Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria

Bafilomycin A1 (Baf) induces an elevation of cytosolic Ca²⁺ and acidification in neuronal cells via inhibition of the V-ATPase. Also, Baf uncouples mitochondria in differentiated PC12 (_dPC12), _dSH-SY5Y cells and cerebellar granule neurons, and markedly elevates their respiration. This respiratory response in _dPC12 is accompanied by morphological changes in the mitochondria and decreases the mitochondrial pH, Ca²⁺ and ΔΨm. The response to Baf is regulated by cytosolic Ca²⁺ fluxes from the endoplasmic reticulum. Inhibition of permeability transition pore opening increases the depolarizing effect of Baf on the ΔΨm. Baf induces stochastic flickering of the ΔΨm with a period of 20 ± 10 s. Under conditions of suppressed ATP production by glycolysis, oxidative phosphorylation impaired by Baf does not provide cells with sufficient ATP levels. Cells treated with Baf become more susceptible to excitation with KCl. Such mitochondrial uncoupling may play a role in a number of (patho)physiological conditions induced by Baf.     

Revisit the K-segment of the Southeast Indian Ridge for new evidence of hydrothermal plumes

During the first leg of a Chinese research cruise to the Southeast Indian Ridge (SEIR) in 2007, we revisited the K-segment of the SEIR and observed a water column turbidity anomaly at a CTD cast station. This station was located ~400 m from a dredge site on a plume anomaly detected in 1996 by US scientists. The characteristics of the turbidity anomaly detected in our survey are different from those observed 11 years previously, implying that either the detected anomalies have distinct and different plume sources or the robustness of the plume has changed in the intervening time. In addition, turbidity anomalies were observed at two localities on the K-segment in a deep tow-yo profile. If these two anomalies are not connected, the plume incidence calculated would be about 0.28, larger than the predicted value of 0.25 for a 65 mm/a spreading rate. This increase in plume incidence on the K-segment seems to be related to the influence of the St. Paul-Amsterdam hotspot, located about 300 km to the northwest.     

寄生于蝗虫六索线虫属一新种

在厦门岛东南部花生地土壤及疣蝗（Trilophidia anmulata)体内采集到一种六索线虫，研究发现与其它种有较大差异，命名为厦门六索线虫新虫Hexamamis Xiamenensis sp.nov，并指出它的鉴别特征。     

Highlights of recent advances in functional coordination polymers made in China

Coordination polymers (or metal-organic frameworks, MOFs), as one of the essences of crystal engineering and coordination chemistry, have attracted considerable atten-tion from chemists,     

A venomous arthropod in the Early Cambrian Sea

A number of recently evolved animals possess poison glands for feeding and/or defense.However,examples of such animals are rare in the fossil record.We report a fossil arthropod Isoxys curvirostratus from the Early Cambrian Chengjiang biota of China.This species is regarded as the oldest known venomous arthropod based on the presence of venomous glands in its head region.The adult animal is 2-5 cm long and the body is covered entirely with a carapace.The presence of large stalk eyes and a pair of stout grasping appendages with a terminal spine suggest it was raptorial.Interestingly,the two pear-shaped,three-dimensionally preserved objects that are present in the head region and at the base of the grasping appendages closely resemble the venom glands of some living arthropods in size,shape,and position.These features indicate that the presence of venomous predators could date back 520 million years.Furthermore,our observations suggest that the feeding strategies and organs adapted for this purpose had already reached a high level of diversity and anatomical sophistication in the Early Cambrian ecosystems.     

Normalized transfer function for characterizing conversion efficiency and harmonic distortion of all-optical sampling

A novel method for characterizing the nonlinearity of all-optical sampling is proposed based on the normalized transfer function.Simulation results demonstrate the effectiveness of our method.Furthermore,an all-optical sampling experiment is performed to verify our method.Both simulation and experiment show consistency between our method and the measurements.The method only requires normalization and polynomial fitting of the transfer curve,and enables direct expression of the nonlinearity with the coefficients of the normalized transfer function.     

Mean Motions in Ptolemy’s <Emphasis Type="Italic">Planetary Hypotheses</Emphasis>

In the Planetary Hypotheses, Ptolemy summarizes the planetary models that he discusses in great detail in the Almagest, but he changes the mean motions to account for more prolonged comparison of observations. He gives the mean motions in two different forms: first, in terms of ‘simple, unmixed’ periods and next, in terms of ‘particular, complex’ periods, which are approximations to linear combinations of the simple periods. As a consequence, all of the epoch values for the Moon and the planets are different at era Philip. This is in part a consequence of the changes in the mean motions and in part due to changes in Ptolemy’s time in the anomaly, but not the longitude or latitude, of the Moon, the mean longitude of Saturn and Jupiter, but not Mars, and the anomaly of Venus and Mercury, the former a large change, the latter a small one. The pattern of parameter changes we see suggests that the analyses that yielded the Planetary Hypotheses parameters were not the elegant trio analyses of the Almagest but some sort of serial determinations of the parameters based on sequences of independent observations.     

互联网对厂商营销的影响

分析了使用互联网平台在市场调查、分销渠道、沟通和新产品开发方面的作用 .并研究了互联网可以降低营销成本 ,促使产品的价格下降的趋势 .     

Performance analysis of optimal channel estimation and multiuser detection in a randomly-spread CDMA channel

<正> This paper analyzes performance of optimal channel estimation and multiuser detection(MUD) in a block-fading code-division multiple-access (CDMA) channel on the assumptions of randomspreading and large-system limit,by using the replica method developed in statistical mechanics.The authors find that the asymptotic spectral efficiency of the linear minimum mean-squared error(LMMSE) MUD which was proposed and analyzed by Evans and Tse in 2000 is indistinguishable fromthat of the optimal MUD for small system loads.Our results imply that performance of MUD scarcelyimproves even if one spends more computational cost than that of the LMMSE MUD,i.e.,at most thecube of the number of users,on the above-described conditions.     

Performance comparison of distributed state estimation algorithms for power systems

A newly proposed distributed dynamic state estimation algorithm based on the maximum a posteriori (MAP) technique is generalised and studied for power systems. The system model involves linear time-varying load dynamics and nonlinear measurements. The main contribution of this paper is to compare the performance and feasibility of this distributed algorithm with several existing distributed state estimation algorithms in the literature. Simulations are tested on the IEEE 39-bus and 118-bus systems under various operating conditions. The results show that this distributed algorithm performs better than distributed quasi-steady state estimation algorithms which do not use the load dynamic model. The results also show that the performance of this distributed method is very close to that by the centralized state estimation method. The merits of this algorithm over the centralized method lie in its low computational complexity and low communication load. Hence, the analysis supports the efficiency and benefits of the distributed algorithm in applications to large-scale power systems.