容器内壁射流清洗效果的评价与优化

以清洗面图像的平均灰度值为指标,对清洗效果进行评价,从而达到对容器内壁清洗进行研究和分析的目的;以固定式清洗球作为产生射流的基本元件,通过改变流体的压力、清洗的时间、清洗球的位置等方式来研究清洗效果的影响因素,对容器内壁射流清洗的参数进行优化.实验表明:在某一水平高度上,如果要得到较好的清洗效果,清洗球应置于中心位置;清洗球水平居中,变换其竖直位置,置于容器顶部时的清洗效果最好.     

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

Neuropathological hallmarks of Alzheimer's disease are neurofibrillary tangles composed of tau and neuritic plaques comprising amyloid-beta peptides (Abeta) derived from amyloid precursor protein (APP), but their exact relationship remains elusive. Phosphorylation of tau and APP on certain serine or threonine residues preceding proline affects tangle formation and Abeta production in vitro. Phosphorylated Ser/Thr-Pro motifs in peptides can exist in cis or trans conformations, the conversion of which is catalysed by the Pin1 prolyl isomerase. Pin1 has been proposed to regulate protein function by accelerating conformational changes, but such activity has never been visualized and the biological and pathological significance of Pin1 substrate conformations is unknown. Notably, Pin1 is downregulated and/or inhibited by oxidation in Alzheimer's disease neurons, Pin1 knockout causes tauopathy and neurodegeneration, and Pin1 promoter polymorphisms appear to associate with reduced Pin1 levels and increased risk for late-onset Alzheimer's disease. However, the role of Pin1 in APP processing and Abeta production is unknown. Here we show that Pin1 has profound effects on APP processing and Abeta production. We find that Pin1 binds to the phosphorylated Thr 668-Pro motif in APP and accelerates its isomerization by over 1,000-fold, regulating the APP intracellular domain between two conformations, as visualized by NMR. Whereas Pin1 overexpression reduces Abeta secretion from cell cultures, knockout of Pin1 increases its secretion. Pin1 knockout alone or in combination with overexpression of mutant APP in mice increases amyloidogenic APP processing and selectively elevates insoluble Abeta42 (a major toxic species) in brains in an age-dependent manner, with Abeta42 being prominently localized to multivesicular bodies of neurons, as shown in Alzheimer's disease before plaque pathology. Thus, Pin1-catalysed prolyl isomerization is a novel mechanism to regulate APP processing and Abeta production, and its deregulation may link both tangle and plaque pathologies. These findings provide new insight into the pathogenesis and treatment of Alzheimer's disease.     

盾构滚刀磨损的多元非线性回归预测

为了解决硬岩地层盾构滚刀的磨损检测问题,提出了一种基于多元非线性回归预测模型预测滚刀磨损的方法.利用滚刀正常磨损阶段的盾构掘进参数数据建立回归预测模型,根据依此模型预测的掘进速度与实际掘进速度偏差来预测滚刀的磨损状况.结合盾构工程项目研究结果表明:预测模型是正确的,预测结果与实际换刀情况是相符的,预测方法是有效的.研究结论可为类似地质条件下的盾构滚刀磨损检测和更换提供有益的指导.     

二阶非线性模态参数识别方法的研究

提出一个新的非线性模态参数识别的方法──曲面拟合方法．该方法根据 Ｖｏｌｔｅｒｒａ函数级数理论，在识别出非线性系统高阶传递函数的基础上，分析了非线 性高阶传递函数的分布特征，建立一个差频坐标系，对非线性高阶传递函数进行对角 化处理，进而进行整体曲面拟合（ＳＦＭ），实现非线性模态参数的识别。     

龙女寺构造须家河组天然气成藏主控因素

龙女寺构造须家河组天然气藏为较典型的岩性油气藏,其圈闭闭合高度低、储层致密、气水分布关系复杂。分析了须家河组气藏的烃源岩、储集岩、盖层和圈闭条件,认为其成藏条件优越;利用磷灰石裂变径迹技术和Easy%Ro化学动力学模拟技术重建了烃源岩的生烃演化史,结合构造演化再现了须家河组气藏的充注过程,将其分为3 个成藏阶段,中侏罗世末期的油气初次充注期,白垩纪末的大规模充注期和喜马拉雅期的气藏改造和重新定位阶段。指出了须家河组岩性气藏成藏的主控因素：优质烃源岩的发育是物质基础,古今构造均处于油气运移的有利指向区,储集物性和圈闭闭合高度控制了气水的分布,局部裂缝发育带则是成藏及高产的关键因素。     

幂等元满足置换恒等式的半群上的好同余

设Ｓ是幂等元满足置换恒等式的富足半群,则Ｓ是左正规带Ｌ,右正规带Ｒ和适当半群Ｔ的拟织积,记作Ｓ＝ＱＳ（Ｙ,Ｌ,Ｔ,Ｒ）。给定Ｌ上的同余λ,Ｒ上的同余τ,Ｔ上的好同余η,它们满足一定的相容性条件,称（λ,η,τ）是Ｓ的好同余组。对Ｓ的每一个好同余组（λ,η,τ）,定义Ｓ上的关系ρ（λ,η,τ）：（ｅ,ａ,ｆ）,（ｕ,ｂ,ｖ）∈Ｓ,（ｅ,ａ,ｆ）ρ（λ,η,τ）,（ｕ,ｂ,ｖ）＝ｅλｕ,ａηｂ,ｆτｖ     

小波包信号提取算法及其在故障诊断中的应用

提出了提取强噪声背景下多通带窄带信号的一种新方法小波包信号提取算法．这是利用小波包将信号按任意时频分辨率（满足测不准原理）分解到不同频段的特点而提出的．介绍了小波包理论；给出了小波包信号提取算法，并以仿真结果说明了该算法的有效性；以滚动轴承的故障诊断为例，说明该方法可以用于故障诊断和预知维修     

燃煤发电机组灵活运行控制技术研究进展

加快构建新型电力系统是助推“双碳”目标实现的核心关键。风、光可再生能源的大比例接入给电力系统的安全稳定运行带来了新的挑战，对燃煤机组的安全、深度、灵活调峰控制也提出了更高要求。依据煤电机组智能灵活调峰控制技术的发展历程，从被控对象建模和灵活运行控制方法两个层面进行梳理与分析，研究结果表明，辅以机器学习和其他智能系统辨识方法的混合建模方式，以及融合预测控制、自适应控制、多目标智能寻优等先进控制技术更加适合未来煤电机组灵活智能控制的需要，是未来煤电机组灵活、智能控制技术发展的主要方向。