The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier.     

环境规制政策与公共健康——基于环境污染的中介效应检验

为了探究环境规制政策对于环境污染及公共健康的影响,本文基于我国1978至2013年颁布的976条环境规制政策,利用从政策属性力度、政策内容力度两个维度对我国环境规制政策进行量化的数据,构建了针对环境规制政策效果的计量模型,通过将中介效应检验方法引入环境健康经济学分析,检验了环境污染对环境规制政策与公共健康的中介效应.研究结果表明:环境规制政策对公共健康具有促进作用;我国总体的环境规制政策对于防治环境污染产生了一定程度的积极效果;环境规制政策通过对环境污染显著的部分中介效应进而对公共健康产生了促进作用.本研究基于总体环境规制政策文献量化角度考察的"政策-环境-健康"三维动态关系结果,阐明了环境规制政策、环境污染以及公共健康三者的影响传输路径,对于有效评估环境规制政策效果,保障环境质量以及公共健康的可持续提升具有理论借鉴价值.     

黄冈公铁两用长江大桥维修通道施工

维修通道专为桥梁竣工后接收管养单位而设。本文以黄冈桥维修通道为例,从下部基础到上部主体框架乃至附属,全面地叙述了各部位的施工情况及工序控制要点,为以后类似施工提供一定经验。     

Reconsideration on Homogeneous Quadratic Riemann Boundary Value Problem

The homogeneous quadratic Riemann boundary value problem (1) with Hoelder continuous coefficients for the normal case was considered by the author in 1997. But the solutions obtained there are incomplete. Here its general method of solution is obtained.     

一种有效的网格综合优化算法

提出一种有效的网格综合优化算法。给定一定数量的三维散乱点和一个初始三角网格,使用Hoppe提出的能量函数对网格顶点位置优化,使网格更好的逼近三维散乱点。同时通过分裂网格中度数特别大的节点,使网格的空间形状更加平滑。计算机仿真实验表明,使用该算法能够获得形状良好的网格。     

New Develoopment of the Basic Theory of Extenics

In this paper,the new development of three basic theories of Extenics,incluing basic-element theory,extension set theory and extension logic theory ,has been introduced.And the new theoretical frame of Extenics has also been set forth.     

高考走向的争鸣与思考

高考走向何方,成为人们热议的话题。有人主张废除高考,有人反对废除,主张改革;有人赞成统一高考,有人赞成高校单独招考……笔者认为高考要改不宜废,但改革要考虑国情,要遵循一定原则,要有比较稳定的思路,要有灵活应变的策略和科学的方法。     

Abrupt climate change：Debate or action

Global abrupt climate changes have been documented by various climate records, including ice cores, ocean sediment cores, lake sediment cores, cave deposits, loess deposits and pollen records. The climate system prefers to be in one of two stable states, i.e. interstadial or stadial conditions, but not in between. The transition between two states has an abrupt character. Abrupt climate changes are, in general, synchronous in the northern hemisphere and tropical regions. The timescale for abrupt climate changes can be as short as a decade. As the impacts may be potentially serious, we need to take actions such as reducing CO2 emissions to the atmosphere.     

The Optimal Solution of the Model with Physical and Human Capital Adjustment Costs

We prove that the model with physical and human capital adjustment costs has optimal solution when the production function is increasing return and the structure of vetor fields of the model changes substantially when the prodution function from decreasing return turns to increasing return. And it is shown that the economy is improved when the coefficients of adjustment costs become small.     

基于B/S模式的水利水电工程造价管理系统研究

提出了基于B／S模式的水利水电工程造价管理系统，对B／S的体系结构、系统的总体结构设计、功能及功能设计进行了阐述，并说明了系统实现的关键技术．