OPTIMAL MAINTENANCE AND REPLACEMENT OF EXTRACTION MACHINERY

This paper considers a problem of optimal preventive maintenance and replacement schedule of equipment devoted to extracting resources from known deposits. Typical examples are oil drills, mine shovels, etc. At most one replacement of the existing machinery by a new one is allowed. The problem is formulated as an optimal control problem subject to the state constraint that the remaining deposit at any given time is nonnegative. We show that the optimal preventive maintenance, production rates, and the replacement and salvage times of the existing machinery and the new one, if required, can be obtained by solving sequentially a series of free-end-point optimal control problems. Moreover, an algorithm based on this result is developed and used to solve two illustrative examples.     

Blind Equalization Algorithm Based on MCMA and DSE-CMA

A new blind equalization algorithm based on the modified constant modulus algorithm （MCMA） and dithered signederror constant modulus algorithm （DSE-CMA） is proposed. This dithered signed-error MCMA （DSE-MCMA） can not only reduce the computational complexity, but also recover the phase rotation in the complex channel. Simulation results have verified the analysis and indicated the good property of DSE-MCMA.     

交流阻抗技术研究巯基丙酸/中性红修饰电极上DNA的响应

中性红(NR)可吸附在巯基丙酸自组装修饰金电极表面,并进而与DNA发生嵌插作用.以交流阻抗技术研究了DNA在巯基丙酸自组装/中性红修饰电极上的响应.结果表明,交流阻抗方法不仅可以反映DNA与小分子间发生的作用,还可以对DNA进行定量分析,响应在DNA浓度为0.4～8mg·L-1范围内呈线性关系,相关系数r=0.9973,检出下限为0.03 mg·L-1.该法是一种快速、简便、廉价的研究DNA及与小分子相互作用的方法.     

基于模糊评价法的景区游客满意度实证研究——以南京中山陵园风景区为例

以著名的5A级景区中山陵园风景区为例,运用模糊评价法测评游客满意度,并做人口统计学特征满意度差异研究.结果显示:游客满意度不高;不同月收入、年龄、文化程度和职业的游客对部分因子的满意度以及总体印象的评价存在显著差异.     

基于知识的成卷方法及在MATBAS系统中的实现

本文以 MATBAS(高等数学试题库及计算机辅助命题和评估软件系统)为背号,论述了基于知识的成卷方法。在分析各类考试特点与规律的基础上,提出三类考试模型。在成卷推理中综合使用可信度推理、启发式推理、规划及约束方法。为了使系统控制更灵活,能够生成若干风格不同的等价试卷,还提出了知识层次划分的思想,引入“元知识”的概念,把知识处理结构设计为耦合式的知识库系统。该成卷方法不仅适用于高等数学命题,也适应于别的课程考试。     

Fe(CN)_6~(3-/4-)在铂电极上氧化还原过程的表面拉曼光谱研究(英文)

本文运用共聚焦显微拉曼仪结合特殊的电极表面粗糙方法首次获得了Fe(CN)_6~(3-/4-)在铂电极表面氧化还原过程的拉曼光谱图。研究结果表明Fe(CN)_6~(3-)在电极表面的吸附能力比Fe(CN)~(4-)强,它们都是通过CN上的N原子和电极表面成键而发生化学吸附的。     

钢板-砼组合加固钢筋砼梁的研究及应用进展

钢板-混凝土组合加固技术是钢筋混凝土梁加固的一种的新方法.简介了目前关于钢板-混凝土组合加固梁抗弯和抗剪承载力研究的成果,分析考虑界面滑移、二次受力等因素对于承载能力影响的研究现状,探讨了该加固技术试验研究方法及工程应用情况.通过对现有研究成果的归纳和总结,分析了该技术的主要特点与不足,并指出了有关钢板-混凝土组合加固方面值得进一步研究的问题.     

缺帧环境下遮挡图像的特征优化提取方法研究

针对缺帧环境下图像的遮挡问题,提出一种新的特征优化提取方法。建立缺帧环境下遮挡图像采集模型,在此基础上,利用正方形网格建立立体模型,实现图像采集。通过阈值降噪法完成对遮挡图像的降噪滤波处理。DCS-LBP算子通过梯度方向上变化的灰度值实现编码,效果不佳,通过GCS-LDP算子对其进行优化,将二者结合在一起对缺帧环境下遮挡图像施行编码,获取最后的直方图,将该直方图看作遮挡图像的特征,完成遮挡图像特征的优化提取。实验结果表明,所提方法能够有效对缺帧环境下遮挡图像进行预处理,且识别效率高,计算量少。     

Protein arginine deiminase 4: a target for an epigenetic cancer therapy

The recent approvals of anticancer therapeutic agents targeting the histone deacetylases and DNA methyltransferases have highlighted the important role that epigenetics plays in human diseases, and suggested that the factors controlling gene expression are novel drug targets. Protein arginine deiminase 4 (PAD4) is one such target because its effects on gene expression parallel those observed for the histone deacetylases. We demonstrated that F- and Cl-amidine, two potent PAD4 inhibitors, display micromolar cytotoxic effects towards several cancerous cell lines (HL-60, MCF7 and HT-29); no effect was observed in noncancerous lines (NIH 3T3 and HL-60 granulocytes). These compounds also induced the differentiation of HL-60 and HT29 cells. Finally, these compounds synergistically potentiated the cell killing effects of doxorubicin. Taken together, these findings suggest PAD4 inhibition as a novel epigenetic approach for the treatment of cancer, and suggest that F- and Cl-amidine are candidate therapeutic agents for this disease.