Short alanine-based peptides may form 3(10)-helices and not alpha-helices in aqueous solution.

Short alanine peptides, containing 16 or 17 residues, appear to form alpha-helices in aqueous solution. But the main spectroscopic analyses used on helical peptides (circular dichroism and nuclear magnetic resonance) cannot distinguish between an alpha-helix (in which the ith residue is hydrogen-bonded to residue i + 4; ref. 9) and the next most common peptide helix, the 3(10)-helix10 (i-->i + 3 hydrogen-bonding). To address this problem we have designed single and doubly spin-labelled analogues of alanine-based peptides in which the nitroxide spin label forms an unbranched side chain extending from the sulphur atom of a cysteine residue. Here we report the circular dichroism, Fourier-transform infrared and electron-spin resonance spectra of these peptides under helix-forming conditions. The infrared absorbance gives an amide I' band with a frequency that is substantially different from that observed for alpha-helices. The electron-spin resonance spectra of doubly labelled helices show that the ranking of distances between side chains, around a single turn (residues 4-8), is inconsistent with an alpha-helical structure. Our experiments suggest that the more likely peptide geometry is a 3(10)-helix.     

狄拉克（Dirac）与当代物理学

从量子力学、真空、大数假说、磁单极子诸方面，阐述了坎拉克的治学思想和研究方法的特点及其对当代物理学所做出的重大贡献．     

灭滴灵治疗智齿冠周炎的临床观察

本文对１０００例智齿冠周炎的患者采用三种治疗方法．其中一种单独给予口服灭滴灵，一种给予肌注青霉素．另一种则采用灭滴灵十肌注青霉素治疗．结果显示：三种治疗方法的疗效无显著差异．而灭滴灵有口服方便，安全，副作用少之优点．     

否定毛细永动机的唯象理论

本文从毛细现象自身所满足的规律、弯曲液面所具有的性质着手，给出了一种否定毛细永动机的唯象理论。     

高新技术开发区网络管理系统的设计

根据高新技术产业开发区的特点，提出了一系列有针对性的软、硬件设计。     

Statecharts for Distributed Product Data Management System Modelling

Product data management (PDM) has been accepted as an important tool for the manufacturing industries. In recent years, more and mor e researches have been conducted in the development of PDM. Their research area s include system design, integration of object-oriented technology, data distri bution, collaborative and distributed manufacturing working environment, secur ity, and web-based integration. However, there are limitations on their rese arches. In particular, they cannot cater for PDM in dis...     

论害虫综合治理(IPM)中的容忍哲学

“容忍哲学”是 IPM 理论最具特色的基本概念,是害虫防治策略上的重大观念更新。从“消灭哲学”到“容忍哲学”的转变,是害虫防治策略上质的飞跃,是几千年害虫防治实践的历史必然;是生态学观点应用于害虫防治的必然;并且有着深刻的科学背景。“容忍哲学”的基本含义可以概括为:害虫综合治理是生态系统功能的一种整合作用。容忍无损大局;容忍有利于自然控制因子发挥作用;容忍有利于保护环境;容忍并不完全排斥消灭。     

Chromosomal effects of adeno-associated virus vector integration.

Adeno-associated virus (AAV) vectors are currently being used in several clinical gene-therapy trials (see the NIH OBA Human Gene Transfer Clinical Trials Database); however, little is known about the chromosomal effects of vector integration. Here we report that integrated vector proviruses are associated with chromosomal deletions and other rearrangements and are frequently located on chromosome 19 (although not at the wildtype AAV integration site).     

Decision trees for forecasting

Recent years have seen an increasing cross-fertilization between the fields of decision analysis and forecasting. Decision-analytic models often require forecasts as inputs, and aspects of the Bayesian decision-theoretic framework underlying decision analysis have proved useful to forecasting, particularly in contexts where subjective judgemental inputs are required. This paper describes the use of decision tree analysis for forecasting and illustrates its use for corporate divisional forecasting and planning. A specialized decision-analytic technique, acts as events, is also described and illustrated to forecast a new product's earnings. Conclusions are drawn about the applicability of decision analysis for forecasting.     

Indoxyl derivatives of drug metabolites

Summary Indoxyl derivatives were detected as minor products among the urinary metabolites of two trial drugs, a benzodiazepine (GP 55 129) and a benzophenone (CGP 11 952). Their structures were elucidated by NMR and mass spectroscopy. Presumably, metabolites containing potential aldehyde functions react spontaneously with endogenous indoxyl. Such derivatives have not hitherto been encountered in drug metabolism.