Gaining a better understanding of nonhuman primate research

The use of animals in research has long been debated.In partic-ular,the use of nonhuman primates(NHPs)in either basic or applied research is controversial[1,2]....     

Chiglitazar monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes:a randomized,double-blind,phase 3 trial(CMAS)

Chiglitazar(Carfloglitazar)is a novel peroxisome proliferator-activated receptor(PPAR)pan-agonist that has shown promising effects on glycemic control and lipid...     

High content anion (S/Se/P) doping assisted by defect engineering with fast charge transfer kinetics for high-performance sodium ion capacitors

The rate-determining process for sodium storage in TiO2 is greatly depending on charge transfer happen-ing in the electrode materials owing to its inferior diff...     

微生物油脂花生四烯酸产生菌离子束诱变和发酵调控

某些微生物是高质量油脂的生产者.微生物油脂不仅有益健康,而且是生物柴油潜在的油脂来源.中国是个油脂资源缺乏的国家,开发微生物源油脂具有重要的意义.本文以产油微生物——高山被孢霉菌为出发菌,以单细胞油脂多不饱和脂肪酸产率为筛选目标,采用二步离子束诱变-筛选的策略,获得了高产菌株.研究了高产菌株的营养需求,创建了重复利用提油后的残体(菌粕)合成微生物油脂的技术.针对丝状真菌高密度发酵的传能和传质问题,研制了6×50和4×200m3大容量专用反应器组,单位发酵容积生物量达38.2g/L(发酵液)、油脂20.67g/L.其中具有重要生理活性的花生四烯酸产率最高达9.89g/L,平均为8.97g/L.花生四烯酸提取和精炼后的残油转化为生物柴油,主要指标达到国家生物柴油标准.     

珠江三角洲文化形态论纲

珠江三角洲文化形态的性质是务实求利;其特征是商业俗文化;其结构由岭南文化、中原文化、港澳文化和西方文化四因素构成;其地位是有中国特色的社会主义新文化的“曙光”,是中华民族大一统文化的“中介”。     

舟山渔场禁渔线以外海域单拖网渔业主要经济鱼类生物学的初步研究

根据2010年8个半月（除去伏季休渔期）舟山渔场禁渔线以外海域单拖网渔业资源调查资料,分析了7种主要经济鱼类的生物学特征。使用FiSATⅡ软件中ELEFAN技术估算了生长参数、自然死亡系数、总死亡系数和开发率等。结果表明,与历史记录比较鱼类小型化更加明显,总死亡系数增大。其中5种鱼类处于超额开发状态,开发率超过了0.5。目前舟山渔场主要经济鱼类小型化严重,捕捞对鱼类影响较大,须加强对舟山渔场渔业资源的保护。     

机械扰动下风流非稳定流动的数学模型

从流体力学基础理论和矿井风流流动的基本规律出发，推导出了机械扰动下，矿井风网内风流一维非稳定流动的数学模型。为矿井风流非稳定的分析提供了数学基础。     

DNA 标记在种群研究中的应用

DNA标记的出现为种群生物学家解决某些种群问题提供了有用的工具，选择好合适的DNA标记，能揭示出种群发展的基本过程。     

Soluble Jagged 1/Fc chimera protein induces the differentiation and maturation of bone marrow-derived dendritic cells

A soluble Jagged 1/Fc chimera protein （Jagged 1/Fc） was directly used to induce differentiation and maturation of bone marrow-derived dendritic cells （DCs） in mice in vitro. A model of inducing and amplifying DCs in vitrowas established. The effect of Jagged 1/Fc on morphology of DCs induced by both rmGM-CSF and rmlL-4 was observed under a confocal microscope. A fluorescein-labeled monoclonal antibody staining combined with flow cytometry was applied to detect the effect of Jagged 1/Fc on the expression of CD11c, MHC-Ⅱ, CD86, CD80 and CD40 molecules on the surface of DCs. The results showed that Jagged 1/Fc did not affect the morphological properties of DC differentiation induced by both rmGM-CSF and rmlL-4. But it could promote the differentiation and maturation of DCs induced by both. The effect of it was strikingly different in the expression profile of co-stimulating molecules and the morphologic properties of DCs from lipopolysaccharide （LPS）. The levels of MHC-Ⅱ and CD40 molecule expression on the surface of DCs stimulated by Jagged 1/Fc were significantly lower than those stimulated by LPS, and the level of CD80 expression on the surface of DCs induced by Jagged 1/Fc was near to that induced by LPS. Jagged 1/Fc had no influence on the expression of CD86 molecule on the surface of DCs. Jagged 1/Fc when used alone could not maintain the growth, differentiation and maturation of DCs. All the findings indicate that Jagged 1/Fc influences the differentiation and maturation of DCs, which is not markedly similar to LPS, providing important evidence for its development and application as a novel immunosuppressant.     

社交媒体位置数据支持下的城市功能区识别——以上海市为例

基于社交媒体位置数据,采用K-means聚类方法,通过分析在500 m×500 m网格尺度上,城市不同时间的腾讯用户密度热力值变化规律,识别上海城市功能区,将不同区域按功能区类型划分为产业园区、城市居住区、郊区居住区、城市综合功能区、农村村落地区、农田、滩涂及未利用地分布区.通过将识别结果与高分辨率卫星影像和兴趣点（POI）数据的对比分析,证明了使用社交媒体位置数据进行城市功能区识别的可行性.本方法获取数据成本低,运用简便,为对其他地区主体功能区的划分提供了一种新的思路与方法.