Carcinostatic activity of a thiazolidinonylidene-hydrazonothiazolidinone derivative against DMBA-induced mammary carcinomata in female Sprague-Dawley rats

Zusammenfassung 5-Methyl-3-(2-methylallyl)-2-[(3-methyl-4-oxo-2-thiazolidinyliden)-hydrazono]-4-thiazolidinon erwies sich bei guter therapeutischer Breite als stark karzinostatisch wirksam bei DMBA-induzierten Mamma-Karzinomen weiblicher Sprague-Dawley Ratten. Eine geringere chemotherapeutische Wirkung fand sich auch bei Walker CaSa 256, DMBA-induzierten Hautkarzinomen und Ehrlich Ascites Karzinom.     

De la réaction mitotique de l'épiderme de la tétine de cobaye à la suite d'applications répétées de diverses substances

Summary (1) The majority of substances tested produced a weaker mitotic reaction of the epidermis of the guinea pig nipple after 3 applications (24 h intervals) of the same substance than after a single application.(2) This decrease in the ability of the epidermic cells to be divided has to be attributed, it seems, to a habit-forming processus and not to an exhaustion of the cells; indeed after two applications of geraniol, the application of a substance of different nature, Hormoestrol, produced in the nipple epidermis a mitotic flare up as intense as that obtained in the epidermis of a nipple not previously treated.(3) Aldehyde C₉ alone, among the substances tested, does not produce a decrease of epidermic mitoses after three applications but induces cellular alterations.