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31.
Weinberg S. R. Bakarich A. C. Ledney G. D. McGarry M. P. MacVittie T. J. 《Cellular and molecular life sciences : CMLS》1983,39(8):864-866
Cellular and Molecular Life Sciences - Hemopoietic perturbations were observed in gravid beagles subjected to whole-body ionizing radiation during midpregnancy followed by the additional trauma of... 相似文献
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A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma 总被引:216,自引:0,他引:216
S H Friend R Bernards S Rogelj R A Weinberg J M Rapaport D M Albert T P Dryja 《Nature》1986,323(6089):643-646
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Mechanism of activation of a human oncogene 总被引:215,自引:0,他引:215
C J Tabin S M Bradley C I Bargmann R A Weinberg A G Papageorge E M Scolnick R Dhar D R Lowy E H Chang 《Nature》1982,300(5888):143-149
The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. Instead, it affects the structure of the oncogene-encoded protein. 相似文献
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Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation 总被引:117,自引:0,他引:117
The protein p53 is highly expressed in a large variety of transformed cell types originating from diverse species. These include cells transformed by Simian virus 40 (SV40), adenovirus and Abelson virus, as well as a variety of chemically transformed cells. Substantial amounts of p53 are also present in certain non-transformed cells, for example, some embryonic tissues. The protein may be localized in different cellular compartments in normal and transformed cells. The strong correlation between tumorigenicity and high levels of p53 suggests an important role of p53 in tumorigenesis. We report here experiments in which we have co-transfected the murine cellular gene encoding for p53 with a ras gene into primary rat embryo fibroblasts. Our results indicate that the p53-encoding gene can play a causal role in the conversion of normal fibroblasts into tumorigenic cells. 相似文献
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't Hooft G Susskind L Witten E Fukugita M Randall L Smolin L Stachel J Rovelli C Ellis G Weinberg S Penrose R 《Nature》2005,433(7023):257-259
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