Luminal alkalinization by guinea-pig cecum in vitro,an electro-neutral process

Summary Guinea-pig cecum was found to alkalinize its mucosal media in vitro at a chemical equivalents rate greater than the short circuit current (I_SC). Alkalinization was inhibited by conditions which did not affect I_SC and by low mucosal Na suggesting an electro-neutral process, dependent on Na.This study was supported in part by the National Science Foundation Grant BMS 74-08901. The authors appreciate the insight and encouragement of Dr Michael J. Jackson expressed in numerous conversations.     

Forces and causes in Kant’s early pre-Critical writings

This paper considers Kant’s conception of force and causality in his early pre-Critical writings, arguing that this conception is best understood by way of contrast with his immediate predecessors, such as Christian Wolff, Alexander Baumgarten, Georg Friedrich Meier, Martin Knutzen, and Christian August Crusius, and in terms of the scientific context of natural philosophy at the time. Accordingly, in the True estimation Kant conceives of force in terms of activity rather than in terms of specific effects, such as motion (as unnamed Wolffians had done). Kant’s explicit arguments in the Nova dilucidatio for physical influx (in the guise of the principle of succession) are directed primarily against the conception of grounds and existence held by Wolff, Baumgarten, and Meier, and only secondarily against Leibniz (by asserting the priority of bodies over mind rather than vice versa). Finally, Kant’s reconciliation of the infinite divisibility of space and the unity of monads in the Physical monadology is designed to respond to objections that could be raised naturally by Wolff and Baumgarten.     

A polymorphic DNA marker genetically linked to Huntington's disease

Family studies show that the Huntington's disease gene is linked to a polymorphic DNA marker that maps to human chromosome 4. The chromosomal localization of the Huntington's disease gene is the first step in using recombinant DNA technology to identify the primary genetic defect in this disorder.     

Selective antagonism by Mg2+ of amino acid-induced depolarization of spinal neurones

Summary In the isolated frog or rat spinal cord, low concentrations of Mg²⁺ (0.5–1.00 mM) markedly depress, in a substantially Ca²⁺-independent manner, ventral root depolarizations produced by dorsal root stimulation and by certain amino acids (e. g. N-methyl-D-aspartate and L-homocysteate) but do not depress depolarizations produced by other excitatory amino acids (e. g. kainate and quisqualate). L-Aspartate-induced depolarizations are more sensitive to Mg²⁺ then are L-glutamate-induced depolarizations.Acknowledgment. We thank D. J. Oakes for skilled technica assistance. This work was supported by the Medical Research Council.