全文获取类型
收费全文 | 2275篇 |
免费 | 98篇 |
国内免费 | 137篇 |
专业分类
系统科学 | 90篇 |
丛书文集 | 78篇 |
教育与普及 | 54篇 |
理论与方法论 | 3篇 |
现状及发展 | 20篇 |
研究方法 | 15篇 |
综合类 | 2250篇 |
出版年
2024年 | 11篇 |
2023年 | 17篇 |
2022年 | 44篇 |
2021年 | 62篇 |
2020年 | 40篇 |
2019年 | 19篇 |
2018年 | 26篇 |
2017年 | 32篇 |
2016年 | 30篇 |
2015年 | 56篇 |
2014年 | 74篇 |
2013年 | 47篇 |
2012年 | 86篇 |
2011年 | 111篇 |
2010年 | 90篇 |
2009年 | 101篇 |
2008年 | 112篇 |
2007年 | 94篇 |
2006年 | 100篇 |
2005年 | 74篇 |
2004年 | 54篇 |
2003年 | 102篇 |
2002年 | 125篇 |
2001年 | 86篇 |
2000年 | 70篇 |
1999年 | 117篇 |
1998年 | 75篇 |
1997年 | 92篇 |
1996年 | 73篇 |
1995年 | 68篇 |
1994年 | 66篇 |
1993年 | 67篇 |
1992年 | 47篇 |
1991年 | 53篇 |
1990年 | 45篇 |
1989年 | 45篇 |
1988年 | 46篇 |
1987年 | 20篇 |
1986年 | 15篇 |
1985年 | 8篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1978年 | 2篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1965年 | 1篇 |
排序方式: 共有2510条查询结果,搜索用时 15 毫秒
71.
三维地学建模技术与Kriging方法在固体矿产储量计算中的应用 总被引:4,自引:0,他引:4
结合Kriging方法在计算机上的实现和应用,介绍了运用三维地学建模技术生成矿体的三维品位模型的原理流程以及关键技术,并在此基础上进行矿产资源储最计算.其基本流程为:根据实际地质勘探数据生成矿体三维实体模型;在实体tin模型内部应用块模型方法进行划分,建立矿体块体模型;利用Kriging方法进行插值,生成矿体的品位模型... 相似文献
72.
施工企业经营风险是指企业在经营中对未来经营环境中的不确定因素与多变性无法全部或精确预测所造成预计支出与收益偏离实际的风险。企业经营风险是在经营过程中产生的,因此,经营风险贯穿于企业生产经营的全过程。 相似文献
73.
讨论了导体与电介质同时存在情况下的电像法问题,指出了文献[1-2]中关于这一问题所出现的一些错误,并给出了正确的解答. 相似文献
74.
光谱法研究一种含咪唑啉酮类衍生物与牛血清白蛋白的相互作用 总被引:1,自引:1,他引:0
应用荧光光谱及紫外可见光谱的方法研究了2-氨基-5-苯亚甲基-4H-咪唑啉-4-酮衍生物(BPH5)与牛血清白蛋白(BSA)的相互作用.实验发现BPH5能强烈猝灭牛血清白蛋白的荧光强度,其荧光猝灭机理为动态猝灭.在此基础上计算了二者相互作用的结合常数、结合位点数及△H,△G,△S等热力学参数等.结果表明BPH5与BSA以1∶1结合,其反应主要是熵驱动的,相互作用力主要为疏水作用力.根据F(o)rster无辐射能量转移理论计算了给体(BSA)与受体(BPH5)之间的结合距离. 相似文献
75.
Lei Chen Cong-Fa Huang Yi-Cun Li Wei-Wei Deng Liang Mao Lei Wu Wen-Feng Zhang Lu Zhang Zhi-Jun Sun 《Cellular and molecular life sciences : CMLS》2018,75(11):2045-2058
The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that the NLRP3 inflammasome was over-expressed in human HNSCC tissues and that the IL-1β concentration was increased in the peripheral blood of HNSCC patients. Additionally, elevated NLRP3 inflammasome levels were detected in tumor tissues of Tgfbr1/Pten 2cKO HNSCC mice, and elevated IL-1β levels were detected in the peripheral blood serum, spleen, draining lymph nodes and tumor tissues. Blocking NLRP3 inflammasome activation using MCC950 remarkably reduced IL-1β production in an HNSCC mouse model and reduced the numbers of myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated macrophages (TAMs). Moreover, inhibiting NLRP3 inflammasome activation increased the numbers of CD4+ and CD8+ T cells in HNSCC mice. Notably, the numbers of exhausted PD-1+ and Tim3+ T cells were significantly reduced. A human HNSCC tissue microarray showed that NLRP3 inflammasome expression was correlated with the expression of CD8 and CD4, the Treg marker Foxp3, the MDSC markers CD11b and CD33, and the TAM markers CD68 and CD163, PD-1 and Tim3. Overall, our results demonstrate that the NLRP3 inflammasome/IL-1β pathway promotes tumorigenesis in HNSCC and inactivation of this pathway delays tumor growth, accompanied by decreased immunosuppressive cell accumulation and an increased number of effector T cells. Thus, inhibition of the tumor microenvironment through the NLRP3 inflammasome/IL-1β pathway may provide a novel approach for HNSCC therapy. 相似文献
76.
