Superior machinability of steel enhanced with BN and MnS particles

The strategy that replacing part of MnS with BN was proposed in order to decrease the sulfur content in sulfur based free-cutting steel. The effects of BN and MnS inclusions on the microstructure and machinability of the steel were systematically investigated. The results show that most of the BN and MnS inclusions exist individually in the steel and only a small amount of them are in a composite state forming either isolated particles or clusters of particles. In the case of multi-phased steel, the theoretical calculation predicts that the volume of large BN particles should be 0.7 times of the volume of large MnS particles. The machinability of this type of BN and MnS alloy steel over a wide range of cutting speeds ranging from a low speed appropriate for drilling to a high speed appropriate for turning is confirmed as being equal to or superior to that of an MnS reference steel, even though the sulfur content in the composite steel is only half that of the MnS steel. The aptitude for cutting effect of 240 ppm nitrogen and 115 ppm boron in the composite steel is demonstrated to be equivalent or even better than 1000 ppm sulfur in MnS free-cutting steel.     

显著边缘直接引导的动态模糊图像盲复原方法

针对主动视觉中运动载体和云台抖动导致图像模糊的问题,提出一种显著边缘直接引导的动态模糊图像盲复原方法。为了克服经典 Canny 算子只能对边缘进行标注的缺陷,设计了图像边缘搜索-增强算法,并基于此提出了仅依据图像中显著边缘邻域完成点扩散函数优化估计的方法;为解决传统残差图像方法不能适应预测图像错位的问题,提出图像解模糊的递归残差修正算法来抑制复原图像波动;设计了图像复原的分层迭代处理流程,保证模糊图像复原的可靠性和精度。理想光照条件下的仿真表明,算法能准确恢复模糊图像的边缘,同时抑制复原图像中的波动。非理想光照条件下的仿真也验证了算法对环境有良好的适应性,具有较高的实际应用价值。     

Redundant and unique roles of coronin proteins in <Emphasis Type="Italic">Dictyostelium</Emphasis>

Dictyostelium discoideum harbors a short (CRN12) and a long coronin (CRN7) composed of one and two beta-propellers, respectively. They are primarily present in the cell cortex and cells lacking CRN12 (corA ⁻) or CRN7 (corB ⁻) have defects in actin driven processes. We compared the characteristics of a mutant cell line (corA ⁻ /corB ⁻) lacking CRN12 and CRN7 with the single mutants focusing on cytokinesis, phagocytosis, chemotaxis and development. Cytokinesis, uptake of small particles, and developmental defects were not enhanced in the corA ⁻ /corB ⁻ strain as compared to the single mutants, whereas motility and phagocytosis of yeast particles were more severely impaired. It appears that although both proteins affect the same processes they do not act in a redundant manner. Rather, they often act antagonistically, which is in accordance with their proposed roles in the actin cytoskeleton where CRN12 acts in actin disassembly whereas CRN7 stabilizes actin filaments and protects them from disassembly.     

浅谈管理会计技术方法的发展与创新

随着社会生产力的进步,管理水平的提高,管理会计技术方法也在不断发展和完善,战略管理会计是管理会计发展的新趋势,是一种具有创新意义的新型管理会计模式。     

额尔古纳河流域秋季浮游动物群落结构特征

2008年8—9月对额尔古纳河流域的重要水体呼伦湖、二卡湿地、乌兰泡、根河、伊敏河和哈乌尔河中的浮游动物进行调查,共鉴定浮游动物52种42属。其群落特征如下:1)轮虫共18种15属,占总种数的34.6%,枝角类9属14种,占26.9%,原生动物11属12种,占23.1%,桡足类7属8种,占15.4%;2)呼伦湖和二卡湿地浮游动物种类最多,分别为36种和34种,根河和哈乌尔河物种数均小于10种;3)浮游动物的密度和生物量均以二卡湿地最高,分别为4650.5ind/L,2.29mg/L,其次是呼伦湖和乌兰泡,分别为2274.5ind/L,1.35mg/L和4180.1ind/L,1.18mg/L,根河、哈乌尔河和伊敏河均较低。根据种类数、密度和生物量对额尔古纳河流域重要水体的水质状况进行评价:二卡湿地、呼伦湖和乌兰泡为中营养水体,根河、伊敏河和哈乌尔河为贫营养水体;呼伦湖浮游动物群落组成的改变显示其富营养化程度增加。     

Production of 316L stainless steel implant materials by powder metallurgy and investigation of their wear properties

