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61.
Balanced synthesis of light and heavy chains of immunoglobulin G 总被引:5,自引:0,他引:5
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Ellis PJ Peckham G Smith SD Houghton JT Morgan CG Rodgers CD Williamson EJ 《Nature》1970,228(5267):139-143
This article describes the temperature profiles through the atmosphere that are being obtained from the radiometer on Nimbus 4. 相似文献
66.
Elvin SJ Williamson ED Scott JC Smith JN Pérez De Lema G Chilla S Clapham P Pfeffer K Schlöndorff D Luckow B 《Nature》2004,430(6998):417
Mecsas and colleagues suggest that a deficiency in the chemokine receptor CCR5 in humans is unlikely to confer protection against plague, based on their study of Yersinia pestis infection in Ccr5-deficient mice. They were testing the hypothesis that a mutation in the CCR5 gene, frequently found in Caucasians, may have been selected for in the past because it provided protection against (bubonic) plague; the mutation, called CCR5Delta32, is characterized by a 32-base-pair deletion. We have also tested this hypothesis by using Y. pestis infection in mice and, in addition, we have done phagocytosis experiments with macrophages from wild-type and Ccr5-deficient mice. Although, like Mecsas et al., we did not see any difference in the survival of the two groups of mice, we did find that there was a significantly reduced uptake of Y. pestis by Ccr5-deficient macrophages in vitro. Our results indicate that the role of Ccr5 in Y. pestis infection may therefore be more complex than previously thought. 相似文献
67.
Mutations in SOX2 cause anophthalmia 总被引:12,自引:0,他引:12
Fantes J Ragge NK Lynch SA McGill NI Collin JR Howard-Peebles PN Hayward C Vivian AJ Williamson K van Heyningen V FitzPatrick DR 《Nature genetics》2003,33(4):461-463
A submicroscopic deletion containing SOX2 was identified at the 3q breakpoint in a child with t(3;11)(q26.3;p11.2) associated with bilateral anophthalmia. Subsequent SOX2 mutation analysis identified de novo truncating mutations of SOX2 in 4 of 35 (11%) individuals with anophthalmia. Both eyes were affected in all cases with an identified mutation. 相似文献
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Correlation of optical activity with polysaccharide conformation 总被引:3,自引:0,他引:3
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