Genetic and pharmacological models of cholinergic supersensitivity and affective disorders

Summary Increased muscarinic sensitivity has been associated with altered hormonal states (hypothyroidism and hyperadrenocorticism), chronic administration of muscarinic antagonists or antidepressants with muscarinic actions, selective breeding for anticholinesterase sensitivity, and certain inbred strains of rats and mice. Thus, both genetic and environmental factors may influence muscarinic receptor sensitivity. The reasonably detailed studies on the selectively-bred rats have revealed that the Flinders Sensitive Line (FSL) rats weigh less, are less active, are more sensitive to muscarinic agonists and to stressors, and have higher concentrations of hippocampal and striatal muscarinic receptors than normal, or the selectively-bred, Flinders Resistant Line (FRL) rats. Thus, there are a number of parallels between FSL rats and depressed humans. The FSL rats may be the first animal model of depression to mimic the actual trait of depression, and not just the state.     

拟牛顿流的压力投影稳定化低阶有限元方法分析

作者对一般的拟牛顿流问题,针对线性/线性和线性/常数两种低阶有限元空间,提出了一种新的稳定化方法.该方法可以看成压力投影稳定化方法从Stokes问题到拟牛顿流问题的推广与发展.在速度属于Wl,r(Ω),压力属于Lr'(Ω) (1/r+1/r'=1)下,作者给出了误差估计.服从幂律及Carreau分布的拟牛顿流问题可看成...     

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Einwirkung von N-Brom-succinimid aufΔ 4-3-Keto-steroide

Summary The bromination of ⁴-3-keto-steroids with the aid of N-bromo-succinimide takes place in 6-position, that is in allyl-position and not in-position to the keto group. By splitting off hydrogen bromide from these 6-bromo-compounds, ^4;6-3-keto-steroids are obtained in known manner.

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53. Mitteilung der Reihe «Über Steroide» (52. Mitt. s. Helv. chim. acta29, 1231 (1946).     

Asynchronous nested optimization algorithms and their parallel implementation

Large scale optimization problems can only be solved in an efficient way, if their special structure is taken as the basis of algorithm design. In this paper we consider a very broad class of large — scale problems with special structure, namely tree structured problems. We show how the exploitation of the structure leads to efficient decomposition algorithms and how it may be implemented in a parallel environment.     

Mise en évidence d'une nouvelle forme combinée de l'acide glutamique dans le latex d'Euphorbia characias L

Summary The hydro-alcoholic extract ofEuphorbia characias Latex contains one unknown amino acid and one new combined form of glutamic acid, isolated by preparative electrophoresis on cellulose powder.

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Nous exprimons nos remerciements à Mrs. les ProfesseursBoulanger etG. Biserte pour les conseils reçus au cours de ce travail.