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11.
BaiYang Sheng Ying Niu Hui Zhou JiaXin Yan NanMing Zhao XiuFang Zhang YanDao Gong 《科学通报(英文版)》2009,54(10):1725-1731
The amyloid precursor protein (APP) is recognized as the source of Aβ, which plays an important role in Alzheimer’s disease. However, the biological function of APP is obscure. Previous studies showed that mitochondria could be a target of APP. In this work, APP knockout mouse embryo fibroblast (MEF) cells were used to test if APP plays any role in maintaining the mitochondrial function. As the result, APP knockout MEF cells (APP-/- cells) showed the abnormal mitochondrial function, including slower cell pr... 相似文献