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L. A. Mitscher W. W. Andres W. McCrae 《Cellular and molecular life sciences : CMLS》1964,20(5):258-259
Zusammenfassung Die Struktur des ausStreptomyces rubreticulae isolierten neuen Isocumarins, Reticulol, ist als 3-Methyl-6,8-dihydroxy-7-methoxyisocumarin ermittelt worden. 相似文献
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E. L. Patterson W. W. Andres R. E. Hartman 《Cellular and molecular life sciences : CMLS》1964,20(5):256-257
Zusammenfassung Conessin wurde mikrobiologisch durchCunninghamella echinulata in zwei Produkte zerlegt, welche in reiner Form isoliert und mit 7-Hydroxyconessin und 7-Hydroxyconessin identifiziert werden konnten. 相似文献
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Thorgeirsson TE Geller F Sulem P Rafnar T Wiste A Magnusson KP Manolescu A Thorleifsson G Stefansson H Ingason A Stacey SN Bergthorsson JT Thorlacius S Gudmundsson J Jonsson T Jakobsdottir M Saemundsdottir J Olafsdottir O Gudmundsson LJ Bjornsdottir G Kristjansson K Skuladottir H Isaksson HJ Gudbjartsson T Jones GT Mueller T Gottsäter A Flex A Aben KK de Vegt F Mulders PF Isla D Vidal MJ Asin L Saez B Murillo L Blondal T Kolbeinsson H Stefansson JG Hansdottir I Runarsdottir V Pola R Lindblad B 《Nature》2008,452(7187):638-642
Smoking is a leading cause of preventable death, causing about 5 million premature deaths worldwide each year. Evidence for genetic influence on smoking behaviour and nicotine dependence (ND) has prompted a search for susceptibility genes. Furthermore, assessing the impact of sequence variants on smoking-related diseases is important to public health. Smoking is the major risk factor for lung cancer (LC) and is one of the main risk factors for peripheral arterial disease (PAD). Here we identify a common variant in the nicotinic acetylcholine receptor gene cluster on chromosome 15q24 with an effect on smoking quantity, ND and the risk of two smoking-related diseases in populations of European descent. The variant has an effect on the number of cigarettes smoked per day in our sample of smokers. The same variant was associated with ND in a previous genome-wide association study that used low-quantity smokers as controls, and with a similar approach we observe a highly significant association with ND. A comparison of cases of LC and PAD with population controls each showed that the variant confers risk of LC and PAD. The findings provide a case study of a gene-environment interaction, highlighting the role of nicotine addiction in the pathology of other serious diseases. 相似文献
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L. A. Mitscher M. P. Kunstmann J. H. Martin W. W. Andres R. H. Evans Jr. K. J. Sax E. L. Patterson 《Cellular and molecular life sciences : CMLS》1967,23(10):796-796
Zusammenfassung Es wird gezeigt, dass Diketopiperazine, insbesonderel-Leucyl-l-prolin-anhydrid, eher aus dem Medium stammende Artefakte als echte mikrobielle Stoffwechselprodukte sind. 相似文献
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L. A. Mitscher W. W. Andres G. O. Morton E. L. Patterson 《Cellular and molecular life sciences : CMLS》1968,24(2):133-134
Zusammenfassung In der vorliegenden Arbeit werden mikrobiologische Umwandlungen von mehreren 6, 14-endo-Äthenotetrahydrothebain Alkaloiden beschrieben. Mit Hilfe von verschiedenen Mikroorganismen konnten stereospezifische Reduktionen undN-Desalkylierungen ausgeführt werden. 相似文献
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H. H. Günthard T. Gäumann G. Andres 《Cellular and molecular life sciences : CMLS》1960,16(12):567-568
Ohne Zusammenfassung 相似文献
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Strässer K Masuda S Mason P Pfannstiel J Oppizzi M Rodriguez-Navarro S Rondón AG Aguilera A Struhl K Reed R Hurt E 《Nature》2002,417(6886):304-308
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Ionotropic glutamate receptors (iGluRs) mediate most excitatory synaptic signalling between neurons. Binding of the neurotransmitter glutamate causes a conformational change in these receptors that gates open a transmembrane pore through which ions can pass. The gating of iGluRs is crucially dependent on a conserved amino acid that was first identified in the 'lurcher' ataxic mouse. Through a screen for modifiers of iGluR function in a transgenic strain of Caenorhabditis elegans expressing a GLR-1 subunit containing the lurcher mutation, we identify suppressor of lurcher (sol-1). This gene encodes a transmembrane protein that is predicted to contain four extracellular beta-barrel-forming domains known as CUB domains. SOL-1 and GLR-1 are colocalized at the cell surface and can be co-immunoprecipitated. By recording from neurons expressing GLR-1, we show that SOL-1 is an accessory protein that is selectively required for glutamate-gated currents. We propose that SOL-1 participates in the gating of non-NMDA (N-methyl-D-aspartate) iGluRs, thereby providing a previously unknown mechanism of regulation for this important class of neurotransmitter receptor. 相似文献