Inducing dopaminergic differentiation of expanded rat mesencephalic neural stem cells by ascorbic acid in vitro

Ascorbic acid (AA) induced differentiation of neural stem cells (NSCs) into dopaminergic (DAergic) neurons is reported.NSCs derived from rat mesencephalon were maintained and expanded in a defined medium containing mitogens of basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF).Compared with the control, ascorbic acid treatment led to more DAergic neuronal differentiation as indicated by the expression of tyrosine hydroxylase (TH) and dopamine transporter (DAT), which are specific markers of dopamine neurons.AA induction also enhanced expression of Nurr1 and Shh.PD98059, an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway, could block AA-induced Nurr1, TH and DAT mRNA expression.The results might suggest a new strategy to provide enough dopaminergic cells for the therapy of Parkinson's disease (PD), and Nurr1 and ERK signaling pathway might participate in the AA-induced DAergic differentiation.     

An improved form of the ELMS algorithm

1.INTRODUCTION Adaptiveechocancellersarewidelyemployedintele conferencingsystemsinordertocompensateforthe impairmentinthequalityduotoundesiredechoesre sultingfromcouplingbetweenloudspeakerandmicro phone.Inastereophonicenvironment,thefunda mentalproblemofechocancellationisthatgiventhe inputtotheloudspeakersandtheoutputofthemicro phonesinthereceivingroom,theechopathcannot bedetermineduniquely[3,8,9].Theproblemisdueto thecorrelationbetweenthestereosignals.Asare sult,anyadaptivetechniqueusedi…     

SCIAA教学法--基于"学生本位课程"的英语精读教学法

“学生本位课程”是以人本主义心理学和建构主义课程观为基础的一种新型课程。这种课程确立了学生在教学中的主体地位以及教师的主导作用，强调在教学中充分利用学生原有知识和经验。SCIAA教学法是笔者将“学生本位课程”应用于教学实践而形成的一种新的英语精读教学方法。     

The Intelligent Decision Support System Model of SARS

Based on the intelligent decision support system, a new method was presented to defense the catastrophic infectious disease such as SARS, Bird Flu, etc.. By using All Set theory, the decision support system (DSS) model can be built to analyze the noise information and forecast the trend of the catastrophe then to give the method or policy to defend the disease. The model system is composed of four subsystems: the noise analysis subsystem, forecast and simulation subsystem, diagnosis subsystem and second recovery subsystem. They are discussed briefly in this paper. This model can be used not only for SARS but also for other paroxysmal accidences.     

直纹曲面喷漆机器人喷枪轨迹多目标优化

针对直纹曲面上喷漆机器人的喷枪轨迹多目标优化问题,通过平面喷漆实验,采集各点膜厚数据,运用MATLAB遗传算法工具箱拟合β分布,建立直纹曲面漆膜厚度生长模型.将曲面离散为点集,采用三次B样条曲线拟合生成初始喷枪轨迹.以曲面上各点漆膜厚度均匀和喷涂效率高为目标建立喷枪轨迹多目标优化模型,并采用改进的快速非支配排序遗传算法对该模型求解,获得喷枪轨迹最优解集,最终实现了直纹曲面喷枪轨迹的优化目标.通过实例结果对比验证了该方法的有效性和实用性.     

Primary Sn-rich titianite in the Qitianling granite, Hunan Province, southern China: An important type of tin-bearing mineral and its implications for tin exploration

The Qitianling calc-alkaline granite in Hunan Province (South China) has attracted much attention since the discovery of the Furong super-large tin deposit. The present study provides new mineralogical data to address their implications for exploration of tin deposits. In the Taoxiwo granite in the southeastern part of the Qitianling granite body, Sn-rich titanite was identified as an important type of Sn-bearing mineral. The titanite commonly occurs with biotite as euhedral crystals, exhibiting typical envelope-like shape and sector-zoning texture. These indicate that the titanite most likely crystallized in the magmatic stage. Electron-microprobe analyses show that the titanite is enriched in tin up to 1.12 wt% SnO₂, with an average of 0.43 wt%. With the crystallization of the granite, primary minerals undertook hydrothermal alteration by magma-derived fluids. Subsequently, in the hydrothermal stage, the primary Sn-bearing titanite was altered (at least partially), but still preserved its typical envelope-shaped outline. Micro-scale cassiterite is a representative product of such alteration; other secondary minerals include fluorite, ilmenite, Sn-bearing rutile and quartz. Therefore, the titanite, commonly present in the calcalkaline granites, can be treated as an important Sn-carrying mineral in the Qitianling granite, reflecting the primary magmatic environment with tin enrichment. The hydrothermal alteration of the primary titanite and subsequent crystallization of cassiterite recorded a process of leaching and accumulation of tin in magmatic-hydrothermal evolution of the Sn-bearing granite. Thus, this titanite has important implications for tin exploration. Supported by National Natural Science Foundation of China (Grant Nos. 40730423 and 40221301) and Project of China Geological Survey (Grant No. 1212010632100)     

砂土的形变能破坏准则

本文基于国内外有关中主应力对砂土抗剪强度影响的模型，讨论了中主应力对砂土抗剪强度的影响机理，导出了以形变能破坏准则为基础，适用于复杂应力条件的强度指标计算公式，较好地考虑了砂性土在三轴压缩与三轴拉伸条件下强度指标的差异和中主应力对强度指标的放大效应。本文公式在考虑粘结应力的情况下，也可推广到对粘性土强度变化的研究。     

DEGDA／HPA厌氧胶配方的优化试验

本文介绍了以一缩二乙二醇丙烯酸双酯(简称一缩双酯,DEGDA)和丙烯酸β-羟丙酯(简称羟丙酯,HPA)为单体,以N,N-二甲基苯胺/糖精为促进剂/助促进剂或仅用三氯乙酸作促进剂来配制厌氧胶粘剂(厌氧胶)的优化配方试验.所得厌氧胶综合性能良好,通过优化试验结果得知的规律性认识有一定意义.     

Na0.5Bi0.5TiO3-BaTiO3无铅压电陶瓷制备及性能

研究了不同烧结制度下的NBBT6陶瓷的致密度、介电和压电性能.870℃左右预烧,可以得到致密且压电和介电性能较好的陶瓷(d33=107 pC/N.∈r=750,tanδ为3.23%).通过相应的粒度分析可知,提高预烧温度对粒度的影响不太大,但可用于湿法制备工艺中的原材料制备,解决湿法工艺中材料易被极性水分子解离而影响材料组分的问题.加入少量的BaTiO3到NBT中形成NBT-BT的固溶体,通过对压电介电性能及XRD的分析可知.当质量分数x=0.06时.(1-x)Na0.5Bi0.5TiO3-xBaTiO3晶体结构出现由三方相到四方相的转变,此时的性能达到最大值(d33=114 pC/N,∈r=1 173.tanδ为3.4%).