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排序方式: 共有54条查询结果,搜索用时 703 毫秒
31.
一类高阶非线性系统的零解稳定性 总被引:1,自引:0,他引:1
由Барбащин公式得到的四阶常系数线性系统的Ляпунов函数出发,通过类比法构造了一类四阶非线性系统的Ляпунов函数,并由此得到了这些系统零解的全局渐近稳定性的充分条件 相似文献
32.
In Ha Cho Min Jung Lee Dae Hwan Kim Bora Kim Jeomil Bae Kyu Yeong Choi Seon-Myung Kim Yun Hyun Huh Kun Ho Lee Chong-Hyun Kim Woo Keun Song 《Cellular and molecular life sciences : CMLS》2013,70(22):4369-4383
Actin plays a fundamental role in the regulation of spine morphology (both shrinkage and enlargement) upon synaptic activation. In particular, actin depolymerization is crucial for the spine shrinkage in NMDAR-mediated synaptic depression. Here, we define the role of SPIN90 phosphorylation/dephosphorylation in regulating actin depolymerization via modulation of cofilin activity. When neurons were treated with NMDA, SPIN90 was dephosphorylated by STEP61 (striatal-enriched protein tyrosine phosphatase) and translocated from the spines to the dendritic shafts. In addition, phosphorylated SPIN90 bound cofilin and then inhibited cofilin activity, suggesting that SPIN90 dephosphorylation is a prerequisite step for releasing cofilin so that cofilin can adequately sever actin filaments into monomeric form. We found that SPIN90 YE, a phosphomimetic mutant, remained in the spines after NMDAR activation where it bound cofilin, thereby effectively preventing actin depolymerization. This led to inhibition of the activity-dependent redistribution of cortactin and drebrin A, as well as of the morphological changes in the spines that underlie synaptic plasticity. These findings indicate that NMDA-induced SPIN90 dephosphorylation and translocation initiates cofilin-mediated actin dynamics and spine shrinkage within dendritic spines, thereby modulating synaptic activity. 相似文献
33.
An amino-acid substitution involved in phenylketonuria is in linkage disequilibrium with DNA haplotype 2 总被引:10,自引:0,他引:10
Phenylketonuria (PKU) is an autosomal recessive human genetic disorder caused by a deficiency of hepatic phenylalanine hydroxylase (PAH, phenylalanine 4-monooxygenase, EC 1.14.16.1). PKU is a common inborn error of amino-acid metabolism in caucasian populations and approximately 1 in 50 individuals are carriers of a PKU allele. To define the molecular basis of PKU, we characterized twelve restriction fragment-length polymorphism (RFLP) haplotypes of the PAH locus in the northern European population and observed that 90% of the PKU alleles in this population are confined to four common RFLP haplotypes. We have recently reported a splicing mutation in the PAH gene that is associated with RFLP haplotype 3 which is present at about 40% of mutant alleles. We now report the molecular lesion associated with the RFLP haplotype 2 mutant allele. This defect is caused by a C-to-T transition in exon 12 resulting in an amino-acid substitution (Arg to Trp) at residue 408 of PAH. Direct hybridization analysis of the point mutation using a specific oligonucleotide probe demonstrated that this mutation is also in linkage disequilibrium with RFLP haplotype 2 alleles that make up about 20% of mutant PAH genes. 相似文献
34.
This paper presents an integration methodology for ma chining and measuring processes using OMM (On-Machine Measurement) technology b ased on CAD/CAM/CAI integration concept. OMM uses a CNC machining center as a me asuring station by changing the tools into measuring probes such as touch-type, laser and vision. Although the measurement accuracy is not good compared to tha t of the CMM (Coordinate Measuring Machine), there are distinctive advantages us ing OMM in real situation. In this paper, two topics a... 相似文献
35.
