全文获取类型
收费全文 | 188篇 |
免费 | 1篇 |
国内免费 | 1篇 |
专业分类
系统科学 | 2篇 |
丛书文集 | 2篇 |
教育与普及 | 1篇 |
现状及发展 | 29篇 |
研究方法 | 19篇 |
综合类 | 132篇 |
自然研究 | 5篇 |
出版年
2021年 | 1篇 |
2020年 | 1篇 |
2019年 | 1篇 |
2017年 | 3篇 |
2016年 | 2篇 |
2015年 | 2篇 |
2014年 | 2篇 |
2013年 | 1篇 |
2012年 | 12篇 |
2011年 | 18篇 |
2010年 | 4篇 |
2009年 | 10篇 |
2008年 | 7篇 |
2007年 | 10篇 |
2006年 | 9篇 |
2005年 | 10篇 |
2004年 | 7篇 |
2003年 | 6篇 |
2002年 | 11篇 |
2001年 | 5篇 |
2000年 | 9篇 |
1999年 | 5篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1975年 | 3篇 |
1974年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1970年 | 4篇 |
1969年 | 4篇 |
1967年 | 3篇 |
1966年 | 3篇 |
1965年 | 3篇 |
排序方式: 共有190条查询结果,搜索用时 15 毫秒
121.
122.
The Solar System's outer planets that contain hydrogen gas all host systems of multiple moons, which notably each contain a similar fraction of their respective planet's mass (approximately 10(-4)). This mass fraction is two to three orders of magnitude smaller than that of the largest satellites of the solid planets (such as the Earth's Moon), and its common value for gas planets has been puzzling. Here we model satellite growth and loss as a forming giant planet accumulates gas and rock-ice solids from solar orbit. We find that the mass fraction of its satellite system is regulated to approximately 10(-4) by a balance of two competing processes: the supply of inflowing material to the satellites, and satellite loss through orbital decay driven by the gas. We show that the overall properties of the satellite systems of Jupiter, Saturn and Uranus arise naturally, and suggest that similar processes could limit the largest moons of extrasolar Jupiter-mass planets to Moon-to-Mars size. 相似文献
123.
Zheng J Umikawa M Cui C Li J Chen X Zhang C Huynh H Hyunh H Kang X Silvany R Wan X Ye J Cantó AP Chen SH Wang HY Ward ES Zhang CC 《Nature》2012,485(7400):656-660
How environmental cues regulate adult stem cell and cancer cell activity through surface receptors is poorly understood. Angiopoietin-like proteins (ANGPTLs), a family of seven secreted glycoproteins, are known to support the activity of haematopoietic stem cells (HSCs) in vitro and in vivo. ANGPTLs also have important roles in lipid metabolism, angiogenesis and inflammation, but were considered 'orphan ligands' because no receptors were identified. Here we show that the immune-inhibitory receptor human leukocyte immunoglobulin-like receptor B2 (LILRB2) and its mouse orthologue paired immunoglobulin-like receptor (PIRB) are receptors for several ANGPTLs. LILRB2 and PIRB are expressed on human and mouse HSCs, respectively, and the binding of ANGPTLs to these receptors supported ex vivo expansion of HSCs. In mouse transplantation acute myeloid leukaemia models, a deficiency in intracellular signalling of PIRB resulted in increased differentiation of leukaemia cells, revealing that PIRB supports leukaemia development. Our study indicates an unexpected functional significance of classical immune-inhibitory receptors in maintenance of stemness of normal adult stem cells and in support of cancer development. 相似文献
124.
125.
126.
127.
128.
Lindblad-Toh K Garber M Zuk O Lin MF Parker BJ Washietl S Kheradpour P Ernst J Jordan G Mauceli E Ward LD Lowe CB Holloway AK Clamp M Gnerre S Alföldi J Beal K Chang J Clawson H Cuff J Di Palma F Fitzgerald S Flicek P Guttman M Hubisz MJ Jaffe DB Jungreis I Kent WJ Kostka D Lara M Martins AL Massingham T Moltke I Raney BJ Rasmussen MD Robinson J Stark A Vilella AJ Wen J Xie X Zody MC;Broad Institute Sequencing Platform Whole Genome Assembly Team Baldwin J Bloom T Chin CW Heiman D Nicol R 《Nature》2011,478(7370):476-482
The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at least 5.5% of the human genome has undergone purifying selection, and locate constrained elements covering ~4.2% of the genome. We use evolutionary signatures and comparisons with experimental data sets to suggest candidate functions for ~60% of constrained bases. These elements reveal a small number of new coding exons, candidate stop codon readthrough events and over 10,000 regions of overlapping synonymous constraint within protein-coding exons. We find 220 candidate RNA structural families, and nearly a million elements overlapping potential promoter, enhancer and insulator regions. We report specific amino acid residues that have undergone positive selection, 280,000 non-coding elements exapted from mobile elements and more than 1,000 primate- and human-accelerated elements. Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease. 相似文献
129.
克隆了酿酒酵母(Saccharomyces cerevisiae) 中的3-磷酸甘油脱氢酶和3-磷酸甘油酯酶基因,通过融合PCR构建了双基因共表达载体,将酵母细胞内应答渗透压变化的甘油合成途径引入大肠杆菌(Escherichia coli)。以葡萄糖为底物对重组大肠杆菌进行摇瓶发酵培养,该重组菌的甘油产量为1g/L。渗透压胁迫测试证明该重组菌的耐渗透压性能较出发菌株有明显提高。 相似文献
130.
沙平 《厦门理工学院学报》2000,(2)
科学研究离不开分类 ,本文通过对汉语中最基本的语法单位语素的分类研究 ,不仅准确地定义了汉语虚词 ,而且理清了汉语语法研究中长期混淆不清的两个概念———汉语虚语与附加成分的界限 相似文献