剪切闸板防喷器剪切性能评价

剪切闸板防喷器是井控设备的重要组成部分之一,其作用是在钻井过程中遇到突发情况时及时剪断钻杆并密封井口,其剪切性能直接关系到钻井作业的安全.以某新型上直下V结构的剪切闸板防喷器为研究对象,通过显示动力学模块对剪切闸板剪切钻杆的过程进行数值仿真模拟,分析研究闸板的剪切性能.并用该剪切闸板分别剪切5 in和5.5 in两种不...     

基于数字电视无线广播信号的定位模型和系统

分析了使用数字电视(DTV)无线广播信号定位系统的必要性与可行性.提出了基于帧同步的DTV定位原理.分析了DTV定位测距特性,即在一个历元异步顺序得到多个测距观测值.推导了相关伪距观测模型和载波多普勒积分模型,在此基础上给出了DTV定位模型,包括观测方程和状态方程.仿真结果表明,DTV定位技术能够显著提高独立定位或组合导航系统定位精度.DTV定位是一种具备亚米级测距误差和米级定位精度,可成为传统卫星定位有益补充或替代的定位技术.     

可重构视频阵列处理器测试平台设计与实现

针对可重构视频阵列处理器的设计要求及传统测试方法测试视频编解码系统时速度慢、精度低和可观测性不强的问题。开发了基于Qt的用户界面,设计实现了以现场可编程门阵列(Field programmable gate-array,FPGA)为核心的软硬件协同测试平台。在PC端实现以软件仿真为基础的数据传输与图像重现,在FPGA端实现以可重构视频阵列处理器为基础的视频编解码算法并行映射。实验结果表明,在工作频率为100 MHz时,FPGA与PC之间可正确传输数据并满足算法测试时不同测试用例的更换需求,具有较好的可观测性。     

基于模型的多目标优化问题方法研究

基于模型的多目标优化方法目的是创新一种通过黑箱评估的多目标函数优化算法,该算法从解空间上的混合分布中迭代生成候选解,并根据采样解的控制数来更新混合分布,求解过程的搜索偏向于Pareto最优解的集合。算法在解空间上寻找混合分布,使得混合分布的每个分量都是以帕累托最优解为中心的简并分布,并且每个预计的Pareto最优解都通过一个阈值距离均匀地分布在Pareto最优解集上,实验通过几个基准函数和方法证明了该算法的性能。     

Study on the application of active balancing device to solve the vibration problem for the rotor with bending fault

The rotor with bending faults that occurrs on the rotating machinery usually vibrates seriously. This paper investigates to apply the active balancing device on a flexible rotor with bending faults to solve the vibration problem. Two problems are studied by finite element method firstly： Where the balance actuator is fixed on the shaft and how much the balancing capacity of the active balancing device is needed. The experiment is then carried out on the test rig, which consists of a flexible rotor with bending faults. The test results indicate that the bending rotor peak vibration response can be decreased from 550~m to 40~tm below by using the active balancing device. The peak vibration response decreases approximately by 93 %. The synchronous vibration due to the rotor bending faults can be controlled effectively by using ac- tive balancing device. The active balancing device is especially adapted to solve the problem caused by thermal distortion with time-variation and randomness, which is varied with working conditions, thus it has good practical value in practice.     

兰州市城市河道综合整治规划探析——以兰州市南河道综合整治规划为例

本文以兰州市南河道综合整治规划为例,阐述了城市河道综合整治应考虑的诸要素,强调指出城市河道综合整治有别于传统意义上的河道整治,需多专业配合与协作。南河道的整治也为兰州市其他许多待整治河道提供了工程样板,总结南河道整治的工程经验更能开发思路,为兰州市其他河道治理提出更符合兰州市人文地理环境的治理方案。     

德士古渣油气化系统数学模拟

对德士古渣油气化系统进行了过程分析,建立了单元设备物料和热量衡算的数学模型,提出了计算气化炉微量组分的方法。运用序贯模块法对该系统进行了稳态模拟计算,结果同设计值和工厂值吻合较好。     

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

The emerging link between O-GlcNAcylation and neurological disorders

O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) is involved in the regulation of many cellular cascades and neurological diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and stroke. In the brain, the expression of O-GlcNAcylation is notably heightened, as is that of O-linked N-acetylglucosaminyltransferase (OGT) and β-N-acetylglucosaminidase (OGA), the presence of which is prominent in many regions of neurological importance. Most importantly, O-GlcNAcylation is believed to contribute to the normal functioning of neurons; conversely, its dysregulation participates in the pathogenesis of neurological disorders. In neurodegenerative diseases, O-GlcNAcylation of the brain’s key proteins, such as tau and amyloid-β, interacts with their phosphorylation, thereby triggering the formation of neurofibrillary tangles and amyloid plaques. An increase of O-GlcNAcylation by pharmacological intervention prevents neuronal loss. Additionally, O-GlcNAcylation is stress sensitive, and its elevation is cytoprotective. Increased O-GlcNAcylation ameliorated brain damage in victims of both trauma-hemorrhage and stroke. In this review, we summarize the current understanding of O-GlcNAcylation’s physiological and pathological roles in the nervous system and provide a foundation for development of a therapeutic strategy for neurological disorders.