载带姜黄素的卵磷脂/果胶锌凝胶球的性能

采用滴制法制备载带姜黄素的卵磷脂/果胶锌凝胶球,以粒径、粒质量、载药量、包封率以及体外释药性能为评价指标,讨论工艺参数对评价指标的影响.实验制备的载带姜黄素的卵磷脂/果胶锌凝胶球成球均匀,平均粒径1.34~1.59,mm,平均粒质量1.74~3.45,mg.当卵磷脂与果胶的质量比为5∶4、药胶质量比为16∶20、氯化锌质量浓度为70,g/L、果胶质量浓度40,g/L、NaOH质量浓度为30,g/L时,载药量为18.03%,包封率为85.81%,模拟小肠液中8,h累积释药率为1.64%,再进入模拟结肠环境36,h累积释药率为68.72%.结果表明,卵磷脂的加入改善了果胶锌凝胶球对姜黄素的载带效果以及缓释效果.     

NIQGA改进及基于可变角距离的新型量子进化算法

为了提高量子进化算法的执行效率,在NIQGA算法基础上,通过改进△θi和S(αi,βi)参数表提出了一种改进算法INIQGA.又通过引入量子比特间角距离定义,提出了一种基于可变角距离旋转的量子进化算法QEA-VAR,该算法采用旋转门操作进行种群进化时,依据当前染色体中量子比特|φ〉i与最优解对应基态| 0〉或| 1〉的...     

虚拟环境中水文数据时空展布和三维等值线生成算法研究

为实现海量数据的信息快速挖掘和直观表达,提出了基于数字流域仿真平台的水文数据三维可视化方法.该方法利用顾及地形特征生成的流域离散点作为数字流域仿真平台与观测数据和分布式水文模拟结果集成的基础;研究了流域水文数据时空展布和三维等值线生成算法与分区透明度和颜色值相结合增加视觉敏感性来虚拟表达水文时空信息;并引入计算机动画技术实现水文数据时空演变过程.最后将以上算法与数字流域仿真平台集成应用于长江上游降雨过程的动态三维可视化系统的构建,取得了良好效果.     

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

Amyotrophic lateral sclerosis (ALS) is a paralytic and usually fatal disorder caused by motor-neuron degeneration in the brain and spinal cord. Most cases of ALS are sporadic but about 5-10% are familial. Mutations in superoxide dismutase 1 (SOD1), TAR DNA-binding protein (TARDBP, also known as TDP43) and fused in sarcoma (FUS, also known as translocated in liposarcoma (TLS)) account for approximately 30% of classic familial ALS. Mutations in several other genes have also been reported as rare causes of ALS or ALS-like syndromes. The causes of the remaining cases of familial ALS and of the vast majority of sporadic ALS are unknown. Despite extensive studies of previously identified ALS-causing genes, the pathogenic mechanism underlying motor-neuron degeneration in ALS remains largely obscure. Dementia, usually of the frontotemporal lobar type, may occur in some ALS cases. It is unclear whether ALS and dementia share common aetiology and pathogenesis in ALS/dementia. Here we show that mutations in UBQLN2, which encodes the ubiquitin-like protein ubiquilin?2, cause dominantly inherited, chromosome-X-linked ALS and ALS/dementia. We describe novel ubiquilin?2 pathology in the spinal cords of ALS cases and in the brains of ALS/dementia cases with or without UBQLN2 mutations. Ubiquilin?2 is a member of the ubiquilin family, which regulates the degradation of ubiquitinated proteins. Functional analysis showed that mutations in UBQLN2 lead to an impairment of protein degradation. Therefore, our findings link abnormalities in ubiquilin?2 to defects in the protein degradation pathway, abnormal protein aggregation and neurodegeneration, indicating a common pathogenic mechanism that can be exploited for therapeutic intervention.     

