Molecular genetic basis for the rhino mouse from Chinese KM subcolony

Both the rhino mouse and hairless mouse resulted from hairless gene mutation, but they show different phenotypes of skin physiology. The rhino mouse has more similar histological characters to human papular alopecia.Therefore rhino mouse is a good experimental animal model for human papular alopecia. This study reports a hairless mouse named rhino KIZ, arose from KM colony in Kunming Institue of Zoology, by systematic studies on morphology,skin histopathology, gene sequence, pedigree and protein domain analysis. The results demonstrate that a C-to-T transition in exon 11 of hr gene (The mutant gene has been applied for a Chinese patent (patent No. 03135280)) results in the rhino KIZ. The rhino KIZ with clear genetic mechanism will be a useful animal model.     

Ti(C,N)基金属陶瓷烧结性能及其组织的研究

研究了温度与碳含量对Ｔｉ（Ｃ，Ｎ）基金属陶瓷烧结性能及组织的影响，研究结果表明：材料的抗弯强度对烧结温度最敏感，而密度、硬度、平均线收缩系数对烧结温度的敏感性依次递减；材料中碳粉含量增加时，会使其烧结温度明显降低，当添加量为２．２％时，金属陶瓷组织中会出现石墨相，使材料的抗弯强度下降．     

氩气热力学参数和输运系数的分子动力学模拟

运用一维分子动力学模拟的方法计算了由氩气分子组成系统的热力学参数和输运系数，并与相应的三维分子动力学模拟的结果及实验数据进行了比较，发现运用一维分子动力学模拟能够得到比较接近宏观真实系统的某些物理性质，并减少计算时间。该方法能够模拟计算分子数目更多的系统。因此，对所研究系统的某些物理性质来说，一维分子动力学模拟是一种有效的分子模拟方法。     

Dynamic response characteristic of 7N01/7A01/7050 aluminium multilayer plate at high strain rate

The correlations between the structures,fracture behavior and dynamic shear property were investigated for 7050 to 7 N01 layer of 7 N01/7 A01/7050 multilayer plate with different thickness ratio fabricated by hot rolling bonding.is The results showed that when thickness ratio of 7050 to 7 N01 layer was 1 and 7050 layer was backplane,the absorbed energy of the multilayer plate was 39% higher than that of 7050 alloy.The excellent energy absorbing ability of 7 N01/7 A01/7050 multilayer plate is att...     

三维曲面的激光精密加工

介绍了采用激光打孔技术加工复杂曲面的方法，同时利用ＩＢＭ３８６机组建了ＣＡＤ和ＣＡＭ一体化的柔性加工系统。     

试论清末高教体制的草创与运行

运用机制理论,对清末高教改革在新旧高教体制转换中的近代化意义、所引起的深刻变化及其内在矛盾作了分析,认为清末在高教改革开放方面的首次尝试,不仅建构了现代高等教育的基本框架,而且给后人留下了宝贵的历史启示。     

基于小波包散布熵与Meanshift概率 密度估计的轴承故障识别方法研究

为提升轴承故障特征提取精度和运行状态评估准确性,提出一种基于小波包散布熵与Meanshift概率密度估计的诊断方法.首先,采用小波包变换对轴承振动信号数据进行升维,通过计算每个子带的散布熵构建特征矩阵;然后,利用PCA对多维矩阵进行可视化降维,采用Meanshift无参估计得到训练样本的概率密度最大位置作为聚类中心;最后,通过计算测试样本散布熵坐标与各聚类中心的欧式距离判定测试样本类别归属.采用CWRU和QPZZ-II轴承实验台不同故障类型和故障程度样本数据对所提方法进行验证,结果表明,得益于小波包完备的理论模型和信号频带分解稀疏性,结合散布熵指标对数据样本良好的鲁棒性,所构造的特征矩阵具有较好的类内聚集性和较大的类间距离,同时,Meanshift以概率密度最大化为目标自适应迭代聚类中心和隶属度,可以有效实现对不同数据样本的分类识别.     

多层砾石充填完井压力评价

针对多层砾石充填完井的渗流特点,将每个产层在径向方向上分成3个区域,即砾石充填区、射孔区、地层径向流区,每个区域有各自的渗流方程,对n层油藏将有3n个渗流方程,对砾石充填区采用边界元,对射孔区采用有限元,对地层径向流区采用半解析半数值解,最终得到各区域的压力损失及表皮系数,以及井底压力及分层产量与时间的变化关系.     

Stretching and imaging studies of single DNA molecules

DNA molecules were stretched on silanized mica surface with the molecular combing technique, and detected with fluorescence microscopy and atomic force microscopy. Meantime, DNA molecules were stretched with a modified dynamic molecular combing technique and studied with atomic force microscopy. The results indicate that, compared with the dynamic molecular combing technique, the modified dynamic molecular combing technique has advantages of less-sample demand and less contamination to sample; as compared with the molecular combing technique, it has better aligning effect and reproducibility. Combination of this kind of DNA molecular manipulating technique with the single DNA molecule detecting technique by atomic force microscopy and fluorescence microscopy will play an important role in the basic research of molecular dynamics and the application of gene research.     

HAsO_2在金电极上的阴极还原行为

采用环盘电极实验和交流阻抗技术等研究了ＨＡｓＱ_２在硫酸钠溶液（ｐＨ＝４．０）中在金电极上的阴极还原行为．结果表明,ＨＡｓＯ_２可以最终还原为 ＡｓＨ_３．整个还原过程可以分为两步：ＨＡｓＱ_２还原为金属Ａｓ和金属Ａｓ进一步还原成ＡｓＨ_３,还原产物ＡｓＨ_３在电极上的吸附较强,溶出性能较差．这两步还原过程在阻抗的复数平面图上呈现二个明显的电容弧,利用 ＥＱＵＩＶＣＲＴ软件对其进行计算机拟合,得到了对应的等效电路以及其中的反应电阻元件的数值．