糖尿病血瘀证与内皮素和心钠素的关系研究

目的 :探讨内皮素 (ET)、心钠素 (ANP)与糖尿病 (DM)血瘀证的关系。方法 :检测 44例 DM血瘀证患者和 2 0例正常对照组的 ET和 ANP含量。结果 :血瘀证组 ET、ANP含量明显高于正常对照组。结论 :ET、ANP共同参与了 DM血瘀证的病理过程     

Preparing Ca-P coating on biodegradable magnesium alloy by hydrothermal method: In vitro degradation behavior

Magnesium alloys are potentially attractive biodegradable materials.However,their rapid corrosion rate limits their biomedical application.To slow down the rate of biodegradation,a protective calcium-phosphate coating was formed on a magnesium alloy substrate by a hydrothermal method.Scanning electron microscope results showed that the coating consisted of two layers with different crystalline characteristics.The loose outer layer showed a prism-like crystal structure,while the compact inner layer is a dense ultra-fine regular di-pyramid-like structure with an average grain dimension of ～200 nm.The compositions of the inner layer and outer layer were calcium-deficient hydroxyapatite (Ca-def HA) and dicalcium phosphate (DCPa),respectively.The coating adhered well to the substrate with a thickness of about 15 m.Immersion in Hank’s solution indicated that the coating could significantly improve the degradation properties of magnesium alloy.The pH of the solution containing the coated samples increased much more slowly than the untreated control.After 8 d immersion,the uncoated sample had corroded seriously while the coated sample was much less corroded.The Ca/P atom ratio in both the layers of the coating increased and the coating was still protecting the substrate.The two layers of the coating corroded differently because of differences in solubility.The outer layer was more severely attacked and many holes were formed on the surface,the inner layer suffered less attack.In addition,a growth of precipitate on the inner layer was observed,indicating that surface bioactivity was improved by the coating.Thus,magnesium alloys coated with a Ca-P coating prepared by a hydrothermal method are promising candidate biodegradable biomaterials,and further investigation of in vivo degradation behavior is suggested.     

Measurement of laminar burning velocities of iso-butanol-air mixtures

The laminar burning velocity of iso-butanol-air mixtures was measured under different initial pressures, initial temperatures and equivalence ratios using high-speed schlieren photography and outwardly propagation flame in a constant volume combustion bomb. Based on the analysis of stretched flame propagation speed and stretch rate, the laminar burning velocities and Markstein lengths of iso-butanol-air flames are obtained. In accordance, with photos of flame, an analysis of flame stability and the influencing factors is carried out. The results show that the laminar burning velocity is decreased with the increase of initial pressure and is increased with the increase of initial temperature. The maximum value of laminar burning velocity is presented at the equivalence ratio of 1.2. The Markstein length is decreased with the increase of equivalence ratio. For specified equivalence ratio, the Markstein length is decreased with the increase of initial temperature and initial pressure. Thus, the flame instability is increased with the increase of equivalence ratio, initial temperature and initial pressure.     

冲击荷载下高速公路护栏的实验研究和优化分析

通过对冲击作用下的高速公路护栏进行实验研究和有限元分析,探讨了高速公路护栏的动力特征．发现随着冲击位移的增加,冲击速度几乎呈线性下降,冲击加速度很快减少到一个极小值,而能量吸收阶段中前阶段的吸收速度比后阶段快．文中还根据护栏的能量吸收特征和初始冲击力对护栏结构进行了优化设计．结果表明,在所选的各种高速公路缩比护栏模型中,1．3mm厚、0．665m单跨长的三波形梁是最优波形护栏结构．     

盾构隧道衬砌结构小角度斜穿地裂缝的破坏机理

从西安地铁1 #线工程背景和西安地裂缝地质环境出发,根据相似理论设计了盾构隧道管片衬砌结构30°斜穿地裂缝的物理模型试验管片混凝土应变、纵向和环向螺栓应变、结构接触土压力外围土压力、结构内部收敛位移、模型顶表面土体变形以及宏观变形破坏现象表明:盾构隧道管片衬砌结构30°斜穿地裂缝的变形破坏模式为剪切变形为主,局部有扭转变形;结构破坏范围为上盘1.25D,下盘0.75D(D为管片环外径);管片衬砌结构变形破坏不对称,管片环向处于偏压状态;环缝拱底位错量大于拱顶和拱腰,拱底最大位错量达40 mm(0.033D),模型难以适用地裂缝错动变形20 cm(0.1667 D),盾构管片衬砌结构不适用于地裂缝活动强烈的地质环境     

动力学参数微机辅助测量系统

文中介绍了一套对动力学参数测定的微机辅助测量和数据处理系统,可用于丙酮溴化反应,乙酸乙脂皂化反应和甲酸盐氧化反应等多种动力学参数测定实验。     

仿青蛙跳跃机器人的动力学分析

设计了一种仿青蛙跳跃机器人,该机器人以跳跃能力突出的青蛙为原型设计机械结构,以气动人工肌肉作为其驱动器.这样使得整部机器人的结构接近生物青蛙,具有较高的隐蔽性,能够满足军事侦察等任务的要求.但是,由于仿生结构的复杂性给运动学和动力学的分析带来了困难.运用拉格朗日法对机器人在不同的跳跃阶段进行动力学分析,得出每个跳跃阶段的动力学方程.并利用AD-AMS和Matlab联合仿真的方法对得到的动力学方程进行验证,其结果说明了分析的正确性.这为后续研究工作奠定基础.     

自体和异体CIK细胞联合树突状细胞治疗原发性肝癌研究

为对癌症患者采用个体化治疗,用患者自体、同种异体外周血进行细胞因子诱导的杀伤细胞(Cytokine Induced Killer,CIK)及树突状细胞(Dendritic Cell,DC)扩增,并应用流式细胞术检测其CIK、DC-CIK表型,然后采取静脉回输、皮下淋巴结注射和肝动脉灌注多种方法,对原发性肝癌进行自体和异体的CIK细胞联合DC细胞治疗。结果显示:患者免疫功能提高,生活质量改善。为该类患者提供了一种有效的免疫治疗手段。     

丹参提取物对氧化衰老模型小鼠的免疫保护作用

采用小鼠氧化衰老模型探讨丹参提取物的免疫保护作用及抗氧化作用 .用小鼠脾脏淋巴细胞增殖试验检测免疫细胞的功能状态 ;用免疫组化法和HE染色观察胸腺的氧化情况及形态学变化 ;用流式细胞仪检测细胞表面CD2 8分子及其他分子的变化 ,来探讨免疫分子的变化情况 .结果表明丹参提取物能明显恢复由氧化应激造成的免疫功能低下状态 .淋巴细胞增殖功能得到了明显改善 .胸腺内核酸氧化产物 8-OHdG染色阳性细胞明显减少 ,胸腺皮质恢复良好 .免疫细胞表面CD2 8分子明显增加 ,CD4阳性细胞也明显增多     

基于量化指标分析的软件质量度量方法

使用定量的软件质量度量能够为质量管理人员的决策提供数据的基础，并减少定性评价或者主观评价的片面性。本文基于ISO/IEC9126软件质量标准，在分析软件质量度量的量化指标的基础上，进行了软件质量度量方法的研究，完善了软件质量综合特性和定量指标的度量模型。