灯盏花素对家兔左心缺血再灌注后肺组织肿瘤坏死因子-α表达的影响

目的:探讨灯盏花素对左心缺血再灌注后肺组织肿瘤坏死因子α(TNF-α)表达的影响.方法:60只成年健康新西兰家兔随机分为模型组和治疗组.两组家兔均结扎及再通左冠状动脉前降支复制左心缺血-再灌注模型,治疗组在缺血后10min经静脉给予灯盏花素注射液10mg·kg-1.在缺血30min、再灌注20min、40min 3个时间点,取外周血和支气管肺泡灌洗液(BALF),ELISA法检测TNF-α表达水平;取肺组织标本,免疫组织化学法检测肺组织中TNF-α的表达,HE染色和电镜检测肺组织形态学改变.结果:模型组可见I型和II型肺泡上皮变性,呈急性炎症损伤改变,治疗组损伤明显减轻.外周血、BALF和肺组织细胞中TNF-α表达均低于模型组(P<0.05).结论:灯盏花素可通过减少TNF-α的表达,减轻因左心缺血再灌注而导致的急性肺损伤.     

Extraction of Sea-state parameters with an X-band radar

Ocean wave spectrum and surface currents can be determined from a series of spatial wave images recorded by an X-band marine radar. In the absence of a surface current, the three-dimensional spectral energy found by using the series of images will be confined to a trajectory defined by the still water dispersion relationship. The presence of a surface current will make the three-dimensional spectral energy show a corresponding Doppler shill which may determine the current using the least squares method and obtain the directional wave spectrum. On the basis of conventional wave spectrum and directional function, the paper emulates a series of X-band radar images considering shadowing modulation and simulates numerically the threedimensional image spectrum both with and without a surface current, calculates the current velocity by virtue of the Doppler shift, and obtains the two-dimensional image spectrum. Finally the paper analyzes measured wave level elevation-a function of time t to obtain one-dimensional image spectrum, and the data comes from an X-band radar in McMaster University.     

社交网络在高校图书馆信息服务中的应用模式探讨

介绍了网络发展的状况和社交网络的定义,阐述了高校图书馆引入社交网络来提高信息服务质量的必要性,探讨了社交网络在高校图书馆的应用模式及其主要特点,提出了社交网络应用于高校图书馆信息服务时应注意的问题。     

甘肃北山地区三维地质建模方法对比研究

三维地质建模是可视化表达地下地质体的空间分布和有效分析空间数据的重要方法.甘肃北山区域面积大而且地质构造较为复杂,是我国高放废物地质处置预选区之一.本文在综述国内外地质建模工具和特点的基础上,基于甘肃北山地区地质和水文地质条件,采用ArcScene、GoCAD、Petrel以及DHI-WASY公司的FEFLOW Explorer软件构建了三维地质模型,展示了高程信息、断层分布、渗透系数的空间变化,同时将各软件建立的地质模型进行对比,发现GoCAD和Petrel建立的三维地质模型较优.建立的地质模型,其结果将有助于快速分析甘肃北山高放废物地质处置效果.     

分数阶黏弹性模型在饱和软土与单桩相互作用中的应用

引入基于分数阶导数的Merchant模型,以描述饱和软土的黏弹性特征,并通过积分变换推导出变换域内的应力-应变关系;根据弹性-黏弹性对应原理,得到横观各向同性分数阶黏弹性饱和软土地基的解答,并将其作为地基边界元解的核函数;基于轴向受力的2节点桩单元的单元刚度矩阵,构建单桩的有限元解;将地基的边界元解和桩的有限元解进行耦合,以求解地基与单桩的相互作用问题;随后,设计算例验证本文理论的正确性,并对分数阶次对桩-土相互作用的影响进行分析。     

高校智慧图书馆GRSI建设理念模型研究

党的十九大报告提出"智慧社会",指引了高校智慧图书馆建设方向.以智慧社会为切入点,探讨智慧图书馆建设模型,以期为高校智慧图书馆建设提供理论借鉴.运用文献调查法收集、分析国内当前智慧图书馆在概念、技术方法、政策、服务、治理以及用户、馆员等方面的研究现状,提出了"治理(G)、资源(R)、服务(S)、创新(I)"为一体的GRSI智慧图书馆建设理念模型.模型中4项核心要素处在一个相互促进的循环中,而这个循环在外部技术、理论及政策环境的作用下进行着以满足用户需求为目的的知识与智慧产出.