究对象, 考虑在VMI模式下, 当制造商采取设定库存责任期以抵御市场需求时间不确定的风险时, 供应商的最优供货时间决策和制造商最优的库存责任期设置. 文章分别建立了单供应商对单制造商和多供应商对单制造商的主从博弈准时供货模型, 通过数学证明和遍历算法找到了供应链双方在不同模式下的最优选择. 研究结果证明制造商并 不应该选择过长的库存责任期, 而供应商之间的不同步供货会对供应链整体造成巨大损失. 并且通过对比集中与分散决策下的供应链绩效, 给出实现系统协同的必要条件. 最后通过算例分析进一步证明相关结论.     

利他、公平和信任等因素对合作的影响

分析了利他、公平、信任等因素对博弈过程中合作的影响,以典型的"gift-exchange博弈模型"为例,假设博弈方行为受到一些因素影响并且可以用启发式规则简单描述,通过对成员Agent内部的利他、公平、信任等属性和交互过程中启发式规则的设计和编程实现,使得博弈双方在博弈过程中不断学习和调整策略,形成最终达成一致的合作机制.利用多Agent系统平台--JADE对所提出的模型进行仿真,通过对实验数据的分析,揭示了在多Agent系统中利他、公平以及信任等因素对合作的影响,指出了这些因素在经济生活中的实际指导意义.     

Turbo／MAP编译码器中的交织器优化设计

讨论采用软输出迭代译交织级联卷积码（Ｔｕｒｂｏ码）编译码器中的交织器优化设计问题．从基于最大后验概率（ＭＡＰ）算法与迭代译码的Ｔｕｒｂｏ码编译码原理出发,给出交织器设计的一些基本方法并分析其特点;提出“保奇偶”的随机交织器设计方案,它能有效地改善某些以提高编码效率为目的的“删余截短”Ｔｕｒｂｏ码的纠错性能．通过计算机仿真得出一些Ｔｕｒｂｏ码在加性高斯白噪声信道中采用不同交织器时的误码率数据,分析了交织类型和交织深度的变化对Ｔｕｒｂｏ码纠错性能的影响．针对Ｔｕｒｂｏ码的特点提出了在卫星通信等应用中交织器设计的实用性结论．