大型客运站到发线数量计算研究

文章是在考虑目前我国客运专线大规模建设的前提下,讨论客运专线引入大型客运站后,到发线数量的确定问题.在分析了影响客运专线到发线数量的因素基础上,提出列车换算对数法来计算到发线数量.以成都新站为例进一步验证了计算方法的准确性.     

绘本插图的创作特征

绘本是一种图画与文学相结合的特有的图书形式,尤其强调用图画来讲故事.绘本插图的创作已上升为一个纯然的艺术形式,精致优美的绘画和简练生动的语言融为一体,是绘画和语言两种艺术的完美结合.本文主要是对绘本图书及其插图的创作特征进行探讨.     

市政建设工程质量监督的重要性

市政基础设施作为城市建设中的一个重要环节,具有投资额大、涉及面广、带动作用强等特点,是城市生活和社会发展的基础条件,与广大市民生产和生活密切相关,对社会各项事业的发展具有重要的拉动作用.     

Mechanisms functional underlying the characteristics structural and of acupoints

Acupoints are particular areas on the surface of the body through which the Qi and blood of the Zang-fu organs and meridians flow. Acupoints can respond to stimuli and reflect syndromes. Research on the essential morphology of acupoints has two key focuses： anatomical structure and physiological func- tion. The structure is the material and anatomical basis for the function, while the function is the manifes- tation of the structure. The two factors not only have profound significance for our understanding of the essence of acupoints, but also have great value for clinical acupuncture and moxibustion practice. Based on the structural and functional characteristics of meridians under different physiological and pathological con- ditions, this paper illustrates the essence of acupoints and explores the rules and biological basis of the acu- point functions induced by acupuncture and moxibustion.     

Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration

Leber congenital amaurosis (LCA) is a blinding retinal disease that presents within the first year after birth. Using exome sequencing, we identified mutations in the nicotinamide adenine dinucleotide (NAD) synthase gene NMNAT1 encoding nicotinamide mononucleotide adenylyltransferase 1 in eight families with LCA, including the family in which LCA was originally linked to the LCA9 locus. Notably, all individuals with NMNAT1 mutations also have macular colobomas, which are severe degenerative entities of the central retina (fovea) devoid of tissue and photoreceptors. Functional assays of the proteins encoded by the mutant alleles identified in our study showed that the mutations reduce the enzymatic activity of NMNAT1 in NAD biosynthesis and affect protein folding. Of note, recent characterization of the slow Wallerian degeneration (Wld(s)) mouse model, in which prolonged axonal survival after injury is observed, identified NMNAT1 as a neuroprotective protein when ectopically expressed. Our findings identify a new disease mechanism underlying LCA and provide the first link between endogenous NMNAT1 dysfunction and a human nervous system disorder.     

A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia

Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Its pathophysiology is largely unknown, and few genetic influences have been defined. To identify common variants contributing to NOA in Han Chinese men, we performed a three-stage genome-wide association study of 2,927 individuals with NOA and 5,734 controls. The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)). These findings implicate genetic variants at 1p13.3, 1p36.32 and 12p12.1 in the etiology of NOA in Han Chinese men.     

SAm级防撞活动护栏碰撞仿真分析

针对目前高速公路中央分隔带开口处活动护栏防撞等级较低的问题,提出了一种SAm级混凝土活动护栏及一种新型连接装置.基于有限元的方法,建立车辆与护栏的碰撞模型,通过LS-DYNA对车辆与护栏碰撞过程进行求解,根据不同车型的碰撞结果分别在缓冲,阻挡和导向性能上对护栏的安全性能进行评价,其中小型车辆与护栏碰撞后的OIV(Occ...     

燃烧合成超细ITO粉体

以In粒和Sn粒为原料,尿素为燃料,柠檬酸为添加剂,燃烧合成ITO(掺锡氧化铟)粉体,利用粉末X射线衍射、扫描电子显微镜对产品进行表征,并研究柠檬酸(C6H8O7)对燃烧产物的影响.结果表明,以尿素为燃料燃烧合成是制备ITO粉体的有效途径,添加剂柠檬酸能有效抑制粉体的团聚,使颗粒分散性变好,得到颗粒细小均匀的ITO粉体...     

奇特征有限域上二次函数的Walsh变换的值分布

设P为奇素数,n为一个正整数,Q(x)是有限域Fnp上的任意一个二次型.运用有关二次型的理论确定出了Q(x)的Walsh变换的值分布,进而得到了Fnp上任意一个二次函数Q(x) Trn1(ax)的Walsh变换的值分布.此结果可以用于确定序列集的相关分布以及线性码的权重分布等问题的研究.     

简评哈耶克对科学主义的批判

哈耶克在20世纪40年代对科学主义的批判，是人类思想史中第一次正面地对科学主义思潮进行的批判。他采取了一条清晰的批判路径，从多个方面论证了科学方法滥用的危害，从而揭示出科学主义思潮暗含的诸多危险，如将导致人们对计划的渴望，以及极权社会的出现，进而批判了科学主义的狂妄和人类对理性的盲目崇拜倾向。