In this study,the mechanical and wear properties of AISI 316L stainless steel implant materials,produced by powder metallurgy(P/M),were investigated.AISI 316L stainless steel powder was cold-pressed with 800 MPa of pressure and then sintered at 1200,1250 and 1300°C for 30 min as three sample groups.The microstructure,and mechanical and wear properties of the resulting steels were investigated.Light optical and scanning electron microscopiese were used to characterize the microstructure of the steels.Room temperature mechanical properties of the steels were determined by hardness measurements and impact tests.Wear was determined using the pin-on-disc wear test,and the results were evaluated according to weight loss.The results indicate that the sintering temperature,time and atmosphere are important parameters that affect the porous ratio of materials produced by P/M.Sintering at high temperature can eliminate small pores and make the residual pores spherical.The wear tests showed that the wear of the AISI 316L stainless steel implants changed depending on the sintering temperature and load.Spherical pores in the samples increase the wear resistance.Moreover,decreasing the porosity ratio of these materials improves all of their mechanical properties.     

基于DELMIA的变速箱虚拟装配仿真研究

针对变速箱零部件数量多、装配复杂等问题,文章提出以DELMIA为平台,对其进行虚拟装配过程仿真研究。为了解决变速箱装配方案这一难题,提出了基于拆卸法、组件识别法和装配关联图法三者相结合的装配序列规划方法,并在DELMIA环境下,对变速箱的箱体及其中一根轴的装配过程进行仿真,最后通过干涉碰撞检测和甘特图对其装配方案进行验证和优化。干涉分析与仿真验证表明,该方法能够有效地提高变速箱的装配质量、降低研制成本、缩短产品开发周期。     

Microsatellite instability in gastric cancer: molecular bases,clinical perspectives,and new treatment approaches

Gastric cancer is one of the most aggressive malignancies, with limited treatment options in both locally advanced and metastatic setting, resulting in poor prognosis. Based on genomic characterization, stomach tumour has recently been described as a heterogeneous disease composed by different subtypes, each of them with peculiar molecular aspects and specific clinical behaviour. With an incidence of 22% among all western gastric tumour cases, stomach cancer with microsatellite instability was identified as one of these subgroups. Retrospective studies and limited prospective trials reported differences between gastric cancers with microsatellite stability and those with instability, mainly concerning clinical and pathological features, but also in regard to immunological microenvironment, correlation with prognostic value, and responses to treatment. In particular, gastric cancer with microsatellite instability constitutes a small but relevant subgroup associated with older age, female sex, distal stomach location, and lower number of lymph-node metastases. Emerging data attribute to microsatellite instability status a favourable prognostic meaning, whereas the poor outcomes reported after perioperative chemotherapy administration suggest a detrimental role of cytotoxic drugs in this gastric cancer subgroup. The strong immunogenicity and the widespread expression of immune-checkpoint ligands make microsatellite instability subtype more vulnerable to immunotherapeutic approach, e.g., with anti-PD-L1 and anti-CTLA4 antibodies. Since gastric cancer with microsatellite instability shows specific features and clinical behaviour not overlapping with microsatellite stable disease, microsatellite instability test might be suitable for inclusion in a diagnostic setting for all tumour stages to guarantee the most targeted and effective treatment to every patient.     

A New Generalized Similarity-Based Topic Distillation Algorithm

The procedure of hypertext induced topic search based on a semantic relation model is analyzed, and the reason for the topic drift of HITS algorithm was found to prove that Web pages are projected to a wrong latent semantic basis. A new concept-generalized similarity is introduced and, based on this, a new topic distillation algorithm GSTDA（generalized similarity based topic distillation algorithm） was presented to improve the quality of topic distillation. GSTDA was applied not only to avoid the topic drift, but also to explore relative topics to user query. The experimental results on 10 queries show that GSTDA reduces topic drift rate by 10% to 58% compared to that of HITS（hypertext induced topic search） algorithm, and discovers several relative topics to queries that have multiple meanings.     

转子系统油膜失稳故障的振动实验分析

在单跨转子实验台上对油膜失稳故障(油膜涡动和油膜振荡)进行实验,分别对发生油膜失稳的转子稳定运行过程和转子升降速过程进行了振动测试·在油膜振荡期间,转子振动的时域波形呈现复杂的多周期性特点,轴心轨迹为扩散的不规则曲线,功率谱与全息谱表现出明显的分频(0 44倍频)特征·转子升降速过程的时频域分析揭示了转子油膜由涡动到振荡的发生发展过程·实验与分析的结果对研究转子油膜失稳故障现象、实现旋转机械的状态监测与预报有重要意义·