Power efficiency and link reliability are of great importance in hierarchical wireless sensor networks (HWSNs),especially at the key level,which consists of sensor nodes located only one hop away from the sink node called OHS.The power and admission control problem in HWSNs is comsidered to improve its power efficiency and link reliability.This problem is modeled as a non-cooperative game in which the active OHSs are considered as players.By applying a double-pricing scheme in the definition of OHSs’ utility function,a Nash Equilibrium solution with network properties is derived.Besides,a distributed algorithm is also proposed to show the dynamic processes to achieve Nash Equilibrium.Finally,the simulation results demonstrate the effectiveness of the proposed algorithm. 相似文献
77.
一维双极粘滞量子流体力学模型解的存在性 总被引:1,自引:0,他引:1
研究了一类一维稳态双极半导体方程的粘滞量子流体力学模型.该模型包含关于粒子浓度和电流密度的连续方程以及电势Poisson方程的耦合方程组,其中含有三阶量子修正项和二阶粘滞项.该问题在有界区间(0,1)中讨论,并通过边界条件的假设将原方程组变形为常见的形式,得到原问题的等价问题.用截断方法将等价问题正则化,并得到正则化问题解的先验估计.利用Leray-Schauder不动点定理证明正则化问题解的存在性,最后通过L∞估计证明正则化问题的解即为原问题的解,从而证明了原双极粘滞量子流体力学模型存在稳态解. 相似文献
78.
目的 观察 MPTP慢性帕金森病小鼠海马氧化应激指标及细胞凋亡相关蛋白的表达.方法 应用MPTP制备慢性帕金森病模型,观察行为学改变,Morris水迷宫实验,检测模型组和对照组小鼠海马内超氧化物歧化酶(SOD)、还原型谷胱甘肽(GSH)及丙二醛(MDA)舍量变化,以及免疫组织化学方法、RT-PCR方法、Western blot方法检测海马Bax和Bel-2蛋白表达.结果 慢性帕金森病模型小鼠行为学特点为震颤、活动减少;水迷宫实验结果提示认知功能降低;与对照组海马比较:模型组海马SOD、GSH含量均下降,而MDA含量升高(P〈0.05);模型组海马Bax蛋白表达增高,而Bel-2蛋白表达下降(P〈0.05).结论 氧化应激在慢性帕全森病认知功能障碍发病机制中起重要作用,而Bax和Bcl-2蛋白参与了氧化应激诱导海马神经元凋亡的调控过程. 相似文献
79.
Lei Jiang ChunFang Cai YongDong Zhang ShengYi Mao YongGe Sun KaiKai Li Lei Xiang ChunMing Zhang 《科学通报(英文版)》2012,57(11):1311-1319
U-bearing sandstones from the Dongsheng deposit in Ordos Basin contain abundant C15-C18 fatty acids. The fatty acids may have been derived from modern and ancient organisms including organisms from the intervals of U mineralization. A certain amount of i15:0, a15:0, a17:0 fatty acids coexist with small amounts of i17:1ω7c and 10me16:0, characteristic biomarkers of Desulfovibrio and Desulfobacter sp., respectively. This indicates the existence of sulfate-reducing bacteria (SRB) in the sandstones. The presence of sulfur-oxidizing bacteria (SOB), such as Beggiatoa and Thioploca, is indicated by significant amounts of 16:1ω7c and 18:1ω7c fatty acids. The existence of the SRB in the deposit, as inferred from the fatty acids, is consistent with results from fossilized microorganisms and isotopic compositions of ore-stage pyrite. This suggests that the environment may have been favorable for the SRB to grow since ore formation (9.8-22 Ma). The bacteria may have degraded hydrocarbons directly, or indirectly utilized hydrocarbons degraded by oxic microbes in the deposits. This process may have produced 12C-rich calcite and prominent baseline humps of unresolved complex mixtures (UCM), and 25-demethylated hopanes and tricyclic terpanes. The existence of sulfur-oxidizing bacteria and sulfate-reducing bacteria in the deposit may have resulted in bacterial sulfate reduction to sulfide, re-oxidization of the sulfide to sulfate and subsequent reduction of the sulfate to sulfide. This assertion is supported by ore-stage pyrite with δ34S values as low as-39.2‰, and the lightest sulfate (about 11‰) measured during the Phanerozoic, a difference of more than 46‰. 相似文献
80.
文章论述了掘进机电气系统所采用的控制方式以及保护方式,结合掘进机电气系统原理,提出电气系统故障点分布,进行分析,使维修人员能够快捷地判断和处理故障。 相似文献