Exocytotic fusion is activated by Rab3a peptides.

Studies of intracellular traffic in yeast and mammalian systems have implicated members of the Rab family of small GTP-binding proteins as regulators of membrane fusion. We have used the patch clamp technique to measure exocytotic fusion events directly and investigate the role of GTP-binding proteins in regulating exocytosis in mast cells. Intracellular perfusion of mast cells with GTP-gamma S is sufficient to trigger complete exocytotic degranulation in the absence of other intracellular messengers. Here we show that GTP is a potent inhibitor of GTP-gamma S-induced degranulation, indicating that sustained activation of a GTP-binding protein is sufficient for membrane fusion. We have found that synthetic oligopeptides, corresponding to part of the effector domain of Rab3a, stimulate complete exocytotic degranulation, similar to that induced by GTP-gamma S. The response is selective for Rab3a sequence and is strictly dependent on Mg2+ and ATP. This suggests that sustained activation of a Rab3 protein causes exocytotic fusion. The peptide response can be accelerated by GDP-beta S, suggesting that Rab3a peptides compete with endogenous Rab3 proteins for a binding site on a target effector protein, which causes fusion on activation.     

Zn^2＋在电解还原铕（Ⅲ）过程中的催化行为研究

本文报道微量Zn~(2+)在电解还原铕(Ⅲ)离子过程中的催化作用,研究结果表明:当阴极中含Zn~(2+)时,铕(Ⅲ)离子将缩短到达定量还原的时间,用循环伏安法监控电极过程的结果表明:电极过程是准一级的催化过程。     

岩芯筒压入地层的塑性力学问题

摘要首先从库仑定律出发导出了地层介质塑性流动条件。其结果类似于一般塑性力学中的Tresca,Mises条件。其次列出了轴对称地层塑性流动的微分方程组,并推出了其简化近似方程。最后提出了简化方程的特征线解法,并举例说明。     

薄膜阻尼结构的处理位置优化

本文介绍薄膜阻尼结构在使用时，如何选取处理位置才能达到预期的效果．     

S9000DCS系统功能扩充及其软件开发

对美国ＨＯＮＥＹＷＥＬＬ公司Ｓ９０００ＤＣＳ系统软件和系统数据进行了结构分析，着重研究并总结出Ｓ９０００历史数据库的数据结构，开发出ＴＳＲ型实用软件，实现了Ｓ９０００汉化报表生成，同时也拓宽了Ｓ９０００在工业生产中的实际应用范围。     

文化价值观与宋元数学─—数学文化史研究的一个案例

本文运用数学文化史的研究方法，论述了中国古代数学在文化系统中的价值取向．同时本文从中国古代数学在十三世纪下半叶价值观念发生变动的角度，对宋元数学的兴衰提出了新的看法．     

l_p（0＜p≤1）上有界线性算子的表示

放大ｌｐ到空ｌ∞，Ｃ０，Ｃ及ｌｐ中的有界线性算子的表示定理（０＜ｐ≤１）