"三个代表"重要思想如何进"两课"课堂

“两课”课堂是向大学生进行“三个代表”重要思想教育的重要途径,我们不仅要使学生了解“三个代表”重要思想的科学内涵,而且要使学生深入领会其精神实质。     

吉安市农村群众体育健身点的现状调查与分析

主要采用调查法和文献资料法对江西省吉安市农村群众体育健身点的现状进行调查分析,提出了一些发展农村群众体育的建议,为更好地组织实施全民健身计划提供了参考依据.     

试论隐性城市化——江阴农村城市化道路分析

本文通过对江阴农村的实地考察,提出了隐性城市化的概念,认为农村城市化与居民点集中没有必然的联系,农村城市化的根本目的是要提高农村人民的生活水平和消灭城乡差别,在此基础上,进而对江阴农村城市化的发展方向和目前应该采取的措施作了初步探讨,在一定程度上有助于揭示我国发达地区农村城市化的某些规律和特点,对我国发达地区制定农村发展政策有一定参考价值。     

新型超导体MgB2电子结构与成键性质的第一性原理研究

对最新发现MgB2 超导体 (Tc≈ 39K)的电子结构及化学成键从能带结构、电子态密度DOS、价电子电荷密度分布等几个方面 ,采用LMTO方法进行了第一性原理研究 .同时对相关的同族二硼化物BeB2 、CaB2 电子性质的相似及差异给与阐述和比较 ,报告了SmB2 ,UB2 和LuB2 态密度的计算结果 ,并对它们的超导电性进行讨论与推测 .     

Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology

Neurofibromatosis type 2 is an autosomal dominant disorder characterized by tumors, predominantly schwannomas, in the nervous system. It is caused by mutations in the gene NF2, encoding the growth regulator schwannomin (also known as merlin). Mutations occur throughout the 17-exon gene, with most resulting in protein truncation and undetectable amounts of schwannomin protein. Pathogenic mutations that result in production of defective schwannomin include in-frame deletions of exon 2 and three independent missense mutations within this same exon. Mice with conditional deletion of exon 2 in Schwann cells develop schwannomas, which confirms the crucial nature of exon 2 for growth control. Here we report that the molecular adaptor paxillin binds directly to schwannomin at residues 50-70, which are encoded by exon 2. This interaction mediates the membrane localization of schwannomin to the plasma membrane, where it associates with beta 1 integrin and erbB2. It defines a pathogenic mechanism for the development of NF2 in humans with mutations in exon 2 of NF2.     

Coherent emission of light by thermal sources

A thermal light-emitting source, such as a black body or the incandescent filament of a light bulb, is often presented as a typical example of an incoherent source and is in marked contrast to a laser. Whereas a laser is highly monochromatic and very directional, a thermal source has a broad spectrum and is usually quasi-isotropic. However, as is the case with many systems, different behaviour can be expected on a microscopic scale. It has been shown recently that the field emitted by a thermal source made of a polar material is enhanced by more than four orders of magnitude and is partially coherent at a distance of the order of 10 to 100nm. Here we demonstrate that by introducing a periodic microstructure into such a polar material (SiC) a thermal infrared source can be fabricated that is coherent over large distances (many wavelengths) and radiates in well defined directions. Narrow angular emission lobes similar to antenna lobes are observed and the emission spectra of the source depends on the observation angle--the so-called Wolf effect. The origin of the coherent emission lies in the diffraction of surface-phonon polaritons by the grating.     

液压系统自动建模与仿真软件的研制

基于液压大系统“灰箱”建模原理与方法 ,研究开发了适用于液压大系统的自动建模与仿真软件。本文重点介绍了“灰箱”建模法的特点并应用研究软件对 15KJ电液锤液压系统进行了仿真计算     

授时历议中的仲康日食记录研究

“授时历议”见于《元史·历志》,是一篇用以阐述《授时历》（元代郭守敬等编制,行用于ＡＤ１２８１—１６４４）博大精深的长篇论文．通过对其中“仲康日食”记录的研究得出：１）“仲康日食”是一个与古代天文家推步合验的事件;２）《授时历》能求解出大部分“仲康日食”的现有结果;３）公元前２１２８年１０月１３日是僧一行（６８３—７２７）和郭守敬（１２３１—１３１６）推步“仲康日食”发生的日期,但尚未得到现代计算的认同;４）公元前２１２８年为仲康五年,只是古代的一个年代学结论．     

一种新型介质透镜的优化设计方法

利用几何光学法设计优化了一种新型的用于紧缩场测试的介质透镜。以发射点到接收点的光程差为目标函数 ,对透镜的照亮面轮廓进行优化 ,得出其函数表达式 ,使得在± 2 0°扫描角范围内 ,被测系统接收到的为近似的平面波。最后将有透镜校正与没加透镜的情况进行计算比较 ,可以看出校正效果明显。     

An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

Hepatitis C virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at risk of developing significant morbidity and mortality. Current interferon-based therapies are suboptimal especially in patients infected with HCV genotype 1, and they are poorly tolerated, highlighting the unmet medical need for new therapeutics. The HCV-encoded NS3 protease is essential for viral replication and has long been considered an attractive target for therapeutic intervention in HCV-infected patients. Here we identify a class of specific and potent NS3 protease inhibitors and report the evaluation of BILN 2061, a small molecule inhibitor biologically available through oral ingestion and the first of its class in human trials. Administration of BILN 2061 to patients infected with HCV genotype 1 for 2 days resulted in an impressive reduction of HCV RNA plasma levels, and established proof-of-concept in humans for an HCV NS3 protease inhibitor. Our results further illustrate the potential of the viral-enzyme-targeted drug discovery approach for the development of new HCV therapeutics.