DNA sequence alignment algorithms in computational molecular biology have been improved by diverse methods. In this paper, we propose a DNA sequence alignment that uses quality information and a fuzzy inference method developed based on the characteristics of DNA fragments and a fuzzy logic system in order to improve conventional DNA sequence alignment methods that uses DNA sequence quality information. In conventional algorithms, DNA sequence alignment scores are calculated by the global sequence alignment algo- rithm proposed by Needleman-Wunsch, which is established by using quality information of each DNA fragment. However, there may be errors in the process of calculating DNA sequence alignment scores when the quality of DNA fragment tips is low, because only the overall DNA sequence quality information are used. In our proposed method, an exact DNA sequence alignment can be achieved in spite of the low quality of DNA fragment tips by improvement of conventional algorithms using quality information. Mapping score param- eters used to calculate DNA sequence alignment scores are dynamically adjusted by the fuzzy logic system utilizing lengths of DNA fragments and frequencies of low quality DNA bases in the fragments. From the experiments by applying real genome data of National Center for Biotechnology Information, we could see that the proposed method is more efficient than conventional algorithms. 相似文献
36.
CL Cheung KS Lau AY Ho KK Lee SC Tiu EY Lau J Leung MW Tsang KW Chan CY Yeung YC Woo EY Cheung VH Hung HK Pang CS Hung PC Sham AW Kung 《Nature genetics》2012,44(9):1026-1029
Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of thyrotoxicosis. We conducted a genome-wide association study (GWAS) and a replication study with a total of 123 southern Chinese with TPP (cases) and 1,170 healthy controls and identified a susceptibility locus on chromosome 17q24.3 near KCNJ2 (rs312691: odds ratio (OR) = 3.3; P(meta-analysis) = 1.8 × 10(-14)). All subjects with TPP also had Graves' disease, and subsequent TPP versus Graves' disease comparison confirmed that the association at 17q24.3 was specific to TPP. The area under the curve (AUC) of rs312691 genotype for risk prediction of TPP in subjects with Graves' disease was 0.73. Expression quantitative trait locus (eQTL) analysis identified SNPs in the region flanking rs312691 (±10 kb) that could potentially affect KCNJ2 expression (P = 0.0001). Our study has identified a susceptibility locus associated with TPP and provides insight into the causes of TPP. 相似文献
37.
38.
Won-Je Kim Woo Sung Son Kyoung-Seok Ryu Seung-Kyu Lee Kwang-Hyun Choi Jong-Sun Lee Bong-Jin Lee 《科学通报(英文版)》2014,59(32):4274-4282
Potent inhibitors of human peptide deformylase (HsPDF) were screened using known PMT analog inhibi- tors of bacterial peptide deformylase. Forty-three species of PMT analogs that are non-peptidyl bacterial PDF inhibitors like actinonin were selected using virtual screening GOLD. Ten species out of 43 that could bind to HsPDF were selected and their antitumor activities were tested. Among them, four species (PMT-172, PMT-173, PMT-199, and PMT-201) showed excellent growth inhibition of cancer cell in the MTT assay. HsPDF-PMT binding was confirmed through a 1H-CPMG-T2 filter NMR experiment leading to a significant change in peak intensity for PMT-172 and PMT-199. These results suggest that PMT analogs could possibly interact with HsPDF and be a novel anticancer drug candidate. 相似文献
39.
This paper seeks to further substantiate and appreciate the importance of West Churchman’s pragmatic philosophy, and to propose
the development of what we call the participatory and rhizomatic systems approach. The aim of rhizomatics is to create a deterritoriazation
of current social fields and to make sense of the creation of the rhizomatic networks and ethics for the marginalized group
in practice. This paper takes the contributions of Gilles Deleuze and Felix Guattari’s notion of rhizome on ethical reasoning
and incorporates them into a test. It examines how ethics for the marginalized group can assist in appreciating and developing
ethical management of any systemic intervention. The paper looks into what ethics for the marginalized group is and how it
is achieved in the context of rhizomatic networks.
相似文献
Jae Eon YuEmail: |
40.
Sungho Moon So Yeon Park Hyun Woo Park 《Cellular and molecular life sciences : CMLS》2018,75(13):2303-2319
The Hippo tumor suppressor pathway, which is well conserved from Drosophila to humans, has emerged as the master regulator of organ size, as well as major cellular properties, such as cell proliferation, survival, stemness, and tissue homeostasis. The biological significance and deregulation of the Hippo pathway in tumorigenesis have received a surge of interest in the past decade. In the current review, we present the major discoveries that made substantial contributions to our understanding of the Hippo pathway and discuss how Hippo pathway components contribute to cellular signaling, physiology, and their potential implications in anticancer therapeutics. 相似文献