Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

The pathways of intracellular traffic involved in antigen processing and presentation have been defined by immunoelectron microscopy. The export pathway for class II histocompatibility molecules and the antigen import pathway meet in a peripheral endocytic compartment having all the molecular machinery believed to be required for antigen processing and presentation, including internalized surface immunoglobulins, proteolytic enzymes and invariant chains. This compartment defines a site where peptides from endocytosed antigen can bind class II molecules en route to the cell surface for presentation to T cells.     

Presentation of viral antigen controlled by a gene in the major histocompatibility complex

We describe a mutant human cell line (LBL 721.174) that has lost a function required for presentation of intracellular viral antigens with class I molecules of the major histocompatibility complex (MHC), but retains the capacity to present defined epitopes as extracellular peptides. The cell also has a defect in the assembly and expression of class I MHC molecules, which we show can be restored by exposure of the cells to a peptide epitope. This phenotype suggests a defect in the association of intracellular antigen with class I molecules similar to that described for the murine mutant RMA-S (ref. 5), but in the present case the genetic defect can be mapped within the MHC locus on human chromosome 6.     

Residues of the variable region of the T-cell-receptor beta-chain that interact with S. aureus toxin superantigens

The alpha beta T-cell antigen receptor (TCR) recognizes antigenic peptides in the context of self major histocompatibility complex (MHC) molecules. The specificity of recognition of MHC plus antigen is generally determined by a combination of the variable elements of alpha- and beta-chains of the TCR. Several types of antigen, however, have been identified that, when bound to MHC molecules, stimulate T cells bearing particular variable-region beta-chain (V beta) elements irrespective of the other variable components of the TCR. These have been termed 'superantigens', and here we are concerned with one type of superantigen, the toxins produced by Staphylococcus aureus. T cells have been found that bear closely related members of the same V beta family but respond differently to S. aureus toxins; in particular, cells bearing the human V beta 13.2 element respond to toxin SEC2, whereas cells bearing human V beta 13.1 do not. We have now defined the residues of the V beta element responsible for this difference, and find that they reside in a region thought to lie on the side of the TCR molecule, away from the conventional antigen/MHC-binding site. The evolutionary conservation of this site may be due to its having an important role in some function of the TCR other than the binding of conventional antigen plus MHC.     

二维DWT的分裂向量基新算法

本文导出了一种快速计算二维离散W变换的新算法——分裂向量基二维快速W变换算法(Split—Vector radix fast W traneform简称SVR—FWT)这种新算法具有概念清晰,结构简单及计算量少的特点。     

高T_c氧化物超导体的LO耦合机制

本文利用Eliashberg超导理论,分析了高T_c氧化物超导体的LO耦合机制,给出了此类超导体e-LO耦合参数λ、库仑赝势μ~n、临界温度T_c和0K能隙△_0与T_c比值的计算公式。     

CO-W-P刷镀层的晶化动力学与热模具寿命

研究了 ＣＯ－Ｗ－Ｐ电刷镀层加热时结构的转变。实验测定了镀层的等温和变温晶化综合动力学曲线及各种动力学参数。提出了瞬时晶化温度的概念。详细分析了晶化过程中硬度的变化，发现晶化伴随有一个硬化效果很强烈的沉淀过程。ＣＯ－Ｗ－Ｐ刷镀层能显著增进热模具的使用寿命，主要原因在于模具成形时，同时发生晶化和沉淀析出过程，产生二次硬化效应，提高了模具表层的红硬性以及热磨损抗力。     

PRBS信号发生和数据采集系统

本文介绍一种可用于系统辨识的伪随机二位式序列(PRBS)信号发生和数据采集系统,阐述了该系统的原理、电路及程序结构,并讨论了该系统的运用。